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A hallmark of parasite infection is the accumulation of innate immune cells, notably granulocytes and mast cells, at the site of infection. While this is typically viewed as a transient response, with the tissue returning to steady state once the infection is cleared, we found that mast cells accumulated in the large-intestinal epithelium following infection with the nematode Trichuris muris and p

Despite intense research, PE_PGRS proteins still represent an intriguing aspect of mycobacterial pathogenesis. These cell surface proteins influence virulence in several pathogenic species, but their diverse and exact functions remain unclear. Herein, we focussed on a PE_PGRS member from Mycobacterium marinum, MMAR_0242, characterized by an extended and unique C-terminal domain. We demonstrate tha

Is there a right to reject mental health care, or may such care be imposed against your will? Human rights law, developed prior to the Convention on the Rights of Persons with Disabilities (CRPD), answered this question with clear authorizations of compulsory interventions under certain circumstances: in essence, when the person has a psychosocial diagnosis, is perceived as in need of medical trea

Wireless ad hoc networks have the last 10 years gained a lot of attention within the research community. A wireless ad hoc network is a special type of wireless network where nodes are typically mobile and doesn’t rely on any fixed infrastructure to operate correctly. Much work has been done on developing robust and stable routing algorithms that consider the dynamic nature of an ad hoc network: n

Hereditary severe combined immunodeficiency (SCID) includes a heterogeneous group of diseases that profoundly affect both cellular and humoral immune responses and require treatment by bone marrow transplantation. Characterization of the cellular and molecular bases of SCID is essential to provide accurate genetic counseling and prenatal diagnosis, and it may offer the grounds for alternative form

OBJECTIVES: Neutrophils are activated and infiltrate the myocardium after ischemia and reperfusion. The involvement of neutrophils in irreversible reperfusion injury is suggested by numerous experimental studies. The aim of this study was to investigate markers of neutrophil activation following reperfusion of acute myocardial infarction (AMI) accomplished with percutaneous coronary intervention (

BACKGROUND. In recent studies serum levels of human glandular kallikrein 2 (hK2) demonstrated significant differences in pathologically organ-confined versus non-organ-confined prostate cancer (Pca). In this study we investigated whether hK2 adds independent information when considered together with traditionally used parameters to predict organ confined (pT2a/b) PCa. METHODS. Serum levels of hK2,

Background: The acceptable noise level (ANL) test is a method for quantifying the amount of background noise that subjects accept when listening to speech. Large variations in ANL have been seen between normal-hearing subjects and between studies of normal-hearing subjects, but few explanatory variables have been identified. Purpose: To explore a possible relationship between a Swedish version of

The paper discusses the modern metropolis as modernity in nucleo. Thereby it refers to notions like state of emergency, provisional realities, crisis, contingency, complexity. Recurrent references include Simmel, Blumenberg, Musil, Park.

The present study examines the discussions about alliance policy in the Swedish council of the realm 1680-1683. Taking issue with earlier research that has portrayed the Swedish foreign policy during this period in realist terms, the study instead uses the concepts of friendship, status and sovereignty to give context to the arguments used by the council when discussing alliance partners. Regardin

“Only in the most technical sense is this a case about who may penetrate whom where. At a practical and symbolical level it is about the status, moral citizenship and sense of self-worth of a significant section of the community.” Justice Albie Sachs, National Coalition for Gay and Lesbian Equality and Another v Minister of Justice and Others 1999 (1) SA 6, para. 107 More than 70 years after th

Digital literacy has become increasingly important. It's often linked to concepts like the information society, which we use to understand the complex changes in ways we socially and economically organize and run society today. The public library is faced with the task of ensuring that the professional skills of their workforce are in line with what is expected – and also interpreting what is

The innate immune system relies to a great deal on the interaction of pattern recognition receptors with pathogen- or damage-associated molecular pattern molecules. Extracellular histones belong to the latter group and their release has been described to contribute to the induction of systemic inflammatory reactions. However, little is known about their functions in the early immune response to an

This article explores three entrepreneurial ventures that have evolved in proximity to online piracy. In reviewing the respective cases of Spotify, Skype, and The Pirate Bay, the argument outlines the radically divergent strategies with which the entrepreneurs have sought to legitimise their ventures and underlying technologies. The article concludes that 1) the context of practices labelled “pira

Background: Basal cell carcinoma (BCC) of the skin is the most common neoplasm among the Caucasian population of the western world. Ultraviolet (UV) radiation-induced p53 activation promotes cutaneous pigmentation by increasing transcriptional activity of pro-opiomelanocortin (POMC) in the skin. Induction of POMC/alpha-melanocyte-stimulating hormone (alpha-MSH) activates the melanocortin 1 recepto

Streptococcus pyogenes is an important human pathogen that causes a variety of diseases including life-threatening invasive diseases, such as toxic shock and deep tissue infections. Although S. pyogenes are classically considered extracellular pathogens, a clinical significance of an intracellular source has been emphasized. In patients with deep tissue infections, an intracellular reservoir of S.