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Deficiency in C1 inhibitor (C1INH, SERPING1) is canonically associated with hereditary angioedema (HAE-C1INH) but not thrombosis. To determine the thrombosis risk conferred by loss of C1INH in the general population, we studied genetically-defined C1INH deficiency across 635,823 participants. Functionally deleterious germline coding variation in SERPING1 was rare (~1:10,000), indicating strong gen

Confidentiality in arbitration has for many years been taken for granted by the parties involved. The question has, until recently, almost never been debated. Even though there has been an assumption that there is a duty of confidentiality, it normally does not rest on a statutory basis. Two opposing views have been taken among judges and scholars regarding the legislative silence. One point of vi

Today, 14 years have gone since the whole world turned their backs on Rwanda, the small country in East Africa, during a time when its population needed us the most. These were the same nations that already after the Second World War had made a promise about ''Never Again'', then meaning that they would never again allow another attempt to exterminate an entire ethnic group. It was

When initiating the research for my graduate paper I had a rather straightforward intent in mind. It was to determine if the research being conducted in the bio-health related field was negatively affected by the patent system. If the research was delayed by the patent system I wanted to apprehend why. I came to the conclusion that over the years the sphere where the exchange of intellectual prope

This thesis is conducted in collaboration with Alfa Laval Lund AB. Alfa Laval is a world leading producer of heat transfer, separation and fluid handling equipment. The products help Alfa Laval’s customers to heat, cool, separate and transfer products such as oil, water, chemicals, beverages, starch and pharmaceuticals in over 100 countries all over the world. The hardening competition together wi

Denna uppsats fokuserar på offentliga upphandlingar och behandlar begreppet onormalt låga anbud. Dessa anbudens låga nivå kan vara grundade i dolda motiv eller missförstånd från anbudsgivaren. Detta medför att den upphandlande myndigheten kan vilja förkasta det aktuella anbudet. Den låga nivån kan däremot lika gärna vara helt legitimt och bör därmed inte förkastas. Regelverket samt praxis på områdThis thesis focuses on public procurements and deals with the concept of abnormally low tenders. The low levels in a tender can be founded in a hidden agenda or in a misunderstanding by the tenderer. This means that the contracting authority may wish to reject the current offer. The low level, on the other hand, can just as easily be completely legitimate and should therefore not be discouraged. T

The objectives of treatment in rheumatoid arthritis (RA) are to reduce temporary symptoms due to inflammatory activity and, more importantly, to preserve function. The introduction of potent disease-modifying anti-rheumatic drugs (DMARDs) in recent years has increased the opportunities for effective treatment. However, these treatments come at a substantially higher cost than traditional DMARDs an

In conventional synthetic transmit aperture imaging (STA) the image is built up from a number of low resolution images each originating from consecutive single element firings to yield a high resolution image. This lowers the frame rate and may result in motion artifacts. This paper, describes a method in which all transmitting centers can be excited at the same time and separated at the receiver

Aims/hypothesis Recent genome-wide association studies performed in selected patients and control participants have provided strong support for several new type 2 diabetes susceptibility loci. To get a better estimation of the true risk conferred by these novel loci, we tested a completely unselected population of type 2 diabetes patients from a Norwegian health survey (the HUNT study). Methods We

Low molecular weight protein tyrosine phosphatase (LMW-PTP) dimerizes in the phosphate-bound state in solution with a dissociation constant of K-d = 1.5(+/-0.1) mM and an off-rate on the order of 10(4) s(-1).H-1 and N-15 NMR chemical shifts identify the dimer interface, which is in excellent agreement with that observed in the crystal structure of the dimeric S19A mutant. Two tyrosine residues of

Objective. While the prevalence of radiographic thumb carpometacarpal (CMC1) osteoarthritis (OA) is well-described, little is known about clinically symptomatic disease presenting to physicians for care. We sought to determine the prevalence of doctor-diagnosed CMC1 OA. Methods. Using health care data from Skane in southern Sweden (population 1.24 million), we identified all adults ages >= 20 year

Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55

The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls

Popular Abstract in Swedish Bakgrund Streptococcus pyogenes, eller grupp A streptokocker, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De orsakar ofta relativt harmlösa och lättbehandlade ytliga infektioner i hals (halsfluss) och hud (svinkoppor) men kan också ge djupare och livshotande infektioner. Dessutom förekommer följdsjukdomar efter infektioner med grupp A streptoPathogenic bacteria often produce potent proteases capable of destroying host tissue thereby providing the bacteria with tools for spreading and nutrient access. This thesis describes how group A, C and G streptococci can acquire surface bound protease activity through an alternative mechanism, namely by binding and activation of the human protease precursor plasminogen. Group A streptococci of c

My article deals with the work of the St Joseph Sisters in the Nordic countries, particularly in Denmark and Sweden, from the sisters’ arrival in 1856 to the 1920:ies. These Catholic sisters belonged to a French congregation called "La Congregation des Sœurs de Saint-Joseph de Chambéry", which was founded at the beginning of the nineteenth century and whose motherhouse was in Chambéry in Savoy. Th

Popular Abstract in English Bracings are structural components that assure the stability of the load bearing structures is maintained so as a desired level of load-carrying capacity of them is achieved. The present study as a whole involves investigations of either the temporary or permanent bracings that are often required during the construction phase of steel bridges. Current knowledge concerniA number of steel bridges have suffered lateral-torsional failure during their construction due to their lacking adequate lateral and/or rotational stiffness. In most cases, slight bracing can be of great benefit to the main girders involved through their controlling out-of-plane deformations and enabling the resistance that is needed to be achieved. The present research concerned the performance

OBJECTIVES: To describe the outcome of growth-restricted fetuses with absent or reversed end-diastolic flow (ARED) in the umbilical artery delivered on fetal indication before 30 gestational weeks.METHODS: Between 1998 and 2004, 42 fetuses with intrauterine growth restriction (IUGR) and ARED in the umbilical artery were delivered liveborn by Cesarean section on fetal indication before 30 gestation

This paper assesses the potential changes in the demand for forest-based biomass for various energy purposes in Sweden in 2030 and 2050, respectively. The assessment is based on a review of scenarios and predictions of how the Swedish energy system may develop, taking into account techno-economical conditions. It includes potential changes in district heating, electricity production in combined he

Accurate and internationally comparable human papillomavirus (HPV) DNA genotyping is essential for HPV vaccine research and for HPV surveillance. The HPV Laboratory Network (LabNet) has designed international proficiency studies that can be issued regularly and in a reproducible manner. The 2011 HPV genotyping proficiency panel contained 43 coded samples composed of purified plasmids of 16 HPV typ

We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a Subgroup of n = 20/20 patients with GPi-DBS and n = 45/49