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After a reperfused myocardial infarction (MI), dynamic tissue changes occur (edema, inflammation, microvascular obstruction, hemorrhage, cardiomyocyte necrosis, and ultimately replacement by fibrosis). The extension and magnitude of these changes contribute to long-term prognosis after MI. Cardiac magnetic resonance (CMR) is the gold-standard technique for noninvasive myocardial tissue characteriz

Several experimental evidences suggested that beta1 integrin-mediated adhesion of hematopoietic stem cells (HSC) is important for their function in the bone marrow (BM). Using induced deletion of the beta1 integrin gene restricted to the hematopoietic system, we show that beta1 integrin is not essential for HSC retention in the BM, hematopoiesis, and trafficking of lymphocytes. However, immunizati

The Gaia-ESO Survey was designed to target all major Galactic components (i.e. bulge, thin and thick discs, halo and clusters), with the goal of constraining the chemical and dynamical evolution of the MilkyWay. This paper presents the methodology and considerations that drive the selection of the targeted, allocated and successfully observed Milky Way field stars. The detailed understanding of th

BACKGROUND: Coronary atherosclerosis detected by imaging is a marker of elevated cardiovascular risk. However, imaging involves large resources and exposure to radiation. The aim was, therefore, to test whether nonimaging data, specifically data that can be self-reported, could be used to identify individuals with moderate to severe coronary atherosclerosis.METHODS AND RESULTS: We used data from t

Granzyme B (GzmB) has previously been shown to be critical for CD8(+) T cell-mediated graft-versus-host disease (GVHD) but dispensable for GVHD mediated by CD4(+) T cells. However, previous studies used high doses of CD4(+) T cells in MHC-mismatched models that caused rapid and lethal GVHD. Because of the hyperacute lethality, it is possible that the role of GzmB was concealed by the system. There

Background: Oral contraceptive use has been associated with an increase in the risk of breast cancer in young women. We examined whether this association is seen in women at high risk of breast cancer because they carry a mutation in one of two breast cancer susceptibility genes, BRCA1 and BRCA2. Methods: We performed a matched case-control study on 1311 pairs of women with known deleterious BRCA1

Previously published data from our group and others demonstrate that human milk oligosaccharide (HMOs), as well as milk and infant fecal microbial profiles, vary by geography. However, little is known about the geographical variation of other milk-borne factors, such as lactose and protein, as well as the associations among these factors and microbial community structures in milk and infant feces.

The adult immune system consists of cells that emerged at various times during ontogeny. We aimed to define the relationship between developmental origin and composition of the adult B cell pool during unperturbed hematopoiesis. Lineage tracing stratified murine adult B cells based on the timing of output, revealing that a substantial portion originated within a restricted neonatal window. In addi

Rationale: Adults may exhibit characteristics of both asthma and chronic obstructive pulmonary disease (COPD), a situation recently described as asthma-COPD overlap (ACO). There is a paucity of information about ACO in primary care. Objectives: To estimate the prevalence and describe characteristics of individuals withACOin primary care practices among patients currently diagnosed with asthma, COP

There is a close relationship between the SARS-CoV-2 virus and lipoproteins, in particular high-density lipoprotein (HDL). The severity of the coronavirus disease 2019 (COVID-19) is inversely correlated with HDL plasma levels. It is known that the SARS-CoV-2 spike (S) protein binds the HDL particle, probably depleting it of lipids and altering HDL function. Based on neutron reflectometry (NR) and

Medicinsk rätt är ett brett rättsområde som behandlar juridiska aspekter på medicinsk verksamhet av olika slag. Historiskt har regleringen av medicinsk verksamhet fokuserat på nationella utmaningar. Krig och kriser har blivit viktiga väckarklockor för internationalisering av medicinsk rätt och skapandet av folkrättsliga regler på området. Behovet att skydda skadade personer under krig, liksom medi

Our understanding of how class-switch recombination (CSR) to IgA occurs in the gut is still incomplete. Earlier studies have indicated that Tregs are important for IgA CSR and these cells were thought to transform into follicular helper T cells (Tfh), responsible for germinal center formation in the Peyer's patches (PP). Following adoptive transfer of T-cell receptor-transgenic (TCR-Tg) CD4 T cell

Objectives This study aims to describe the data structure and harmonisation process, explore data quality and define characteristics, treatment, and outcomes of patients across six federated antineutrophil cytoplasmic antibody-associated vasculitis (AAV) registries. Methods Through creation of the vasculitis-specific Findable, Accessible, Interoperable, Reusable, VASCulitis ontology, we harmonised

Master’s Dissertation Structural Mechanics Report TV SM -5236 FELIC IA N ILSSO N & FILIPPA D A H L D Y N A M IC D ESIG N O F B R ID G ES O N H IG H -SPEED R A ILW A Y LIN ES FELICIA NILSSON & FILIPPA DAHL DYNAMIC DESIGN OF BRIDGES ON HIGH-SPEED RAILWAY LINES Parametric Studies of Slab Bridges and Portal Frame Bridges DEPARTMENT OF CONSTRUCTION SCIENCES DIVISION OF STRUCTURAL MECHANICS ISRN LUTVDG/

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm5000/web5236.pdf - 2026-05-30

Microsoft Word - katrin och satu formated-14pt.doc Some thoughts on Balto-Finnic passives and impersonals KATRIN HIIETAM (INDEPENDENT SCHOLAR) & SATU MANNINEN (LUND UNIVERSITY) Abstract This working paper focuses on the question of whether the Balto-Finnic impersonal construction can be classified as active or passive. We contrast it with the criteria for impersonal active constructions, listed in

https://www.sol.lu.se/fileadmin/media/forskning/workingpapers/engelska/vol05/Hiietam-Manninen-wp05.pdf - 2026-05-30

Microsoft Word - Final-report-WP1-May01-TVSM_3056.doc Structural Mechanics Report TV SM -3056 G U STA FSSO N , P. J., and SERRA N O , E G LU ED -IN R O D S FO R TIM B ER STR U C TU R ES - D evelo p m en t o f a C alcu latio n M o d e PER JOHAN GUSTAFSSON and ERIK SERRANO GLUED-IN RODS FOR TIMBER STRUCTURES Development of a Calculation Model Printed by KFS i Lund AB, Lund, Sweden, December 2002. Fo

https://www.byggmek.lth.se/fileadmin/byggnadsmekanik/publications/tvsm3000/web3056.pdf - 2026-05-31