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Osteoblasts, osteocytes, and osteoclasts (OCs) are involved in the bone production and resorption, which are crucial in bone homeostasis. OC hyperactivation plays a role in the exaggerated bone resorption of diseases such as osteoporosis, rheumatoid arthritis, and osteolytic tumor metastases. This work stems from the finding that OCs can express B7h (ICOS-Ligand), which is the ligand of the ICOS T
The world's fisheries have been in decline for more than forty years. In Mexico, about 80% of the fishery resources are at maximum capacity levels or overexploited. Given the magnitude of the problem, there is a need for solutions that involve all actors in the fish supply chain. However, solutions and research on how actors in the middle of the supply chain such as restaurants can be integrat
Considering the growing importance of environmental issues on the international political scene, the question arises as to how these issues are incorporated into the agenda and procedures of international organizations (IOs) and institutions. The World Trade Organization (WTO) - one of the largest IOs – has to handle a strong mandatory connection to global trade as well as an increasing environmen
Given the recent changes in how central banks use the tools they have at hand to control inflation and money supply this study aims to evaluate the effect that interest rate policy has had on IPO underpricing. More specifically, the effect that negative interest rate policies and quantitative easing has had on the size of the underpricing premium. To test these effects, we collected IPO data from
Amidst debates on the potential adverse consequences of high-technology industries on employment, it is imperative to gain a deeper understanding of how high-tech industries shape labour markets outcomes across various socio-economic, institutional, and geographical contexts. This thesis seeks to contribute to this understanding by estimating the impact of high-technology industries on employment
The Chernobyl catastrophe is still referred to as the biggest radioactivity fallout problem in the history of the world. The cloud that was released from the broken reactor travelled across larger parts of the European continent and the after-effects of the radiation are said to be felt and faced throughout the impacted regions up to this day – and that this process is far from over. This thesis
Sweden is perceived to be top ranking. and a 'role model', in terms of its volume of academic R&D. This perception is based on analyses using two standard indicators. We assess the validity of these and argue that institutional features skew the result in favour of a high ranking. Swedish academic R&D is more appropriately characterised as average. or below average. in terms of input and a
A lasting legacy of the International Polar Year (IPY) 2007-2008 was the promotion of the Permafrost Young Researchers Network (PYRN), initially an IPY outreach and education activity by the International Permafrost Association (IPA). With the momentum of IPY, PYRN developed into a thriving network that still connects young permafrost scientists, engineers, and researchers from other disciplines.
Purpose: According to the 2017 St Gallen surrogate definitions of the intrinsic subtypes, Ki67, progesterone receptor (PR) and Nottingham histological grade (NHG) are used for prognostic classification of estrogen receptor (ER) positive/HER2-negative breast cancer into luminal A- or luminal B-like. The aim of the present study was to investigate if additional biomarkers, related to endocrine signa
Bibliometric indicators are increasingly used to fund and evaluate scientific research. Since the number of authors in a paper and the number of has increased it is difficult to determine the individual contribution of authors. Suggested approaches include the study of author position or the corresponding author. Our findings show that the corresponding author is most likely to appear first and th
A significant part of our cultural heritage consists of wood. Research on historical wooden structures and artefacts thereby provides knowledge of people’s daily lives and the society in which they lived. Dendrochronology is a well-established dating method of wood that can also provide valuable knowledge about climate dynamics, environmental changes, silviculture, and cultural transformations. Ho
Streptococcus suis is part of the pig commensal microbiome but strains can also be pathogenic, causing pneumonia and meningitis in pigs as well as zoonotic meningitis. According to genomic analysis, S. suis is divided into asymptomatic carriage, respiratory and systemic strains with distinct genomic signatures. Because the strategies to target pathogenic S. suis are limited, new therapeutic approa
Dendritic cells (DCs) are potent antigen-presenting cells that might play contradictory roles during HIV-1 infection, contributing not only to antiviral immunity but also to viral dissemination and immune evasion. Although DCs are characterized by enormous functional diversity, it has not been analyzed how differentially programmed DCs interact with HIV-1. We have previously described the reprogra
To elucidate the etiology of type 1 diabetes, the affected pancreas needs to be thoroughly characterized. Pancreatic innervation has been suggested to be involved in the pathology of the disease and a reduction of sympathetic innervation of the islets was recently reported. In the present study, we hypothesized that parasympathetic innervation would be altered in the type 1 diabetes pancreas. Huma
The ego depletion effect has been examined by over 300 independent studies during the past two decades. Despite its pervasive influence, recently this effect has been severely challenged and asserted to be a fake. Based on an up-to-date meta-analysis that examined the effectiveness of each frequently used depleting task, we preregistered the current experiment with the aim to examine whether there
