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Limitations in the Use of Unipolar Charging for Electrical Mobility Sizing Instruments: A Study of the Fast Mobility Particle Sizer

A comparison between three different types of particle sizing instruments (fast mobility particle sizer, FMPS; electrical low pressure impactor, ELPI; and scanning mobility particle sizer, SMPS) and one condensation particle counter (CPC) was made to compare instrument response in terms of size distributions and number concentration. Spherical oil droplets in 39 different sizes, with geometric mea

Intraspecific variations of Dekkera/Brettanomyces bruxellensis genome studied by capillary electrophoresis separation of the intron splice site profiles

In enology, "Brett" character refers to the wine spoilage caused by the yeast Dekkera/Brettanomyces bruxellensis and its production of volatile phenolic off-flavours. However, the spoilage potential of this yeast is strain-dependent. Therefore, a rapid and reliable recognition at the strain level is a key point to avoid serious economic losses. The present work provides an operative tool to assess

Individualizing the Use of Negative Pressure Wound Therapy for Optimal Wound Healing: A Focused Review of the Literature

Currently available research suggests that negative pressure wound therapy (NPWT) creates a moist wound healing environment, drains exudate, reduces tissue edema, contracts the wound edges, mechanically stimulates the wound bed, and influences blood perfusion at the wound edge, which may lead to angiogenesis and the formation of granulation tissue. Although no clear evidence is available that NPWT

The MreB-like protein Mbl of S. coelicolor A3(2) depends on MreB for proper localization and contributes to spore wall synthesis.

Most bacteria with a rod-shape morphology contain an actin-like cytoskeleton consisting of MreB polymers which form helical spirals underneath the cytoplasmic membrane to direct peptidoglycan synthesis for elongation of the cell wall. In contrast MreB of Streptomyces coelicolor is not required for vegetative growth, but has a role in sporulation. Beside MreB, S. coelicolor encodes two further MreB

DNA building blocks: keeping control of manufacture

Ribonucleotide reductase (RNR) is the only source for de novo production of the four deoxyribonucleoside triphosphate (dNTP) building blocks needed for DNA synthesis and repair. It is crucial that these dNTP pools are carefully balanced, since mutation rates increase when dNTP levels are either unbalanced or elevated. RNR is the major player in this homeostasis, and with its four different substra

Direct and indirect impacts of climate and socio-economic change in Europe : a sensitivity analysis for key land- and water-based sectors

Integrated cross-sectoral impact assessments facilitate a comprehensive understanding of interdependencies and potential synergies, conflicts, and trade-offs between sectors under changing conditions. This paper presents a sensitivity analysis of a European integrated assessment model, the CLIMSAVE integrated assessment platform (IAP). The IAP incorporates important cross-sectoral linkages between

Experiences of micturition problems, indwelling catheter treatment and sexual life consequences in men with prostate cancer

Men with prostate cancer (n=25) were interviewed, focusing on experiences of micturition problems, indwelling catheter treatment and sexual life consequences. Narrations were found to be practical and technical descriptions rather than emotional, and experiences were described with reduction and negligence regarding personal well-being and the impact of problems. Phenomenological-hermeneutic analy

Integration of Molecular Biology and Morphology in Effusions with Focus on in situ Detection of Telomerase and its Components

Popular Abstract in Swedish Den viktigaste uppgiften inom den kliniska cytologin är att påvisa cancerceller i olika typer av cellprover. Många olika cancertumörer sprider sig till lungsäcken och bukhålan och ger då ofta upphov till vätska (exsudat) som innehåller cancerceller. Ofta kan cancerdiagnosen ställas på grundval av cellernas utseende men detta är inte alltid möjligt, eftersom cancercellerClinical cytology is a rapid method to detect malignancy in effusions of the serous cavities, but the morphological characteristics of the cells do not always allow diagnosis and a specific marker for malignant cells would improve the diagnostic performance. Telomerase adds telomere repeats to the chromosome ends. It is the most promising universal indicator of malignancy and the project focuses o

Three-Dimensional Metal-Semiconductor Heterostructures for Device Applications

Fabrication and characterisation of buried metal contacts in compound semiconductors are demonstrated. The contacts have been investigated due to their usage both as gates in transistors and as active or passive elements in novel devices. A detailed description of the processing conditions for fabrication of nm-sized W-structures in a lift-off process is given. These structures have been embedded

An economic evaluation of combination treatment with budesonide and formoterol in patients with mild-to- moderate persistent asthma

Patients with mild asthma may benefit from increasing their inhaled corticosteroid dose, adding a tong-acting beta(2)-agonist, or both. This study assessed the cost-effectiveness of these options. Patients aged greater than or equal to12 years with mild-to-moderate persistent asthma (n = 1272) were randomised to twice-daily, double-blind treatment with budesonide 100 mug, budesonide 100 mug plus f

