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BMD-Related Genetic Risk Scores Predict Site-Specific Fractures as Well as Trabecular and Cortical Bone Microstructure

CONTEXT: It is important to identify patients at highest risk of fractures. OBJECTIVE: To compare the separate and combined performances of bone-related genetic risk scores (GRSs) for prediction of forearm, hip and vertebral fractures separately, as well as of trabecular and cortical bone microstructure parameters separately. DESIGN, SETTING, AND PARTICIPANTS: Using 1103 single nucleotide polymorp

The impact of tinnitus on n-back performance in normal hearing individuals

Background: Tinnitus sufferers commonly report concentration difficulties. Despite several previous studies investigating this, the underlying cause and the role of hearing status remains unclear. Purpose: To investigate whether there are any differences between normal hearing individuals with and without tinnitus in terms of working memory capacity, and whether working memory capacity correlates

A value mapping tool for sustainable business modelling

Purpose: Although business models that deliver sustainability are increasingly popular in the literature, few tools that assist in sustainable business modelling have been identified. This paper investigates how businesses might create balanced social, environmental and economic value through integrating sustainability more fully into the core of their business. A value mapping tool is developed t

A new evolutionary rough fuzzy integrated machine learning technique for microRNA selection using next-generation sequencing data of breast cancer

MicroRNAs (miRNA) play an important role in various biological process by regulating gene expression. Their abnormal expression may lead to cancer. Therefore, analysis of such data may discover potential biological insight for cancer diagnosis. In this regard, recently many feature selection methods have been developed to identify such miRNAs. These methods have their own merits and demerits as th

Movements of the wrist and the risk of carpal tunnel syndrome : A nationwide cohort study using objective exposure measurements

Objectives: We conducted a large cohort study to investigate the association between work-related wrist movements and carpal tunnel syndrome (CTS). Methods: Electro-goniometric measurements of wrist movements were performed for 30 jobs (eg, office work, child care, laundry work and slaughterhouse work). We measured wrist angular velocity, mean power frequency (MPF) and range of motion (ROM). We es

Evolution of star clusters in arbitrary tidal fields

We present a novel and flexible tensor approach to computing the effect of a time-dependent tidal field acting on a stellar system. The tidal forces are recovered from the tensor by polynomial interpolation in time. The method has been implemented in a direct-summation stellar dynamics integrator (NBODY6) and test-proved through a set of reference calculations: heating, dissolution time and struct

Research protocol for mechanical complications after central venous catheterisation : a prospective controlled multicentre observational study to determine incidence and risk factors of mechanical complications within 24 hours after cannulation

INTRODUCTION: Central venous catheterisation is a common procedure in intensive care therapy and the use of central venous catheters is essential for treatment of many medical disorders. Although rare, central venous catheterisation is associated with mechanical complications that can be life-threatening if untreated. Real-time ultrasound guidance reduces the incidence of mechanical complications

Romanising the mountains? Exploring cultural change through archaeological spatial analysis in Western Sierra Morena (Spain)

Western Sierra Morena constitutes a singular link between the Roman provinces of Baetica and Lusitania, in terms of its physiography and historical development. This region, characterised by its rugged topography, forests, and abundant mineral resources, was decisively transformed after the Roman conquest. Such transformations are visible in the characteristics of the archaeological record and in

Between Religious Studies, Religious Education, Teaching Education, and Religion and Education : Relationships, Opportunities, Tensions

The aim of the present paper is to explore the interrelated and complex relationships between religionsvetenskap (Religious Studies), religionskunskap (Religious Education) and religionsdidaktik (Religion and Education). After briefly outlining the concurrent developments of Religious Studies as a university discipline and Religion and Eudcation as a non-confessional school subject, both of which

Gamification in Politics

Although gamification is a popular term, the concept has rarely been applied to political studies. Therefore, this chapter provides an overview of the key features of gamification and offers an adapted definition of gamification suited to the study of electoral politics. To help illustrate this definition, two examples of gamification from recent campaigns are discussed: the uCampaign mobile appli

Oxygen targets and 6-month outcome after out of hospital cardiac arrest : a pre-planned sub-analysis of the targeted hypothermia versus targeted normothermia after Out-of-Hospital Cardiac Arrest (TTM2) trial

Background: Optimal oxygen targets in patients resuscitated after cardiac arrest are uncertain. The primary aim of this study was to describe the values of partial pressure of oxygen values (PaO2) and the episodes of hypoxemia and hyperoxemia occurring within the first 72 h of mechanical ventilation in out of hospital cardiac arrest (OHCA) patients. The secondary aim was to evaluate the associatio

Efficient Encapsulation and Controlled Release of N,N-Diethyl-3-methylbenzamide (DEET) from Oil-in-Water Emulsions Stabilized by Cationic Nanocellulose and Silica Nanoparticles

Oil-in-water emulsions containing N,N-diethyl-3-methylbenzamide (DEET) were developed aiming to extend the sustained release of the active compound, by using two oppositely charged nanomaterials, namely silica nanoparticles (SiNP) and cationic cellulose nanofibrils (CCNF), as stabilizers, and a mixture of food-grade nonionic surfactants to avoid precipitation by electrostatic aggregation. The form