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ObjectiveFoot and ankle problems are common in adults, and large observational studies are needed to advance our understanding of the etiology and impact of these conditions. Valid and reliable measures of foot and ankle symptoms and physical function are necessary for this research. This study examined psychometric properties of the Foot and Ankle Outcome Score (FAOS) subscales (pain, other sympt
The responses of the benthic marine dinoflagellate Prorocentrum lima to nutrient stress induced by unbalanced N:P ratios were the subject of this study. Batch cultures of P. lima cells were grown under NP sufficient (N as nitrate and ammonium) and deficient conditions, and the cell growth and toxicity were followed for eight weeks. P. lima grew slowly in all nutrient conditions and net growth rate
SCF (Skp1/Cul1/F-box) ubiquitin ligases act as master regulators of cellular homeostasis by targeting key proteins for ubiquitylation. Here, we identified a hitherto uncharacterized F-box protein, FBXO28 that controls MYC-dependent transcription by non-proteolytic ubiquitylation. SCFFBXO28 activity and stability are regulated during the cell cycle by CDK1/2-mediated phosphorylation of FBXO28, whic
This article explores how the image of the USA has developed in two major Russian daily newspapers, Izvestiya and Komsomolskaya Pravda, in a time period comprised of a total 20 weeks’ of study in the years of 1984, 1994, 2004 and 2009. For Russia this time span was dramatic: it moved from seemingly stable superpower in the 1980s, over the chaos after the dissolution of the Soviet Union in the 1990
Background We investigated whether prediagnostic reported intake of dairy products and dietary calcium are associated with colorectal cancer (CRC) survival. Methods Data from 3,859 subjects with CRC (42.1% male, mean age at diagnosis 64.2 ± 8.1 years) in the European Investigation into Cancer and Nutrition (EPIC) cohort were analyzed. Intake of dairy products and dietary calcium was assessed at ba
We have examined the geometric and electronic structures of iron phthalocyanine assemblies on a Cu(111) surface at different sub- to mono-layer coverages and the changes induced by thermal annealing at temperatures between 250 and 320 °C by scanning tunneling microscopy, x-ray photoelectron spectroscopy, and x-ray absorption spectroscopy. The symmetry breaking observed in scanning tunneling micros
This chapter is devoted to modeling and optimization techniques applicable to communication network design and planning. The main emphasis is put on the models dealing with optimization of the capacity of network resources and traffic routing that lead to tractable optimization problems. It is a common belief that the right means for such modeling are multicommodity flow networks (MFN). MFN form a
A new kind of linguistic exercise based on concordances samples from BNC was first used experimentally in an English lecture at a Vietnamese university for two groups: one was using concordances, one not. The group using concordances could get more correct answers and devlop activeness in exploring word structures and rules.
The argument of our third lecture showed that iconicity could only be saved from the critical arguments advanced by Bierman and Goodman by means of introducing a properly structured common sense world. In this lecture, we will first consider to what extent the linguistic model may still be helpful, and in which respects it is misleading. Then the necessary furnishing of the common sense world, whi
Neuropeptide Y (NPY) has been shown to be involved in the control of several neuroendocrine functions. Moreover, in animal models, NPY produces behavioral effects that are similar to those induced by anxiolytics. We studied NPY-like immunoreactivity (NPY-LI) in cerebrospinal fluid (CSF) in two primary degenerative dementias, Alzheimer disease (AD, n = 34) and frontotemporal dementia (FTD, n = 22)
Popular Abstract in Swedish IgA-nefropati (IgAN) är den vanligaste formen av primär inflammation av njurarna och Henoch-Schönlein purpura (HSP) den vanligaste formen av kärlinflammation i barndomen. HSP kan också drabba njurarna och kallas då Henoch-Schönlein nefropati (HSN). Orsaken till båda sjukdomar är inte helt klarlagd ännu. Båda kännetecknas av vävnadsinlagringar med immunoglobulin A (IgA)IgA nephropathy (IgAN) is the most common form of primary glomerulonephritis and Henoch-Schönlein purpura (HSP) the most common form of vasculitis in childhood. HSP may affect kidneys, a complication termed Henoch-Schönlein nephropathy (HSN). Renal pathology in HSN resembles that seen in IgAN. The pathogenesis of IgAN and HSP is so far unclear. Both are characterized by tissue deposits of undergly
The objective of the study was to test whether live plants on computer workstations with and without window view had restorative effects. Guided by Stress Recovery Theory and Attention Restoration Theory a mixed randomized experiment was conducted exploring restorative effects of plants, including mediating effects of perceived fascination. Eighty-five participants carried out a 1-hr work session
Alterations in cellular pathways related to both endocrine and vascular endothelial growth factors (VEGF) may contribute to breast cancer progression. Inhibition of the elevated levels of these pathways is associated with clinical benefits. However, molecular mechanisms by which endocrine-related pathways and VEGF signalling cooperatively promote breast cancer progression remain poorly understood.
Few epidemiologic studies have examined the hypothesis that circulating androgens are involved in the development of ovarian cancer. We investigated the association between prediagnostic serum levels of androgens and sex hormone–binding globulin (SHBG) and ovarian cancer risk in a case-control study nested within the European Prospective Investigation into Cancer and Nutrition cohort. One hundred
Based on spectra from F and G dwarf stars, we present elementalabundance trends in the Galactic thin and thick disks in the metallicityregime -0.8< [Fe/H < +0.4. Our findings can besummarized as follows. 1) Both the thin and the thick disks show smoothand distinct abundance trends that, at sub-solar metallicities, areclearly separated. 2) For the alpha -elements the thick disk showssignatures of c
