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Gene amplification is a crucial process in cancer development, leading to the overexpression of oncogenes. It manifests cytogenetically as extrachromosomal double minutes (dmin), homogeneously staining regions (hsr), or ring chromosomes (r). This study investigates the prevalence and distribution of these amplification markers in a survey of 80 131 neoplasms spanning hematologic disorders, and ben
This study presents a thermodynamically consistent continuum damage model for fiber-based materials that combines elastoplasticity and damage mechanisms to simulate the nonlinear mechanical behavior under in-plane loading. The anisotropic plastic response is characterized by a non-quadratic yield surface composed of six sub-surfaces, providing flexibility in defining plastic properties and accurac
This chapter presents the personal experiences of an activist researcher. It describes the role of activism in Gaborit's trajectory from being a student research assistant, through PhD candidate to postdoctoral fellow, and finally, to breaking with academia. This chapter discusses the inherent contradictions of working against hegemonic structures that enable social harm, from within the hegemonic
AIMS: Patients with arrhythmogenic right ventricular cardiomyopathy (ARVC) have increased prevalence of atrial arrhythmias indicating atrial involvement in the disease. We aimed to assess the long-term evolution of P-wave indices as electrocardiographic (ECG) markers of atrial substrate during ARVC progression. METHODS AND RESULTS: We included 100 patients with a definite ARVC diagnosis according
The Covid-19 pandemic has had a huge influence in almost all areas of life, affecting societies, economics and health care systems worldwide. The paediatric cardiology community is no exception. As the challenging battle with Covid-19 continues, professionals from the Association for the European Paediatric and Congenital Cardiology (AEPC) receive many questions regarding Covid-19 in a Paediatric
Ljungan virus (LV), a Parechovirus of the Picornavirus family, first isolated from a bank vole at the Ljungan river in Sweden, has been implicated in the risk for autoimmune type 1 diabetes. An assay for neutralizing Ljungan virus antibodies (NLVA) was developed using the original 87-012 LV isolate. The goal was to determine NLVA titres in incident 0-18 years old newly diagnosed type 1 diabetes pa
Purpose: The aim of this study is to explore teachers’ experience and understanding of classroom communication after participating in a speech-language pathologist (SLP) led in-service training on classroom communication. Method: This qualitative study used a focus group approach to explore how teachers describe their classroom communication. Twenty primary-school teachers participated. Thematic a
The response of soft colloids to crowding depends sensitively on the particles' compressibility. Nanogel suspensions provide model systems that are often studied to better understand the properties of soft materials and complex fluids from the formation of colloidal crystals to the flow of viruses, blood, or platelet cells in the body. Large spherical nanogels, when embedded in a matrix of smaller
Food security assessment in sub-Saharan Africa requires simultaneous consideration of multiple socio-economic and environmental variables. Early identification of populations at risk enables timely and appropriate action. Since large and widely dispersed populations depend on rainfed agriculture and pastoralism, climate monitoring and forecasting are important inputs to food security analysis. Sat
Background: Primary hyperparathyroidism (pHPT) is caused by single- or multiglandular disease (MGD). Patients with MGD have an increased risk of complications at surgery and for persistence and recurrence after surgery. The study evaluated whether preoperative clinical and biochemical characteristics could predict MGD in patients with pHPT. Methods: We retrospectively evaluated patients operated 1
Immune checkpoint inhibitors (ICIs) have received much attention not least for melanoma since the award of the Nobel prize in 2018. Here, we review the current state of knowledge about the use of these monoclonal antibodies (mAbs) in non-small cell lung cancer (NSCLC). These drugs have generally been conditionally approved on limited early data and there are few long-term follow-up data from rando
Infections are associated with increased risk of MPO- but not PR3-ANCA-associated vasculitis - a population-based case-control study from southern sweden
Humanity is facing increasingly complex sustainability challenges. It is now clear that they cannot be resolved by new technology, policy or governance approaches alone. They require a broader, cultural shift. Consequently, the role of human beings' "inner dimensions" (e.g., their mindsets, worldviews, beliefs, social values, and motivations) and their potential "inner transformation" (embodied in
Inference of antibody gene repertoires using transcriptome data has emerged as an alternative approach to the complex process of sequencing of adaptive immune receptor germline gene loci. The diversity introduced during rearrangement of immunoglobulin heavy chain variable (IGHV), diversity, and joining genes has however been identified as potentially affecting inference specificity. In this study,
The circulating zymogen form of Factor VII activating protease (FSAP) can be activated by histones and nucleosomes in vivo. These cell-death-associated nuclear factors are also actively extruded into the extracellular space by neutrophils through a process called neutrophil extracellular trap (NET) formation (NETosis). NETs are thought to be involved in host defense, inflammation as well as thromb
Objective: Atypical responses to sensory stimuli are common features of autism spectrum disorders (ASD). Consequently, atypical sensory reactivity (SR) is now a diagnostic feature of ASD. Quantitative genetic research on ASD has overlooked these symptoms, however. We therefore investigated the association between autistic traits and SR using twin methods. Method: Autistic traits and SR were assess
Methods for monitoring seepage are important for dam safety of embankment dams. Increased seepage may be associated with internal erosion in the dam, and internal erosion is one of the main reasons for dam failures. Internal erosion progresses inside the dam, and is difficult to detect by conventional methods. Therefore, there is a need for new or improved methods. The resistivity method is a non-
This paper reports results of two experiments (phonetic production experiment and self-paced perception experiment) on what we call nuclear prominence in Japanese. The goal of this study is two-fold. First, through a production experiment (Experiment 1), we attempt to provide quantitative confirmation of the presence of nuclear prominence in Japanese, which has only been sporadically and informall
