Search results

Low molecular weight protein tyrosine phosphatase (LMW-PTP) dimerizes in the phosphate-bound state in solution with a dissociation constant of K-d = 1.5(+/-0.1) mM and an off-rate on the order of 10(4) s(-1).H-1 and N-15 NMR chemical shifts identify the dimer interface, which is in excellent agreement with that observed in the crystal structure of the dimeric S19A mutant. Two tyrosine residues of

Objective. While the prevalence of radiographic thumb carpometacarpal (CMC1) osteoarthritis (OA) is well-described, little is known about clinically symptomatic disease presenting to physicians for care. We sought to determine the prevalence of doctor-diagnosed CMC1 OA. Methods. Using health care data from Skane in southern Sweden (population 1.24 million), we identified all adults ages >= 20 year

Agricultural intensification has contributed substantially to the increase in food production, but has come at the expense of soil degradation and environmental problems. Management of soil based ecosystem services need to be considered in agricultural management since intensive management implies not only costs to the farmer but also to society. In this study we used data from four long-term (55

The splice variant INS-IGF2 entails the preproinsulin signal peptide, the insulin B-chain, eight amino acids of the C-peptide and 138 unique amino acids from an ORF in the IGF2 gene. The aim was to determine whether levels of specific INS-IGF2 autoantibodies (INS-IGF2A) were related to age at diagnosis, islet autoantibodies, HLA-DQ, or both, in newly diagnosed type 1 diabetes patients and controls

Popular Abstract in Swedish Bakgrund Streptococcus pyogenes, eller grupp A streptokocker, är en av de vanligaste sjukdomsframkallande bakterierna hos människan. De orsakar ofta relativt harmlösa och lättbehandlade ytliga infektioner i hals (halsfluss) och hud (svinkoppor) men kan också ge djupare och livshotande infektioner. Dessutom förekommer följdsjukdomar efter infektioner med grupp A streptoPathogenic bacteria often produce potent proteases capable of destroying host tissue thereby providing the bacteria with tools for spreading and nutrient access. This thesis describes how group A, C and G streptococci can acquire surface bound protease activity through an alternative mechanism, namely by binding and activation of the human protease precursor plasminogen. Group A streptococci of c

My article deals with the work of the St Joseph Sisters in the Nordic countries, particularly in Denmark and Sweden, from the sisters’ arrival in 1856 to the 1920:ies. These Catholic sisters belonged to a French congregation called "La Congregation des Sœurs de Saint-Joseph de Chambéry", which was founded at the beginning of the nineteenth century and whose motherhouse was in Chambéry in Savoy. Th

Popular Abstract in English Bracings are structural components that assure the stability of the load bearing structures is maintained so as a desired level of load-carrying capacity of them is achieved. The present study as a whole involves investigations of either the temporary or permanent bracings that are often required during the construction phase of steel bridges. Current knowledge concerniA number of steel bridges have suffered lateral-torsional failure during their construction due to their lacking adequate lateral and/or rotational stiffness. In most cases, slight bracing can be of great benefit to the main girders involved through their controlling out-of-plane deformations and enabling the resistance that is needed to be achieved. The present research concerned the performance

OBJECTIVES: To describe the outcome of growth-restricted fetuses with absent or reversed end-diastolic flow (ARED) in the umbilical artery delivered on fetal indication before 30 gestational weeks.METHODS: Between 1998 and 2004, 42 fetuses with intrauterine growth restriction (IUGR) and ARED in the umbilical artery were delivered liveborn by Cesarean section on fetal indication before 30 gestation

This paper assesses the potential changes in the demand for forest-based biomass for various energy purposes in Sweden in 2030 and 2050, respectively. The assessment is based on a review of scenarios and predictions of how the Swedish energy system may develop, taking into account techno-economical conditions. It includes potential changes in district heating, electricity production in combined he

Accurate and internationally comparable human papillomavirus (HPV) DNA genotyping is essential for HPV vaccine research and for HPV surveillance. The HPV Laboratory Network (LabNet) has designed international proficiency studies that can be issued regularly and in a reproducible manner. The 2011 HPV genotyping proficiency panel contained 43 coded samples composed of purified plasmids of 16 HPV typ

