Filetype
The protein gC1qR (globular C1q receptor), also named p33, was originally identified as a binding partner of the globular heads of C1q in the complement system. gC1qR/p33 is abundantly expressed in many cell types, but the functional importance of this protein is not completely understood. Here, we investigate the impact of gC1qR/p33 on the production and function of the pathophysiologically impor
Background: Long-term use of opioid analgesics (OA) for chronic pain may result in opioid use disorder (OUD). This is associated with adverse outcomes for individuals, families and society. Treatment needs of people with OUD related to chronic pain are different compared to dependence related to use, and also injection, of illicit opioids. In Nordic countries, day-to-day practical advice to assist
Planning and execution of large infrastructure projects benefit from detailed mapping of the subsurface through geophysical methods. However applying geophysical methods in an urban environment requires careful preparation to ensure success in areas where source of noise and present infrastructure may compromise the results. We present and discuss the results of a seismic investigation conducted i
Previous studies have identified implementation problems connected to sustainable mobility. These difficulties raise the question of which strategies can be successfully pursued to break path dependencies in urban policy making. This article is focused on corporate mobility management as one specific example of sustainable mobility initiatives, and analyses the formation and implementation of a tr
Partially premixed combustion with low octane fuel aims to reduce NOx and soot emission simultaneously without fuel consumption penalty. Cylinder pressure based combustion phase control is an essential technology for partially premixed combustion. A novel closed-loop combustion phase control strategy for multiple combustion modes is proposed in the current study. The combustion modes are classifie
The production of commodities by energy-intensive industry is responsible for 1/3 of annual global greenhouse gas (GHG) emissions. The climate goal of the Paris Agreement, to hold the increase in the global average temperature to well below 2 °C above pre-industrial levels while pursuing efforts to limit the temperature increase to 1.5 °C, requires global GHG emissions reach net-zero and probably
Under en vetenskaplig expedition med det tyska forskningsfartyget R/V Maria Sibylla Merian till Disko Bugt, på västra Grönland, så provtogs under sommaren 2007 ett antal marina sedimentborrkärnor. Borrkärnan med beteckningen 343340-6-1 undersöktes inom ramarna för denna studie med miljömagnetiska metoder. Syftet med undersökningen har varit att kartlägga variationer i de mineralogiska egenskapernaAn 11 m long marine sediment core was collected during a June-July 2007 scientific cruise with the German research vessel R/V Maria Sibylla Merian to the area of Disko Bugt, western Greenland. The core, designated 343340-6-1, was examined using environmental magnetic methods and X-ray fluorescence. The study contributes to a larger project designed to map the variability in sediment source and tra
Persistent physical symptoms (PPS) are common, disabling, and associated with high health care use, yet effective and scalable psychological treatments remain limited. Internet-administrated self-help programs may improve access to care. Asynchronous Internet-administered Emotional Awareness and Expression Therapy (I-EAET) with therapist guidance has been shown to reduce somatic symptoms in PPS, b
Considering the unstable condition of water resources in Iran and many other countries in arid and semi-arid regions, groundwater studies are very important. Therefore, the aim of this study is to model groundwater potential by qanat locations as indicators and ten advanced and soft computing models applied to the Beheshtabad Watershed, Iran. Qanat is a man-made underground construction which gath
PURPOSE: To respond to the psychological needs of adolescent and young adult (AYA) cancer survivors, we developed and evaluated a theoretically grounded online intervention to teach adaptive coping skills to promote resilience in early survivorship: 'Recapture Life'. This qualitative study aimed to evaluate the process of implementing Recapture Life into community organisations, after having been
The purpose of this study was to understand the influence of mothers’ satisfaction with health care on health seeking behaviour for children under-five. With a qualitative approach, this study used focus group discussions and one-on-one interviews to collect data from thirty seven (37) respondents but the focus was on twenty (27) mothers with children under-five in Okwampa, a small rural community
Today’s global competition forces manufacturing companies to re-evaluate their existing processes, technologies, manufactured parts and services in order to focus on strategic activities. The question whether to make or to buy goods or services represents a problem faced by many companies when deciding between keeping technologies/processes in-house or purchasing them from an outside supplier. In
Background: A major challenge of today is to protect the marine ecosystem from a total collapse. Overfishing, illegal, unregulated and unreported fishing, climate change in the sea, coral bleaching, ocean acidification, marine pollution impacts of coastal development, exotic and invasive species and last but not least all the cumulative impacts, are just some of the factors degrading our marine en
Introduction: Access to healthcare is a critical determinant of health and central to Swedish public health policy. Sweden, like many other countries has seen a rise in precarious employment and there has been substantial research into the negative health effects associated with it. In accordance with vertical equality in health care, people exposed to precarious employment should consequently hav
Multiple studies have demonstrated that cancer cells with microsatellite instability (MSI) are intolerant to loss of the Werner syndrome helicase (WRN), whereas microsatellite-stable (MSS) cancer cells are not. Therefore, WRN represents a promising new synthetic lethal target for developing drugs to treat cancers with MSI. Given the uncertainty of how effective inhibitors of WRN activity will prov
Introduction: Obesity is a chronic, progressive, and recurring disease that contributes significantly to multimorbidity across Europe. Despite the publication of numerous clinical practice guidelines (CPGs) for obesity, many chronic disease guidelines for obesity related diseases such as diabetes, MASLD, heart disease, obstructive sleep apnea do not integrate contemporary understandings of obesity
