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We all are accustomed to projects. Projects are everywhere, and everything is basically a project. We have learnt how to deal with projects, for better or worse. Some of us love them, some of us are fed up with them. But projects are here to stay. Projects are far from a new invention, what has changed is the fine-tuning. It has changed to the point that projects of today are virtually unrecognisa

Uncertainty analysis is important for wastewater treatment plant (WWTP) model applications. An important aspect of uncertainty analysis is the identification and proper quantification of sources of uncertainty. In this contribution, a methodology to identify an ensemble of behavioural model representations (combinations of input data, model structure and parameter values) is presented and evaluate

Most models of sedimentation contain the nonlinear hindered-settling flux function. If one assumes ideal conditions and no compression, then there exist several theoretically possible ways of identifying a large portion of the flux function from only one experiment by means of formulas derived from the theory of solutions of partial differential equations. Previously used identification methods an

Introduction. Anti-neutrophil cytoplasmic antibodies specific for bactericidal/permeability-increasing protein (BPI-ANCA) are frequent in CF patients and mainly develop in response to infection with Pseudomonas aeruginosa. It is not known to what extent BPI-ANCA correlates to prognosis. Objectives. To evaluate the prognostic value of IgA-BPI-ANCA, measured at the beginning of the study, for transp

Cosmological long-duration gamma-ray bursts (LGRBs) are thought to originate from the core collapse to black holes (BHs) of stripped massive stars. Those with sufficient rotation form a centrifugally supported torus whose collapse powers the GRB. We investigate the role of tidal locking within a tight binary as a source of the necessary angular momentum. We find that the binary orbit must be no wi

Purified, recombinant M12 protein from Streptococcus pyogenes CS24 has recently been demonstrated to bind human immunoglobulin G3 (IgG3). The binding site for IgG has been localized to an internal peptide encoded by a PvuII fragment of the gene emm12. We have investigated the ability of an isolated recombinant M12 protein consisting of the peptide encoded by the PvuII fragment to bind various mono

Positional cloning of the underlying genes for the rare syndrome autoimmune polyendocrinopathy candidadiasis extrodermal dystrophy (APECED) opened a new venue of research on the role of central tolerance in autoimmunity. The associated autoimmune regulator gene (AIRE), was found to be expressed in medullary thymus epithelial cells (mTEC) in both man and mice, and to control promiscuous expression

Background: Previous work has demonstrated immunomodulatory, anti-tumor, anti-metastatic and anti-angiogenic effects of the small molecule quinoline-3-carboxamide tasquinimod in pre-clinical cancer models. To better understand the anti-tumor effects of tasquinimod in transplantable tumor models, we have evaluated the impact of the compound both on recruitment of myeloid cells to tumor tissue and o

Observations of high-redshift galaxies have revealed a multitude of large clumpy rapidly star-forming galaxies. Their formation scenario and their link to present-day spirals are still unknown. In this Letter, we perform adaptive mesh refinement simulations of disc formation in a cosmological context that are unrivalled in terms of mass and spatial resolution. We find that the so-called 'chain-gal

Organizational image is a contested concept in interdisciplinary research, drawing upon organizational communication, corporate communication, organization, marketing, and public relations studies. As such, organizational image is seen as the impression of an organization that exists among both external stakeholders as well as organizational members themselves as “construed external images” and “d

For centuries antiquarians and archaeologists have tried to reconcile the terminology of ancient writers on architecture, such as Vitruvius, with the perceived realities of the material record. One particular issue of debate concerns the interpretation of different words for "brick" in Latin. In this paper it is argued that earlier attempts to settle this question are unsatisfactory and leave seve