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Tumor cells secreting IL-1 beta are invasive and metastatic, more than the parental line or control mock-transfected cells, and concomitantly induce in mice general immune suppression of T cell responses. Suppression strongly correlates with accumulation in the peripheral blood and spleen of CD11b(+)/Gr-1(+) immature myeloid cells and hematological alterations, such as splenomegaly, leukocytosis,

Complement deficiencies are probably vastly under-diagnosed within clinical medicine. Judging from a Swedish study of C2 deficiency, a deficiency with an estimated prevalence of about 1/20,000 in Western countries, less than 10% of the deficiencies of the classical and alternative pathways and the late complement components are identified in Sweden. C1 inhibitor deficiency and deficiencies of MBL

The growing field of biotechnology is in constant need of binding proteins with novel properties. Not just binding specificities and affinities but also structural stability and productivity are important characteristics for the purpose of large-scale applications. In order to find such molecules, libraries are created by diversifying naturally occurring binding proteins, which in those cases serv

The objective of this study was to investigate B-lymphocyte reconstitution in patients undergoing allogeneic haematopoietic stem cell transplantation (HSCT) after myeloablative conditioning (MAC) or reduced-intensity conditioning (RIC) regimens. B-lymphocyte reconstitution was studied by monitoring the CDR3 repertoire with spectratyping. We demonstrate a delay in the recovery of the B-lymphocyte r

Purified polyclonal immunoglobulin preparations representing the 4 rat IgG subclasses were tested for binding to Staphylococcus aureus protein A attached to 3 different solid phases (Staphylococcus aureus Cowan I bacteria, Sepharose CL4B and Sepharose 6MB). Protein A Sepharose CL4B showed higher reactivity with IgG1 and IgG2b than the staphylococci, whereas protein A Sepharose 6MB showed a lower u

The paper discusses dynamic real-time scheduling in the context ofmodel predictive control (MPC). Dynamic scheduling in this settingis motivated by the highly varying execution times associated withMPC controllers. Premature termination of the optimization algorithmis exploited to trade off prolonged computations versuscomputational delay. A feedback scheduling strategy for multiple MPCcontrollers

Periodontitis is an inflammatory disease of the supporting structures of the teeth and is caused by, among other agents, Porphyromonas gingivalis. P. gingivalis is very resistant to killing by human complement, which is present in a gingival fluid at 70% of the serum concentration. We found that the incubation of human serum with purified cysteine proteases of P. gingivalis (gingipains) or P. ging

This thesis is based upon four original papers describing the characterisation of mantle cell lymphoma (MCL) tumours and cell lines in comparison with different populations of normal B cells. Gene expression profiling, which were used in the studies, has during recent years developed as an important tool in characterisation of different types of malignancies. In this thesis, the technique is used

Desalting technologies and fresh water production has been developed over the years, including primarily thermal and membrane processes. Five different types of desalination technology were studied and compared for long-term of use namely, thermal processes include multistage flash evaporation (MSF), multiple effect evaporation (ME), and vapor compression (VC) and membrane processes contain revers

As Syria’s anti-authoritarian uprising and subsequent civil war have left the country in ruins, the need for understanding the nation’s complex political and cultural realities remains urgent. The second of a two-volume series, Syria from Reform to Revolt: Culture, Society, and Religion draws together closely observed, critical and historicized analyses, giving vital insights into Syrian society t

New institutional theory has been critizised, for describing institutionalization as a static qualitative state rather than a process. In this paper we provide an extended understanding of the process of institutionalization by replacing the mechanical concept of diffusion by the concept of translation and an analytical model of "trevel of ideas". Analyzing the field material from three cases of t

Presents an iterative approach to optimal control when modeling errors are present. The problem considered is movement of open containers containing liquid in an industrial packaging machine. The goal is to move as fast as possible without too much slosh. There is no measurement of the slosh available in the machine, therefore open loop control via the acceleration reference is the only possibilit

Transient electromagnetic wave propagation in a stratified, anisotropic, dispersive medium is considered. Specifically, the direct scattering problem is addressed. The dispersive, anisotropic medium is modeled by constitutive relations (a 3 3 matrix-valued susceptibility operator) containing time convolution integrals. In the general case, nine different susceptibility kernels characterize the med

Popular Abstract in Swedish För att en multicellulär organism som männinskan ska kunna fungera måste celldelningen strikt kontrolleras. Protein som reglerar celldelning på cellulär nivå kallas för "tillväxtfaktorer". Vi har studerat ett sådant protein som kallas för transforming growth factor-beta (TGF-b). Namnet TGF-b kommer sig utav att detta protein kan transformera (omvandla) epiteliala njurceTransforming growth factor-beta (TGF-b) is a well-characterised growth regulatory factor, which acts on most cell types. This thesis has focused on the regulatory roles of TGF-b on normal lymphocytes. One interesting finding is that TGF-b acts both costimulatory and inhibitory on T-lymphocytes. The costimulatory effect depends on the presence of monocytes and is mediated by these cells. Furthermor

We explain autonomy with full-fledged reference to the complementaristic conception of language and its introspective capabilities. This field that we refer to is understood to belong to a wider epistemic category than that of (the received view of) semiotics as well as of systems science. It follows from the linguistic complementarity that autonomies (self-references; independencies) can never be