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The prevailing model for adult hematopoiesis postulates that the first lineage commitment step results in a strict separation of common myeloid and common lymphoid pathways. However, the recent identification of granulocyte/monocyte (GM)-lymphoid restricted lymphoid-primed multipotent progenitors (LMPPs) and primitive common myeloid progenitors (CMPs) within the "HSC" compartment provide compellin
Thymic expression of insulin has been suggested to play a major role in negative selection of autoreactive T cells and tolerance induction against pancreatic beta cells. Furthermore, the expression of insulin in peripheral antigen-presenting cells (APC) has been clearly demonstrated but whether thymic negative selection and tolerance induction also depends on peripheral influx of self-antigens (Ag
The article provides an overview of ongoing research and key characteristics of Cognitive Semiotics, an emerging field dedicated to the transdiciplinary study of meaning, involving above all researchers from semiotics, linguistics, developmental and comparative psychology and philosophy. The combination of the following features distinguishes it from other synthetic approaches: (a) integration of
PRELP is a member of the leucine-rich repeat family of extracellular matrix proteins in connective tissue. In contrast to other members of the family, the amino-terminal domain of PRELP has a high content of proline and positively charged amino acids. This domain has previously been shown to bind chondrocytes and to inhibit osteoclast differentiation. Here we show that PRELP mediates cell adhesion
Mixtures of an amphiphilic graft copolymer in water/sodium bis(2-ethylhexyl) sulfosuccinate (AOT)/cyclohexane oil-continuous microemulsions are studied by the PGSE NMR technique and by viscometry. The graft copolymer has an oil-soluble poly(dodecyl methacrylate) backbone and water-soluble poly(ethylene glycol) side chains. Water, surfactant, and polymer self-diffusion coefficients can be measured
The aim of this study was to analyze the added utility of contrast administration for spine MRI in children with scoliosis. A retrospective review of 663 consecutive contrast-enhanced spine MRI performed in 319 patients as part of the work up of scoliosis in children 2-18 years with clinically suspected or known scoliosis over a seven year period. Those patients with known tumors (13 patients) bei
Location management in cellular networks have been in focus for the research community for a number of years. The current static method of determining location or paging areas has been shown to be sub- optimal and costly for operators. Therefore, much research has been focussed on dynamic schemes, which show great promise in cost optimisation. However, the research has still been focussed on aggre
The cognitive- and neuro-sciences have supposed that the perceptual world of the individual is dominated by vision, followed closely by audition, but that olfaction is merely vestigial. Aslian-speaking communities (Austroasiatic, Malay Peninsula) challenge this view. For the Jahai — a small group of rainforest foragers — odor plays a central role in both culture and language. Jahai ideology revolv
Mobility, quality of service (QoS) support, and multicast routing capability are important requirements for today’s networks. This is a result of the changes in wireless users’ expectations, which favour group-oriented, high-quality, multimedia communication. Ad hoc networks enhanced with QoS multicasting strategies can provide users with these features. This paper defines the building blocks of a
Abstract is not available.
Despite the perceived role of retailers to realize corporate supply chain responsibility, retailers face a number of structural and managerial challenges to effectively influence the sustainability parameters in upstream supply chain. At the same time, research that touches upon implementation of sustainable sourcing by food retailers is limited leaving aside the inter-organisational managerial im
Human x mouse hybridoma cells were grown in dialysis tubing (DT) to obtain large quantities of human monoclonal antibodies (MAb). Hybridoma cells were grown inside the DT, which was placed in a tissue culture flask containing medium. The medium inside the DT was supplemented with different additives which may be selected depending on the intended use of the MAb. About 10-50 times higher concentrat
