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Development and Evaluation of Methods in Source Apportionment of the Carbonaceous Aerosol

Atmosfäriska partiklar (aerosoler) finns överallt i jordens atmosfär. Masskoncentrationen av dessa varierar kraftigt beroende på i vilken miljö man mäter. I stadsluft kan man uppmäta tiotals mikrogram per kubikmeter medan man i arktiska områden uppmäter nanogram per kubikmeter. Den kolhaltiga aerosolen utgör en betydande del av atmosfärsaerosolens massa och är känd för att påverka människors och dCarbonaceous aerosols are known to affect human health negatively and to affect the climate of Earth. As specific types of aerosols originate from specific sources, it is important to know the amount of aerosols emitted from each source. Aerosol source apportionment is an important tool in mitigating air pollution and improving air quality. The subject of this thesis was the evaluation and develop

Hand eczema in healthcare workers : a questionnaire survey of risk factors and work-related exposures

Recent data on the prevalence and causes of hand eczema among healthcare workers in Sweden are lacking. Multidrug-resistant bacteria have necessitated improved hand hygiene and preventive measures. This has led to an increase in the use of disposable rubber gloves and hand disinfectants, which might influence the risk of hand eczema. Our aims were to identify healthcare workers with hand eczema; t

Automated pathway and reaction prediction facilitates in silico identification of unknown metabolites in human cohort studies

Identification of metabolites in non-targeted metabolomics continues to be a bottleneck in metabolomics studies in large human cohorts. Unidentified metabolites frequently emerge in the results of association studies linking metabolite levels to, for example, clinical phenotypes. For further analyses these unknown metabolites must be identified. Current approaches utilize chemical information, suc

The GALAH survey : Chemical homogeneity of the Orion complex

Due to its proximity, the Orion star forming region is often used as a proxy to study processes related to star formation and to observe young stars in the environment they were born in. With the release of Gaia DR2, the distance measurements to the Orion complex are now good enough that the 3D structure of the complex can be explored. Here we test the hypothesis that, due to non-trivial structure

State of the Art and Prospects for Halide Perovskite Nanocrystals

Metal-halide perovskites have rapidly emerged as one of the most promising materials of the 21st century, with many exciting properties and great potential for a broad range of applications, from photovoltaics to optoelectronics and photocatalysis. The ease with which metal-halide perovskites can be synthesized in the form of brightly luminescent colloidal nanocrystals, as well as their tunable an

Characterizing Features of Human Circulating B Cells Carrying CLL-Like Stereotyped Immunoglobulin Rearrangements

Chronic Lymphocytic Leukemia (CLL) is characterized by the accumulation of monoclonal CD5+ B cells with low surface immunoglobulins (IG). About 40% of CLL clones utilize quasi-identical B cell receptors, defined as stereotyped BCR. CLL-like stereotyped-IG rearrangements are present in normal B cells as a part of the public IG repertoire. In this study, we collected details on the representation an

Commissioning and operation of the Brazilian synchrotron light source

The Brazilian National Synchrotron Light Laboratory, LNLS, operates a 1.37 GeV electron storage ring with a 120 MeV injector Linac. Commissioning of the storage ring at low energy started on May 1996 and now, an year later, we can store 120 mA at 120 MeV and ramp more than 75 mA to 1.37 GeV. A summary of the latest commissioning results and a description of the present operational performance of t

Breast cancer hormone receptor levels and benefit from adjuvant tamoxifen in a randomized trial with long-term follow-up

BACKGROUND: Hormone receptor positivity predicts benefit from endocrine therapy but the knowledge about the long-term survival of patients with different tumor receptor levels is limited. In this study, we describe the 25 years outcome of tamoxifen (TAM) treated patients.PATIENTS AND METHODS: Between 1983 and 1992, a total of 4,610 postmenopausal patients with early-stage breast cancer were random

Toxicity and complications of preoperative chemoradiotherapy for locally advanced rectal cancer

BACKGROUND: Capecitabine is an attractive radiosensitizer. In this study acute toxicity and surgical complications were evaluated in patients with locally advanced rectal cancer following total mesorectal excision (TME) after preoperative chemoradiotherapy (CRT) with capecitabine.METHODS: Between 2004 and 2008, consecutive patients with clinical tumour category (cT) 3-4 (with a threatened circumfe

Rapid imaging of intravenous gadolinium-based contrast agent (GBCA) entering ventricular cerebrospinal fluid (CSF) through the choroid plexus in healthy human subjects

BACKGROUND: Pathways for intravenously administered gadolinium-based-contrast-agents (GBCAs) entering cerebrospinal-fluid (CSF) circulation in the human brain are not well-understood. The blood-CSF-barrier (BCSFB) in choroid-plexus (CP) has long been hypothesized to be a main entry-point for intravenous-GBCAs into CSF. Most existing studies on this topic were performed in animals and human patient

Diagnostic accuracy of prenatal ultrasound in coarctation of aorta : systematic review and individual participant data meta-analysis

Objective: To determine the diagnostic accuracy of prenatal ultrasound in detecting coarctation of the aorta (CoA). Methods: An individual participant data meta-analysis was performed to report on the strength of association and diagnostic accuracy of different ultrasound signs in detecting CoA prenatally. MEDLINE, EMBASE and CINAHL were searched for studies published between January 2000 and Nove

Evidence for the formation of comet 67p/churyumov-gerasimenko through gravitational collapse of a bound clump of pebbles

The processes that led to the formation of the planetary bodies in the Solar system are still not fully understood. Using the results obtained with the comprehensive suite of instruments onboard the European Space Agency's Rosetta mission, we present evidence that comet 67P/Churyumov-Gerasimenko likely formed through the gentle gravitational collapse of a bound clump of mm-sized dust aggregates ('

Health, cattle and ploughs : Bioarchaeological consequences of the Secondary Products Revolution in southern Sweden, 2300-1100 BCE

In this thesis diet and health of people who lived in southern Sweden 2300-1100 BCE is studied. The study is based on bioarchaeological analyses of human remains from 46 localities in the areas of Uppland, Närke, Östergötland, Västergötland, and Scania. The studies are based on skeletal remains from a minimum number of 310 individuals that have been analysed both osteologically and biochemically.

Risk of diabetes-associated diseases in subgroups of patients with recent-onset diabetes : a 5-year follow-up study

Background: Cluster analyses have proposed different diabetes phenotypes using age, BMI, glycaemia, homoeostasis model estimates, and islet autoantibodies. We tested whether comprehensive phenotyping validates and further characterises these clusters at diagnosis and whether relevant diabetes-related complications differ among these clusters, during 5-years of follow-up. Methods: Patients with new

Olfaction in Desert Locusts- Anatomy, Function and Plasticity of the Central Olfactory System

The anatomy, function and plasticity of the primary olfactory centre, the antennal lobe (AL), of the desert locust Schistocerca gregaria was investigated using a number of neuroanatomical and neurophysiological methods. Anatomical characterisation of the AL in a number of orthopteran species made it possible to deduce a model concerning the evolution of microglomeruli. These neuropil structures, c

Indications and surgical outcome following pulmonary metastasectomy : a nationwide study

AIM: The aim of this retrospective nationwide study was to investigate indications and surgical outcome after pulmonary metastasectomy (PM) in a well-defined cohort of patients and to calculate the proportion of cancer patients who were operated on.METHODS: Between 1984 and 2008, 81 patients (age 54.8 years, 50.6% men) underwent 100 PMs with curative intent in Iceland. For all patients, informatio

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