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Objective: Systemic sclerosis (SSc) and rheumatoid arthritis (RA) are autoimmune diseases that have similar clinical and immunologic characteristics. To date, several shared SSc–RA genetic loci have been identified independently. The aim of the current study was to systematically search for new common SSc–RA loci through an interdisease meta–genome-wide association (meta-GWAS) strategy. Methods: T
Men with a low prostate-specific antigen (PSA) level (<1 ng/ml) in midlife may extend the rescreening interval (if aged 40–59 yr) or forgo future PSA screening (if aged >60 yr) owing to their low risk of aggressive prostate cancer (PCa). However, there is a subset of men who develop lethal PCa despite low baseline PSA. We investigated how a PCa polygenic risk score (PRS) in addition to baseline PS
Can a climate-triggered export of old contaminants from the soil alter the lead (Pb) contaminant burden of subarctic lakes? To address this question, we reconstructed the pollution history of three high latitude lakes situated in a region where a recent climatic shift has occurred. Dated sediment records were used as archives of past Pb inputs to the lakes, where the difference in the (206)Pb/(207
The purpose of this study is to compare the value of statistical life (VSL) estimates for traffic, drowning, and fire accidents. Using a choice experiment in a mail survey of 5,000 Swedish respondents we estimated the willingness to pay for risk reductions in the three accidents. In the experiment respondents were asked a series of questions, whether they would choose risk reducing investments whe
A pollen diagram from a small peat bog on the island of Tristan da Cunha in the central South Atlantic (37 degrees 05'S, 12 degrees 17'W) is presented. The pollen diagram contains data from both introduced and native plant taxa. The earliest pollen grains from introduced Plantago lanceolata are dated to around AD 1570, and probably represent unintentional introductions of weeds by the earliest Por
Permafrost in peatlands of subarctic Sweden is presently thawing at accelerated rates, which raises questions about the destiny of stored carbon and nutrients and impacts on adjacent freshwater ecosystems. In this study we use peat and lake sediment records from the Stordalen palsa mire in northern Sweden to address the late Holocene (5,000 cal BP-present) development of the mire as well as relate
Dendrochronological analysis was applied to subfossil remains of Scots pine (Pinus sylvestris L.) buried in a South Swedish peat deposit. In combination with peat stratigraphy, this approach was explored for its potential to provide information on the local hydrological and depositional history at the site, forming the basis for a regional palaeohydrological analysis. A 726-year ring-width chronol
Many of Sweden’s red listed species are found in the agricultural landscape. Small biotopes (e.g. field margins and field islets) are important for the maintenance of biodiversity in agricultural landscapes, and agri-environmental support is paid to farmers who keep them open. However, a proper evaluation of the biodiversity-gains from this type of management is lacking. We examined the predicted
An important constraint on the reliability of cosmogenic nuclide exposure dating is the rigorous determination of production rates. We present a new dataset for Be-10 production rate calibration from Mount Billingen, southern Sweden, the site of the final drainage of the Baltic Ice Lake, an event dated to 11,620 +/- 100 cal yr BP. Five samples of flood-scoured bedrock surfaces (58.5 degrees N, 13.
Comparison between growth variability, based on ring-width (RW) analysis, and moisture-sensitive signals in tree-ring carbon and oxygen stable-isotope composition provides increased understanding of how climate and hydrology influenced bog pines (Pinus sylvestris L) at two sites in southern Sweden during the mid- and late Holocene. Tree-ring sequences from two subfossil trees collected at raised b
The countries of the European Union are in an ongoing phase of integration. The influences on individual states domestic structures are unquestionable and the governing prerequisites have changed significantly. Poland, a relatively new member state is in the middle of the process and so this study analyses the effects of Europeanization on polishes domestic structures. The study examines four pub-
With rapid urbanization and an increasing share of anthropogenic greenhouse gas emissions from cities, low-carbon urban transformations are critical for mitigating climate change. Local climate networks have been recognized for their potential to govern such activities. However, less is known about how such networks are implemented and managed as well as their capacity to accelerate transformative
It is a common experience among children to witness domestic violence, but how much does it affect the child later on in life? The purpose of this paper is to present what happens to the child mentally and physically when domestic violence against women results in the death of a mother and the imprisonment of a father. The paper also presents ways to minimize the impact the event has on the child.
The number of refugees across the world is increasing and consequently also the preassure at the external borders of the EU. The purpose of this essay is to evaluate the actual refugee policy of the European Union in relation to the Universal Declaration of Human Rights, which is ratified by all member states, as well as the Charter of Fundamental Rights of the European Union. Human rights organis
This paper describes how four teachers from the same school translate democracy from the curriculum. The interviews describes how the teachers work with the curriculum and what kind of difficulties they confront in the meeting with the students and other teachers. Through qualitative interviews of these teachers, have allowed us to read into their reflections as they explain their reality of the m
This thesis examines the role of public servants in official development assistance (ODA), a form of foreign aid administered by states. While research on foreign aid highlights its potential to improve living conditions, it also reveals issues of ineffectiveness and overconfidence within the aid sector. Moreover, certain forms of foreign aid continued and can still continue to perpetuate colonial
Abstract in UndeterminedPurpose – The purpose of this paper is to give an overview of the concept of HRCA – human resource costing and accounting – and to encourage debate in this research area. The knowledge dimensions or research areas of HRCA could be described by using a simple model or classification scheme. The model could be seen as a way to describe the links between accounting and financi
