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The discovery of microRNAs (miRNAs), which are ~22 nucleotide RNAs that inhibit protein synthesis in a sequence-specific manner and are present in a range of species, has born hope of new therapeutic strategies. miRNAs play important roles in development
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING (Summary in Swedish) Ett självmordsförsök innebär ett stort lidande, såväl ho's personen i fråga som ho's omgivningen. Psykiatrin's huvudsakliga syfte i behandlingen av självmordsnära individer är att förhindra upprepade självmordsförsök och självmord. Av dem som gör ett självmordsförsök har 35 – 50% gjort ett eller flera självmordsföAbstract One important task for the mental health services is to prevent suicidal behaviour, especially among persons at high risk, e.g. those who have attempted suicide. In two follow-up samples, one and three months after a suicide attempts, both n=97, we found that 32% and 38% of the patients respectively had no treatment and 30% in each sample had suicidal thoughts. In a randomised controlled
A new passive subharmonic mixer topology is presented and compared to a previously published passive topology. The comparison is conducted using simulations at 30 GHz with a 90-nm CMOS design kit. The advantage of the new passive subharmonic mixer is that it only requires a differential local oscillator (LO) signal, compared to the previously published mixer that requires a quadrature LO signal. T
Objective: To study the association between sexual orientation and self-rated health, including trust, offence, threat of violence, and violence. Design/setting/participants/measurement: The 2008 Public Health Survey in Skåne is a cross-sectional postal questionnaire study. A total of 28,198 persons aged 18-80 years responded (55%). Logistic regressions analysed the association between sexual orie
Associations are not random. Semantic memory is structured in a way that when hearing a category name a listener will automatically think of exemplars belonging to this category. The order in which exemplars come to mind and the frequency of retrieval of exemplars across individuals are measures of category-exemplar associative strength. Associative strength affects a broad range of psychological
AIM: The aim of this retrospective nationwide study was to investigate indications and surgical outcome after pulmonary metastasectomy (PM) in a well-defined cohort of patients and to calculate the proportion of cancer patients who were operated on.METHODS: Between 1984 and 2008, 81 patients (age 54.8 years, 50.6% men) underwent 100 PMs with curative intent in Iceland. For all patients, informatio
Background: Central nervous system (CNS) involvement is associated with relapse in childhood acute lymphoblastic leukemia (ALL) and is a diagnostic challenge. Procedure: In a Nordic/Baltic prospective study, we assessed centralized flow cytometry (FCM) of locally fixed cerebrospinal fluid (CSF) samples versus local conventional cytospin-based cytology (CC) for detecting leukemic cells and evaluati
A decision is the result of comparing one or more alternatives with respect to one or more criteria that we consider relevant to the decision. Decision making can be considered as one of the most important challenges that analysts and experts encounter to solve complex problems. In recent decades, different methods and algorithms have been presented to support decision making. Multi-criteria analy
Objective: To evaluate a simple working procedure for recording postoperative complications. Design: Prospective cohort study. Setting: Teaching hospital, Denmark. Subjects: 218 of 312 patients who were operated on from March to July 1996. Interventions: Follow up 30 days after operation by looking up the local register of complications, review of medical records and by structured telephone interv
The trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of relThe trajectories of politically activist and socially committed interpretations of Islam in (late)modern societies continue to spur heated debate and academic discussion. A recurrent theme is the compatibility of Islamic ideological/legal foundations vis-à-vis secular state institutions and liberal democracy. Other debates concern rights and identity politics, problematizing the recognition of rel
The synchronous firefly genus Pteroptyx Olivier is reassessed from morphological, molecular, and habitat perspectives in Malaysia, and includes some reliably associated females described from morphological features and internal female reproductive anatomy. Phylogenetic analyses using combined morphological and molecular data (where available) for 158 taxa supported all the major features of the ex
BACKGROUND: The possible excess of congenital malformations in infants born after in vitro fertilization (IVF) has been much discussed in the literature, with controversial conclusions. This population based study is aimed at analyzing the presence of congenital malformations in a large group of infants born after IVF and to compare malformation risk both with that of all infants born and accordin
Context: End-stage kidney disease (ESKD) is characterized by high physical and psychological burden, and therefore, more knowledge about the palliative care provided close to death is needed. Objectives: To describe symptom prevalence, relief, and management during the last week of life, as well as end-of-life communication, in patients with ESKD. Methods: This study was based on data from the Swe
The objectives were to evaluate possible associations between the SLC30A8 R325W polymorphism and gestational diabetes mellitus (GDM) as well as postpartum development of type 2 diabetes. Furthermore, we wanted to confirm the prevalence of zinc transporter 8 autoantibodies (ZnT8A), as previously reported, in a larger population and study its predictive value in relation to other β cell specific aut
BACKGROUND: Inversions involving intron 22 (Inv22) of F8 are detected in approximately 45% of all severe hemophilia A patients. Diagnosis is complicated by the large size of the ~9.5 kb int22h repeated sequence which generates the inversions. Methods such as long-range PCR and inverse-shifting PCR are currently used diagnostically, but suffer from low PCR efficiencies and are difficult to standard
BACKGROUND In the lamination process the use of surface treatment is necessary to improve the adhesion between the different layers of the packaging material. Surface treatment can be described as Techniques which change the surface characters without affecting properties of the bulk materials. One of the surface treatments is the ozone treatment where the ozone is applied to the hot melt just be
När Lissabonfördraget trädde i kraft den 1 december 2009 medförde det viktiga förändringar inom EU:s utrikespolitik. Målet var att öka EU:s samstämmighet i dess externa relationer i syfte att stärka EU:s roll som global aktör. Det nya fördraget inrättade en hög representant för den gemensamma utrikes-och säkerhetspolitiken (HR) samt en assisterande utrikestjänst (EEAS). De nya funktionerna är histThe entry into force of the Lisbon Treaty in December 2009 brought several important changes in the field of EU Foreign Policy. The goal was to enhance coherence in EU external relations to strengthen the role of the EU as a global actor. The creations of the High Representative (HR) of the Union on Foreign Affairs and Security Policy and the assisting European External Action Service (EEAS) are t
