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Background: The aggressive nature of breast cancers detected between planned mammographic screens, so-called interval cancers, remains elusive. Here, we aim to characterise underlying molecular features of interval cancer. Methods: From 672 patients with invasive breast cancer, we analysed gene expression differences between 90 ‘true’ interval cancer cases (i.e. women with low-dense breasts define
Semi-arid and arid ecosystems are important for the global C cycle. Despite this, it remains unclear how organic matter fractions vary across latitudinal gradients, and what drives this variation, in dry ecosystems. In this study, we sampled soils from 100 sites across a latitudinal gradient in the dry valleys of southwestern China to explore the latitudinal patterns of light fraction organic matt
The European Union's Natura 2000 (N2000) is among the largest international networks of protected areas. One of its aims is to secure the status of a predetermined set of (targeted) bird and butterfly species. However, nontarget species may also benefit from N2000. We evaluated how the terrestrial component of this network affects the abundance of nontargeted, more common bird and butterfly specie
OBJECTIVE: To assess pulmonary function and Chronic Obstructive Pulmonary Disease (COPD) development over time in patients with primary Sjögren's Syndrome (pSS) and the association between pulmonary function, radiographic findings, respiratory symptoms and clinical features of pSS, taking cigarette consumption into account.METHODS: Forty patients with pSS (mean age 66 yrs, range 42-81 yrs, 39 wome
Multicenter clinical and quantitative magnetic resonance imaging (qMRI) studies require a high degree of reproducibility across different sites and scanner manufacturers, as well as time points. We therefore implemented a multiparameter mapping (MPM) protocol based on vendor's product sequences and demonstrate its repeatability and reproducibility for whole‐brain coverage. Within ~20 min, four MPM
This study follows groups in Sweden that are involved in a political struggle to change norms regarding sexuality and disability. The groups are mostly connected to the disability movement or the movement of sexual politics. The following questions have guided the research process: How do the groups describe their activities? What strategies do they use? What relations can be identified between th
SeeMe is a pedestrian crosswalk warning system with automatic pedestrian detection that is mounted on crosswalk signs. Amber flashing lights are activated when pedestrians are approaching or crossing the crosswalk. The aim is to attract motorists’ attention, to improve yielding behavior and to reduce conflicts. A before-after study with a matched comparison group has been conducted in the Norwegia
Context. The Gaia-ESO Public Spectroscopic Survey using FLAMES at the VLT has obtained high-resolution UVES spectra for a large number of giant stars, allowing a determination of the abundances of the key chemical elements carbon and nitrogen at their surface. The surface abundances of these chemical species are known to change in stars during their evolution on the red giant branch (RGB) after th
Relocating Beijing's manufacturing industry, a key measure in the strategy for decentralizing Beijing's non-capital functions, may inadvertently increase environmental pressures in the receiving cities. This study develops a quantitative method to comprehensively identify the environmental effects caused by regional industrial relocations. First, a set of relocated industries is selected by consid
Primary HPV screening for cervical cancer by HPV mRNA testing (Aptima)was implemented in January 2017, for women ≥30 through 70 years, in the Region of Skåne, Sweden. HPV positive samples underwent cytology assessment, and women with any degree of abnormal cytology were referred for colposcopy. The aim was to audit the primary HPV screening program, by comparing the cytology results to those of co
Geocoding longitudinal and individual-level historical demographic databases enables novel analyses of how micro-level geographic factors affected demographic outcomes over long periods. However, such detailed geocoding involves high costs. Additionally, the high spatial resolution cannot be properly utilized if inappropriate methods are used to quantify the geographic factors. We assess how diffe
AIMS: Lumbar disc prolapse is a frequent indication for surgery. The few available long-term follow-up studies focus mainly on repeated surgery for recurrent disease. The aim of this study was to analyze all reasons for additional surgery for patients operated on for a primary lumbar disc prolapse. METHODS: We retrieved data from the Swedish spine register about 3,291 patients who underwent primar
Background: Short-term trials conducted in adults with type 2 diabetes mellitus (T2DM) showed that reducing sedentary behaviour by performing regular short bouts of light-intensity physical activity enhances health. Moreover, support for reducing sedentary behaviour may be provided at a low cost via mobile health technology (mHealth). There are a wide range of mHealth solutions available including
Understanding the inherited nature of how biological processes dynamically change over time and exhibit intra- and inter-individual variability, due to the different responses to environmental stimuli and when interacting with other processes, has been a major focus of systems biology. The rise of single-cell fluorescent microscopy has enabled the study of those phenomena. The analysis of single-c
There is a long history of avian studies investigating the impacts of urbanization. While differences in several life-history traits have been documented, either between urban and rural populations or across generalized urbanization gradients, a detailed understanding of which specific environmental variables cause these phenotypic differences is still lacking. Here, we quantified several local en
Shelterbelts (or windbreaks) can effectively improve the microclimate and soil conditions of adjacent farmland and thus increase crop yield. However, the individual contribution of these two factors to yield changes is still unclear since the short-term effect from the microclimate and the accumulated effect from the soil jointly affect crop yield. The latter (soil effect) is supposed to remain af
Investments in Enterprise Systems (ES) represent a significant part of many organisations’ investments. Time and budget overruns have been more a rule than an exception in ES implementations. One critical success factor for improving ES implementation is Enterprise Systems Implementation Methodologies (ESIMs). There is a lack of research on the use of ESIMs; however, the scant research does show c
e concept of ecosystem services was originally developed to illustrate the benefits that natural ecosystems generate for society and to raise awareness for biodiversity and ecosystem conservation. In this article we identify major challenges and opportunities for ecologists involved in empirical or modeling ecosystem service research. The first challenge arises from the fact that the ecosystem ser
Health status and functional profile at admission of nursing home residents in Iceland over 11-year period. International Journal of Older People Nursing doi: 10.1111/j.1748-3743.2011.00287.x Background. The knowledge over time of the health status and changes in care needs of newly admitted nursing home residents is limited. Objectives. To investigate trends in residents' health status and func
Detailed weather predictions are of interest e.g. to protect humans and society from damages caused by extreme weather. To do this today’s forecast models need higher resolution, i.e. less distance between measure points. So-called non-hydrostatic models are used when this distance decreases. The development of this type of models has progressed during the past 20 years due to more powerful comput
