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Background Early-onset depression contributes significantly to long-term disability and suicide, making high-quality healthcare for young people with depression a critical concern. Medical record review (MRR) is widely used to assess healthcare quality. However, its application to depression care for children and adolescents appears underexplored, with no consensus on conceptualising or measuring
Making money at the expense of planet Earth is an unfortunate practice that has strengthened over the years with dire consequences for the environment and human rights.Although several initiatives have been taken at different levels to counter this phenomenon, environmentally unfriendly activities continue to be among the most serious crimes and human rights violations, while the need to prevent t
A prerequisite to applying 10Be in natural archives for solar and geomagnetic reconstructions is to know how 10Be deposition reflects atmospheric production changes. However, this relationship remains debated. To address this, we use two state-of-the-art global models GEOS-Chem and ECHAM6.3-HAM2.3 with the latest beryllium production model. During solar modulation, both models suggest that 10Be de
BACKGROUND: Cutaneous T-cell lymphoma (CTCL) is a rare group of lymphomas that primarily affects the skin. Mycosis fungoides (MF) is the most common form of CTCL and Sézary syndrome (SS) is more infrequent. Early stages (IA-IIA) have a favorable prognosis, while advanced stages (IIB-IVB) have a worse prognosis. Around 25% of patients with early stages of the disease will progress to advanced stage
Popular Abstract in Swedish Tänk dig ett system som kan bestämma hur olika typer av luftpartiklar skadar oss när dom hamnar i våra lungor. Ett system som dessutom kan skapa luftpartiklar för dessa studier vid behov och med väl uppmätta egenskaper. Denna avhandling handlar om just ett sådant system och experiment som är viktiga för att förstå om och hur det fungerar. Systemet kallas i denna avhandlExposure to nano-sized and nanostructured aerosol particles with tailored properties are likely to increase in society. Occupational exposure to various kinds of nanostructured aerosol particles such as soot and metal aggregates already exists. To understand the adverse human health effects of these particles, there is a need for systems that can Generate a stable output of aerosol particles, Char
Using delayed-coincidence techniques we have measured the natural radiative lifetimes of several S and D states in Rb and Cs. The states were excited by a pulsed dye laser from the first P state, populated using an rf discharge lamp.
Fire models are used increasingly for fire safety assessment in nuclear power plants. Examples of these fire models are CFD models and zone models. When using these models it is important that they are sufficiently verified and validated. In Sweden the majority of fire safety consultants are using FDS, developed by NIST. The verification and validation of this package is intensively done for a num
This study investigates the effects of Age of Onset of Acquisition (AOA) and the quality and quantity of input on the longitudinal development of gender in the acquisition of French by simultaneous (2L1) and successive bilinguals (cL2). Three exponents of French gender are studied: the discovery of the abstract GENDER feature, gender assignment and gender concord. The findings show that the amount
Protein S is a vitamin K dependent plasma protein and a cofactor to activated protein C, a serine protease that regulates blood coagulation. The haploid genome contains two protein S genes (alpha and beta) with the protein S alpha-gene corresponding to the cloned cDNA. We have now isolated and mapped overlapping genomic clones that cover an area of 50 kilobases of the protein S alpha-gene which co
Substance P (SP) and calcitonin gene-related peptide (CGRP) have both been considered potential drug candidates in migraine therapy. In recent years, CGRP receptor inhibition has been established as an effective treatment, in particular as a prophylactic for chronic migraine. Curiously, inhibition of neurokinin receptor 1 (NK1R) failed to alleviate acute migraine attacks in clinical trials, and th
A sensitive and rapid enzyme-linked immunosorbent assay for simultaneous quantitation of free and IgA-complexed human protein HC was developed with monoclonal murine antibodies. The total amount of protein HC (free plus IgA-complexed) was measured by a competitive procedure while the protein HC-IgA complex was quantitated by a sandwich enzyme immunoassay. The amount of free protein HC was then obt
Recent studies have indicated that serum and plasma cystatin C are better markers for glomerular filtration rate (GFR) than serum creatinine, ubiquitously used for this purpose. To fully exploit the value of serum and plasma cystatin C as GFR markers, reliable age and sex-correlated reference intervals are required. The present study comprised cystatin C determinations in plasma and sera from 259
This paper uses the notion of material affordances to show that a focus on how people engage with materials helps understanding how organizations transit toward sustainability. Material affordances refer to the enablements and constraints afforded by materials to someone engaging with an environment for a particular purpose. Based on a qualitative study of a company's efforts at becoming circular,
Background: Joint destruction in rheumatoid arthritis (RA) is usually evaluated by radiographs of both hands and feet, while the inflammatory status mostly is evaluated by DAS28 which, however, does not include the feet. Objectives: To investigate the distribution of erosions in hands and feet in early RA over 8 years and its potential clinical implications. Furthermore, the group of patients neve
Introduction: The aim of this study was to evaluate the construct validity, floor and ceiling effects, data completeness and magnitude of change over time for the eight-item patient questionnaire (HQ-8) in the Swedish Healthcare Quality Registry for hand surgery (HAKIR). Methods: Construct validity was investigated through predefined hypotheses and correlation statistics between the single items i
Objective: The authors sought to clarify the role of rearing environment in the etiology of major depression. Methods: Defining high risk as having at least one biological parent with major depression, the authors identified a Swedish National Sample of 666 high-risk full sibships and 2,596 high-risk half sibships containing at least one homereared and one adopted-away sibling. Major depression wa
