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A previous study compared two student groups that played a mathematics game based on a teachable agent. One group played with, and the other without, the inclusion of a social conversation module: a chat between the student and the teachable agent. Results were that students who used the game with the chat included had a more positive experience of the game and learned more in the sense of teachin
In Huntington's disease (HD), cognitive symptoms and cellular dysfunction precede the onset of classical motor symptoms and neuronal death in the striatum and cortex by almost a decade. This suggests that the early cognitive deficits may be due to a cellular dysfunction rather than being a consequence of neuronal loss. Abnormalities in dendritic spines are described in HD patients and in HD animal
Here a synthesis of novel galactose-1,2,3-triazole conjugates is described. The title compounds were obtained from 3-azido-3-deoxy-1,2: 5,6-di-O-isopropylidene-α-D-galactofuranose via a copper catalyzed azide-alkyne 1,3-dipolar cycloaddition reaction. It was demonstrated that the title compounds in their isopropylidene-protected form tend to chelate copper. The copper content can be diminished to
Antibody-based microarrays is a novel technology with great promise for high-throughput proteomics. The process of designing high-performing arrays has, however, turned out to be challenging. Here, we have designed the next generation of a human recombinant scFv antibody microarray platform for protein expression profiling of nonfractionated biotinylated human plasma and serum proteomes. The setup
The BRCA1 gene is thought to exert its main function early in life. We, therefore, studied the effects of BRCA1 mutations on birth weight and birth length. This was carried out by comparing 33 women with and without mutations. Birth weight and length were obtained from a self-administered questionnaire. BRCA1 mutations carriers had a significantly lower birth weight (P = 0.0041) compared with non-
Dendritic cells (DCs) operate as the link between innate and adaptive immunity. Their expression of pattern recognition receptors (PRRs), such as TLRs and CLRs, enable antigen recognition and mediate appropriate immune responses. Distinct subsets of human DCs have been identified; however their PRRs expressions are not fully clarified. Especially, expressions of CLRs by DC subpopulations remain el
The placenta must not only provide nutrients and take care of fetal waste products, it also needs to protect the fetus from maternal immunological attacks while at the same time transmitting maternal immunoglobulins to ensure protection against infectious agents.
Popular Abstract in Swedish Det finns en skillnad mellan historia som vetenskap och historia som historiskt minne, som boken vill fästa uppmärksamhet på. Ådalen som motbild till det trygga Folkhemmet är en bild av hur vi kan uppleva verkligheten. Inte nödvändigtvis hur den såg ut. Vår uppfattning om vad som hänt kan vaa nog så verklig när vi handlar, agerar och tolkar omvärlden. Det är denna tolknThe prelude to this thesis is provided by the dramatic scenes that took place in Ådalen. During a demonstration, four men and one young woman were shot to death and five others injured by military troops ordered to Lunde harbour. Inspired by a number of other researchers (Koselleck, Samuel, Somers, Stråth, Södring, Jensen and Burke, to name a few), my investigation has analysed how the story of th
It is argued that evolution goes beyond that which can be described in a well-defined language) and that it instead enforces a language that is itself evolving. Evolution is the unfolding of this self-reference. The unfolding methodology of the logician Alfred Tarski is taken as a basis for the explicability of evolution. Looking at Tarski´s results as a linguistic complementarity, we get a view w
Popular Abstract in Swedish Multikonjugerad Adaptiv Optik för Astronomiska Teleskop 1. Atmosfärisk turbulens Allt sedan man på 1600-talet började bruka optiska instrument inom astronomin, för att understödja det mänskliga ögat då man beskådade stjärnhimlen, har astronomer strävat efter att bygga allt större och bättre teleskop för att kunna se längre ut i rymden och skönja allt ljussvagare objekt.This work analyses several aspects of multi-conjugate adaptive optics (MCAO) for astronomy. The research ranges from fundamental and technical studies for present-day MCAO projects, to feasibility studies of high-order MCAO instruments for the extremely large telescopes (ELTs) of the future. The first part is an introductory exposition on atmospheric turbulence, adaptive optics (AO) and MCAO, esta
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Popular Abstract in Swedish Människor (och andra arter) har en grundläggande förmåga att anpassa sig till och lära sig hur omgivningen är strukturerad. Ofta lär vi oss struktur indirekt, utan att direkt och avsiktligt studera strukturen ifråga. Klassiska vardagsexempel på tämligen oavsiktlig strukturinlärning är språkinlärning, utveckling av musikaliska preferenser, inlärning av sociala regler, ocPeople can become sensitive to the general structure of different parts of the environment, often without studying that general structure directly, but through being incidentally exposed to instances that conform to the structure. When such learning proceeds unintentionally and gives rise to knowledge that is difficult to verbalize it is often referred to as implicit learning. One of the most comm
