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Blood biomarkers indicative of Alzheimer’s disease (AD) pathology are altered in both preclinical and symptomatic stages of the disease. Distinctive biomarkers may be optimal for the identification of AD pathology or monitoring of disease progression. Blood biomarkers that correlate with changes in cognition and atrophy during the course of the disease could be used in clinical trials to identify
This report proposes a capability assessment framework for countering disinformation, information influence, and foreign interference. At present, much emphasis is placed on the capability to counter disinformation and other associated phenomena. However, few have attempted to systematically define what those countermeasures are, and how they could be placed within a single, coherent capability as
The Global Hyperorgan is an intercontinental, creative space for acoustic musicking. Existing pipe organs around the world are networked for real-time, geographicallydistant performance, with performers utilizing instruments and other input devices to collaborate musically through the voices of the pipes in each location. A pilot study was carried out in January 2021, connecting two large pipe org
By 2050, seven billion people will be living in cities. In 2020 itself, these cities dumped a whopping 29 trillion tonnes of carbon dioxide into the atmosphere. This carbon dioxide along with other greenhouse gases poses a serious health hazard. It also manifests as extreme weather events, leading to the loss of lives, livelihoods, assets, and social wellbeing.Given the significant impact that cit
Analysis of an individual's immunoglobulin or T cell receptor gene repertoire can provide important insights into immune function. High-quality analysis of adaptive immune receptor repertoire sequencing data depends upon accurate and relatively complete germline sets, but current sets are known to be incomplete. Established processes for the review and systematic naming of receptor germline genes
Share and repair organizations (SROs) have important implications for resource efficiency and socio-economic sustainability in cities, but their potential to contribute to long-term urban resilience has yet to be systematically investigated. Knowledge is scarce about how these nascent circular initiatives can provide building blocks for socio-economic recovery in the wake of recent crises such as
The most critical question for climate research is no longer about the problem, but about how to facilitate the transformative changes necessary to avoid catastrophic climate-induced change. Addressing this question, however, will require massive upscaling of research that can rapidly enhance learning about transformations. Ten essentials for guiding action-oriented transformation and energy resea
Considerable efforts by leading experts and funds from around the world are put into restructuring the West Bank justice and security sector (JSS). This is an effort done in a highly contested environment, with an ongoing Israeli occupation and weak local trust in the Palestine Authority (PA). This article analyzes the understandings by local Palestinian non-government organizations and internatio
This chapter explores the French approach to legislative justification in the context of environmental and climate crises. While constitutional law in France recognizes an obligation to rationalize legislation, the enforcement of this duty remains weak and largely procedural. Scientific evidence—though increasingly central to democratic legitimacy—plays a limited role in constitutional review. Ins
The Tajik health system is characterized by improving health outcomes over the last 20 years, but also major inefficiencies in health care delivery and large difficulties for people to access affordable essential health care. The benefits package (BP) is a key tool for prioritizing state budget allocations toward health interventions that most effectively enhance health system performance. This ar
Abstract – Introduction: Peripheral intravenous catheterization is commonly required in sick neonates but remains challenging due to small vessels, leading to multiple attempts and complications. This review evaluated the benefits and harms of device-assisted techniques versus standard technique. Methods: We searched MEDLINE, Embase, CENTRAL, Cochrane Reviews, WHO ICTRP, and ClinicalTrials.gov (Oc
A key critique of urban planning in postcolonial contexts is the persistence of Western/Eurocentric approaches that disregard the spatial production of Black and Indigenous populations as legitimate. In Brazil, despite shifts from authoritarian to democratic governments, racialised territories have consistently been subjected to state intervention. While policies have evolved—from deregulation and
Background: Acute appendicitis is one of the most common causes of acute abdominal pain. Differences in the management of this large group of patients has important consequences for the patients and the healthcare system. Controversies regarding the understanding of the natural course of the disease, the utility of new diagnostic methods, and alternative treatments have lead to large variations in
Efforts to reduce greenhouse gas emissions, globalized markets with intense competition, and generally rising transportation costs emphasize the importance of achieving economically and environmentally sustainable distribution systems. Many international organizations predict that if no new measures are implemented, global carbon dioxide emissions from freight transport will increase to even highe
Atrial fibrillation (AF) is the most common sustained cardiac arrhythmia and is associated with increased risk of stroke, heart failure, and mortality. One of the systems which AF is influenced by is the autonomic nervous system (ANS), which regulates involuntary functions such as heart rate. Environmental stressors, such as air pollution, may also affect these physiological systems and contribute