Brick makers, builders and commissioners as agents in the diffusion of Hellenistic fired bricks : choosing social models to fit archaeological data

The aim of this study is to understand the mechanisms behind the diffusion of fired bricks in Hellenistic Europe, initiated in the north Aegean in the 4th century BC. To this end, a social diffusion model is used to simulate the available archaeological data pertaining to this process. The starting point in the construction of the model is the assumption that different categories of people contrib

Swedish experience-based value sets for EQ-5D health states

PurposeTo estimate Swedish experience-based value sets for EQ-5D health states using general population health survey data.MethodsApproximately 45,000 individuals valued their current health status by means of time trade off (TTO) and visual analogue scale (VAS) methods and answered the EQ-5D questionnaire, making it possible to model the association between the experience-based TTO and VAS values

Syntes och design : Den intellektuelle politikern som konstnär

Popular Abstract in Swedish Hur löser den intellektuelle politikern problem och hur skapas kontakten med den politiska omgivningen? Svaren på frågorna skall kortfattat presenteras och är intressanta för politiker, partier, väljare och forskare. Svaren visar nämligen hur intellektuella politiker under kristider producerar och presenterar innovativa lösningar som kan få stor betydelse för samhällsutA new theory on the intellectual politician, which has the ability to produce a designed type of problem-solving, has been developed from political science theory, cognitive theory as well as art theory. A cognitive concept, modified integrative complexity, consisting of four sub-concepts, frame reflection, differentiation, reframing and integration has been developed. The relation between politic

The combination of clofarabine, etoposide, and cyclophosphamide shows limited efficacy as a bridge to transplant for children with refractory acute leukemia : results of a monitored prospective study

Clofarabine has been shown to effectively induce remission in children with refractory leukemia. We conducted a prospective trial (clinicval.trials.gov NCT01025778) to explore the use of clofarabine-based chemotherapy as a bridge-to-transplant approach. Children with refractory acute leukemia were enrolled to receive two induction courses of clofarabine, etoposide, and cyclophosphamide (CloEC). Re

Evaluation of a Novel Capacitor Charging Structure for Flicker Mitigation in High-Power Long-Pulse Modulators

In order to generate high-voltage high-pulsed power, klystron modulators necessarily contain at least one capacitor bank charging structure supplying the energy to be released during the pulse. Conventional charging structures are based on ac/dc front-end units typically based on diode rectifiers combined with power charging structures operated in on/off mode as a second stage, producing prohibiti

From space to specs : Requirements for 4MOST

4MOST,1 the 4m Multi-Object spectrographic Survey Telescope, is an upcoming optical, fiber-fed, MOS facility for the VISTA telescope at ESO's Cero Paranal Observatory (Chile). The preliminary design of 4MOST features 2,400 fibers split into a low-resolution (1,600 fibers, 390-900 nm, R > 5; 000) and a high-resolution channel (800 fibers, three arms, ∼20-25 nm coverage each, R > 18; 000) with an Ec

Evaluating the safety benefit of retrofitting motorways section with barriers meeting a new EU standard : Comparison of observational before–after methodologies

The road safety barriers are today designed and installed in compliance with the European standards for Road Restraint Systems (EN 1317), which lays down common requirements for the testing and certification in all EU countries. The introduction of the European Union (EU) regulation for safety barriers, which is based on performance, has encouraged European road agencies to perform an upgrade of t

How Standards and Modularity can improve Humanitarian Supply Chain Responsiveness: The Case of Emergency Response Units

Purpose – The purpose of this paper is to increase understanding of the use of standards and modularity for improving responsiveness in the humanitarian context. Design/methodology/approach – Based on a conceptual framework and a systematic literature review, the authors conducted a longitudinal, explorative case on the Emergency Response Unit (ERU) concept in the International Federation of Red C

Cutting through the noise : A narrative review of Alzheimer's disease plasma biomarkers for routine clinical use

As novel, anti-amyloid therapies have become more widely available, access to timely and accurate diagnosis has become integral to ensuring optimal treatment of patients with early-stage Alzheimer's disease (AD). Plasma biomarkers are a promising tool for identifying AD pathology; however, several technical and clinical factors need to be considered prior to their implementation in routine clinica

Best ear hearing level, time factors and language outcome in Swedish children with mild and moderate hearing loss with hearing aids

Aim: The risk for language disorder is high in children with all levels of hearing loss (HL). Early identification and intervention should be as important for children with mild HL as for those with more severe HL. Despite new-born hearing screening, a recent survey of speech language therapist services in southern Sweden indicates that children with mild and moderate HL are severely neglected whe