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Evolutionary changes in populations of microbes, such as microalgae, cannot be traced using conventional metabarcoding loci as they lack intraspecific resolution. Consequently, selection and competition processes among strains of the same species cannot be resolved without elaborate isolation, culturing, and genotyping efforts. Bamboozle, a new bioinformatic tool introduced here, scans the entire
Background/Objectives: Fertility-sparing surgery (FSS) is a standard practice for managing early stage cervical cancer, yet significant variation exists in clinical approaches worldwide. Our objective was to ascertain current practices and preferences for cerclage use among expert centers globally regarding FSS in patients with early stage cervical cancer. Methods: We conducted a cross-sectional s
Micro-scale mechanisms, such as inter-particle and particle-fluid interactions, govern the behaviour of granular systems. While particle-scale simulations provide detailed insights into these interactions, their computational cost is often prohibitive. At a recent Lorentz Center Workshop on “Machine Learning for Discrete Granular Media”, researchers explored how machine learning approaches can aid
The side-feeding patterns and the spectra of unresolved γ-lines are calculated for Gd, Dy and Er nuclei with neutron numbers from 82 to 86. Energies and configurations for states from the yrast line and approximately 2 MeV higher in energy are calculated as many-quasiparticle configurations in a deformed oblate potential. The γ-cascade is simulated by a Monte Carlo calculation. With a common avera
Autonomy is central to thinking about democracy and human needs, but the question of how autonomy relates to growth is ambivalent. Is growth necessary to achieve a basic level of autonomy, or is autonomy, in fact, a pre-requisite for post-growth? In this study, we examine this question by focusing on how critical autonomy relates to growth within the domains of democracy, education, and work. Crit
Vehicle models are often bound by non-disclosure agreements with manufacturers.This thesis presents a vehicle model based on vehicle data gathered for the NationalAdvanced Driving Simulator in Ohio and therefore it is not bound by such limitationsand can be used in future research projects.The development and validation of the vehicle model requires understanding of thesubsystems studied, componen
The binder plays a crucial role in maintaining the integrity and enhancing the conductivity of the electrode, although it accounts for a small weight fraction in the entire electrode. However, the conventional binder used in lithium-sulfur (Li-S) batteries fails to effectively tackle the challenges posed by the shuttle effect of lithium polysulfides, as well as the issues of poor conductivity and
The morphogenetic protein DivIVA exhibits diverse functions across bacterial phyla. In Bacillota, DivIVA is primarily involved in cell division, whereas in Actinomycetota, it plays a central role in coordinating polar growth. Due to its essentiality in Actinomycetota, gaining insight into its structural functions is challenging. We studied truncated DivIVA proteins using a unique divIVA deletion m
Cellular senescence, a phenomenon characterized by the accumulation of dysfunctional, metabolically active cells, is increasingly recognized to be a key player in aging-related metabolic disorders. It is accelerated by hyperglycemia through various molecular pathways, positioning it as a critical mechanism in the pathophysiology of type 2 diabetes mellitus (T2D) and a potential therapeutic target.
Climate warming is expected to influence the prevalence of vector-transmitted parasites. Understanding the extent to which this is ongoing, or has already occurred, requires empirical data from populations monitored over long periods of time, but these studies are sparse. Further, vector-disease research involving human health is often influenced by disease control efforts that supersede natural t
Background: Endocrine science remains underrepresented in European Union research programmes despite the fundamental role of hormone health in human wellbeing. Analysis of the CORDIS database reveals a persistent gap between the societal impact of endocrine disorders and their research prioritisation. At national funding level, endocrine societies report limited or little attention of national res
Mantle cell lymphoma (MCL) is a relatively rare B-cell lymphoma subtype, with a higher incidence among males and a median age of 70 years at diagnosis. MCL is characterized by clinically diverse behavior, from indolent disease to extremely aggressive, related to the presence of biological risk factors such as proliferation rate and TP53 mutations. Most often, patients present with disseminated dis
Ever-increasing global water shortages necessitate more advanced and cost-effective water purification methods. Herein, a novel slow filtration system using natural raw zeolite is proposed as an alternative to traditional quartz sand as a filter medium. The system demonstrates excellent performance in reducing turbidity and removing methylene blue (MB). The natural zeolite-based filtration system
Background and Objectives: Previous studies have suggested associations between pain perception and psychological factors such as mood, distress, fatigue, and quality of life. However, these factors and their relationship to pain sensitivity have typically been investigated in isolation and with insufficient sample sizes. To address these limitations, we examine the interplay between distinct psyc
Considering the distinct etiological pathways and molecular characteristics of different lung cancer subtypes, it is crucial to develop subtype-specific prevention strategies and therapeutic targets. This study aimed to identify protein biomarkers and potential therapeutic targets for specific subtypes of lung cancer by integrating population-based observational studies and Mendelian randomisation
The special degeneracy which occurs in the harmonic-oscillator potential when two of the frequencies have ratios of small integer numbers is exploited. Favored shell energies occur for particle numbers which vary with the third frequency. Applications to realistic nuclear potentials show that this degeneracy leads to special shell effects for axial shapes (1:1 ratio) but also for the 2:1 ratio exe
Integrated Continuous Biomanufacturing reduces manufacturing costs while maintaining product quality. A key contributor to high biopharmaceutical costs, specifically monoclonal antibodies (mAbs), is chromatography. Protein A ligands are usually preferred but still expensive in the manufacturing context, and batch chromatography under-utilizes the columns' capacity, compromising productivity to mai