We assessed the effects of deep brain stimulation of the subthalamic nucleus (STN-DBS) or internal pallidum (GPi-DBS) on health-related quality of life (HrQoL) in patients with advanced Parkinson's disease participating in a previously reported multicenter trial. Sickness Impact Profile (SIP) questionnaires were available for analysis in a Subgroup of n = 20/20 patients with GPi-DBS and n = 45/49

Osteoporosis is a major health problem affecting more than 75 million people throughout Europe, USA and Japan. Epidemiological studies have determined that both genetic and environmental factors contribute to the pathogenesis of osteoporosis. We have investigated the association between polymorphisms at the osteocalcin locus and variables linked to bone health. Osteocalcin provides a link between

Intracortical neural probes have in the last couple of years been developed from stiff single probes to stiff multi-electrode neural probes to flexible multi-electrode neural probes. One reason for the change in design is that more than one recording/stimulation electrode, as in the case with a single wire, is needed for more advanced studies. The stiff multi-electrode probes were fabricated using

Identification and relative quantification of hundreds to thousands of proteins within complex biological samples have become realistic with the emergence of stable isotope labeling in combination with high throughput mass spectrometry. However, all current chemical approaches target a single amino acid functionality (most often lysine or cysteine) despite the fact that addressing two or more amin

Introduction: Few large studies have examined the heritability of venous thromboembolism (VTE). Moreover, twin studies have been suggested to overestimate heritability. The aim of the present study was to determine the heritability nationwide in the general Swedish population using full siblings and half-siblings. Methods: VTE was defined using the Swedish patient register. Full sibling (FS) and h

Provupparbetning är ett viktigt steg i många metoder för kemisk analys.Detta gäller framförallt fasta prover då de kemiska ämnena som avses för analys, även kallade analyter, måste extraheras ut. Det vill säga att genomföra en överföring av analyter från provet till ett lösningsmedel. Därefter kan halten bestämmas med de metoder som ofta finns till hands i ett analyslaboratorium. I de fall då fettSupercritical fluid extraction is an extraction technique suitable for lipophilic compounds from solid samples. Most commonly supercritical carbon dioxide is the main component in the extraction phase, rendering the technique relatively environmentally benign. The extraction technique is rapid due to the low viscosity and the high diffusivity of analytes in the supercritical extraction phase.The s

Immune checkpoint inhibitors (ICPI), such as ipilimumab [anti-cytotoxic T-lymphocyte antigen-4 (CTLA-4) antibody] and nivolumab or pembrolizumab [anti-programmed cell death protein-1 (PD-1) antibodies], improve survival in several cancer types. Since inhibition of CTLA-4 or PD-1 leads to non-selective activation of the immune system, immune-related adverse events (irAEs) are frequent. Enterocoliti

Hereditary nonpolyposis colorectal cancer (HNPCC) is caused by a germline mutation in one of several DNA repair genes, which in the tumors is reflected as microsatellite instability (MSI). MSI+ tumors have been found to carry somatic frameshift mutations in mononucleotide repeats within the coding regions of several genes involved in growth control, apoptosis, and DNA repair, e.g., TGFBRII, BAX, I

Most of the common modeling approaches to premixed combustion in engineering applications are either based on the assumption of infinitely fast chemistry or the flamelet assumption with simple chemistry. The level-set flamelet library approach (FLA) has shown great potential in predicting major species and heat release, as well as intermediate and minor species, where more simple models often fail

Popular Abstract in Swedish Alla ryggradsdjur har ögon av en typ som kallas kameraöga. Som man kan höra på namnet så fungerar ett sådant öga ungefär som en kamera. En lins fokuserar ljuset på ett ljuskänsligt lager som i ett öga kallas för näthinna (retina). De ljuskänsliga cellerna i näthinnan heter tappar och stavar. Stavarna används för seende i mörker och tapparna används för seende i starkareMany fishes have well-developed visual systems with color vision capabilities. The crystalline lens is the major refractive element in a fish eye since the cornea is optically inactive underwater. A typical fish eye has a large pupil and a lens of short focal length, features that increase light gathering ability. They lead also to short depth of focus, which makes the eye particularly susceptible