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OBJECTIVES: The cell cycle regulator cyclin D1 plays an important role in parathyroid tumourigenesis. The NciI polymorphism in exon 4 has recently been associated with early onset of hereditary nonpolyposis colorectal cancer and is a prognostic indicator of nonsmall cell lung cancer and squamous cell carcinomas. Furthermore, a limited study of 28 primary hyperparathyroidism (pHPT) patients display
Vitamin D receptor (VDR) and 25-hydroxyvitamin D3 1-alpha-hydroxylase expression have recently been shown to be upregulated in several tumors and thought to represent an important endogenous response to tumor progression. Little is known about the expression of these proteins in thyroid carcinoma, although previous reports have documented evidence of the biological effect of vitamin D in thyroid c
There is currently no international consensus on how human germline engineering should be regulated. Existing national legislation fails to provide the governance framework necessary to regulate germline engineering in the CRISPR era. This is an obstacle to scientific and clinical advancements and inconsistent with human rights requirements. To move forward, we suggest that the human right to scie
This article surveys the politics of plastics through a reading and analysis of more than 180 scientific articles in the fields of environmental science and environmental studies. Despite the many benefits of plastics, the global plastic system is increasingly being recognized as the source of severe environmental problems. Rather than orient the investigation around specific venues, levels, or ar
This retrospective study sought to determine the safety and effectiveness of flecainide in children with normal hearts and those with congenital heart disease (CHD) or cardiomyopathy (CMO). Baseline and follow-up data at two pediatric cardiology sites were queried (2000–2015); a total of 175 patients (20 with CHD and two with CMO) receiving flecainide were assessed. When comparing patients with CH
This thesis consists of three self-contained papers studying different topics in health economics. The first chapter studies the substitution effect between in-person physician visits and a new type of doctor visits, direct-to-consumer (DCT) telemedicine, where a person can call a doctor directly via an app. To causally assess to which degree DCT consultations substitute for in-person consultation
This article considers the political implications of Victorian language-study for Thomas Carlyle's The French Revolution (1837) (reprinted and edited by K.J. Fielding and David Sorensen (Oxford: Oxford World's Classics, 1989)). I investigate how Carlyle responded to the scientific study of language with what he termed a ‘bodied word’, a reading of language based in the word-become-flesh or the doc
The cause of massive blooms of Ethmodiscus rex laminated diatom mats (LDMs) in the eastern Philippine Sea (EPS) during the Last Glacial Maximum (LGM) remains uncertain. In order to better understand the mechanism of formation of E. rex LDMs from the perspective of dissolved silicon (DSi) utilization, we determined the silicon isotopic composition of single E. rex diatom frustules (δ30SiE. rex) fro
Substantial variability exists in what pathologists consider as pT4a in colorectal cancer when tumor cells are within 1 mm of the free peritoneal surface. This study aimed to determine if the measured sub-millimeter distance between tumor cells and the free peritoneal surface would offer an objective means of stratifying patients according to the risk of developing peritoneal metastases. Histologi
Introduction: The Swedish Agency for Work Environment Expertise commissioned researchers atLund University, Kristianstad University and Malmö University to conduct a systematic reviewfocusing on the impact of the psychosocial work environment on the senior workforce (≥55 years ofage) in a Swedish context.Aims: To provide an overview of how psychosocial work environment and occupational healthfacto
This article examines the political economy of Arab-Israeli peacemaking in the first half of the 1990s, specifically the multilateral working group on Arms Control and Regional Security (ACRS). It focuses on the misplaced memorialization of the ACRS process as a lost opportunity for the establishment of a nuclear weapons free zone (NWFZ) in the Middle East, which has resulted in a continuous “retu
Respublica Litteraria in Action: Travels--Maps--Itineraries, ed. Katarzyna Tomaszuk. Supplement: Patryk Sapała, The Itinerary of Bishop Piotr Tomicki, Vice-Chancellor of the Kingdom of Poland (1515-1535), Warsaw: University of Warsaw Press, 2023 (series: Corpus Epistularum Ioannis Dantisci, part V: Respublica Litteraria in Action, vol. 4).
Aims. The aim of this work is to create a complete list of sources exhibiting a long secondary period (LSP) in the ASAS-SN catalog of variable stars, and analyze the properties of this sample compared to other long period variables without an LSP. Methods. We used the period-amplitude diagram to identify the 55 572 stars showing an LSP, corresponding to 27% of the pulsating red giants in the catal
