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Background: Genetic variants within nearly 1000 loci are known to contribute to modulation of blood lipid levels. However, the biological pathways underlying these associations are frequently unknown, limiting understanding of these findings and hindering downstream translational efforts such as drug target discovery. Results: To expand our understanding of the underlying biological pathways and m

The application of multiple omics technologies in biomedical cohorts has the potential to reveal patient-level disease characteristics and individualized response to treatment. However, the scale and heterogeneous nature of multi-modal data makes integration and inference a non-trivial task. We developed a deep-learning-based framework, multi-omics variational autoencoders (MOVE), to integrate suc

The Nordic countries offer an ideal case study of the COVID-19 pandemic due to their comparability, high data quality, and variable mitigations. We investigated the age- and sex-specific mortality patterns during 2020–2021 for the five Nordic countries and analysed the total age- and sex-adjusted excess deaths, ratios of actual to expected death rates, and age-standardized excess death estimates.

A major challenge of genome-wide association studies (GWASs) is to translate phenotypic associations into biological insights. Here, we integrate a large GWAS on blood lipids involving 1.6 million individuals from five ancestries with a wide array of functional genomic datasets to discover regulatory mechanisms underlying lipid associations. We first prioritize lipid-associated genes with expressi

This chapter outlines how the history of health care in Syria has shaped the way in which wartime health care has been delivered and controlled. The chapter analyzes the claim by humanitarian organizations to a form of neutrality in the Syrian war, which was ultimately incompatible with the way the Syrian state and the opposition saw aid delivery as part of the battle for statehood. It also mentio

Pure hydrocarbons with shape and conjugation properties that can be switched by external stimuli is an intriguing prospect in the design of new responsive materials and single-molecule electronics. Here, we develop an oligomeric [8]annulene-based material that combines a remarkably efficient topological switching upon redox changes with structural simplicity, stability, and straightforward synthes

α-Synuclein (α-syn) is an intrinsically disordered protein with a highly asymmetric charge distribution, whose aggregation is linked to Parkinson’s disease. The effect of ionic strength was investigated at mildly acidic pH (5.5) in the presence of catalytic surfaces in the form of α-syn seeds or anionic lipid vesicles using thioflavin T fluorescence measurements. Similar trends were observed with

Syftet med uppsatsen är att undersöka om åsikterna skiljer sig åt beroende på vilken geografisk region respondenten härstammar ifrån samt att undersöka om åsikterna skiljer sig åt mellan intressegrupperna. För att bearbeta materialet har en kvantitativ innehållsanalys gjorts av inkomna kommentarsbrev till IASB:s exposure draft 2013/9 för IFRS for SMEs som, utöver förslagen, innehöll åtta direkta

Under de senaste 10 åren har cirka en miljon människor sökt asyl i Sverige varav hela 163 000 enbart under 2015 när den stora flyktingvågen tog fart i världen. Detta satte stor press på Sveriges hantering av flyktingar och framförallt kommunernas bostadsförsörjningsansvar. Den 1 mars 2016 införde regeringen beslutet att kommunerna är skyldiga att ta emot ett visst antal nyanlända i syfte att ge deDuring the last 10 years approximately one million people have applied for asylum in Sweden and 163 000 only during the big stream of immigrants in 2015. This put a huge pressure on the Swedish management of immigrants and the housing for this group of people. The 1st of March 2016 the Swedish Government introduced a law where the Swedish municipalities are obligated to receive a certain number of

Purpose: The purpose of this research was to investigate how outdoor textile brands align their brand bdentity with their management actions and communication to become more circular. It was as a consequence explored how communication strategies of outdoor brands align with their management decision and how management actions push the transition of a brand towards more circularity. Methodology: Th

The principal rule of the common market is that goods and services are able to move freely across the borders of Member States. State monopolies in control of supply and demand are, therefore, only under exceptional circumstances compatible with the conditions of the common market. The compatibility of Swedish State monopolies with EC law is a controversial matter. The case-law of the ECJ lets us

The interactions between aerosols and clouds are still one of the largest sources of uncertainty in quantifying anthropogenic radiative forcing. To reduce this uncertainty, we must first determine the baseline natural aerosol loading for different environments. In the pristine and hardly accessible polar regions, the exact nature of local aerosol sources remains poorly understood. It is unclear ho

Background and Aims. While the rationale for coronavirus disease 2019 (COVID-19) vaccination is to reduce complications and overall mortality, some cardiovascular complications from the vaccine itself have been demonstrated. Myocarditis and pericarditis are recognized as rare acute adverse events after mRNA vaccines in young males, while evidence regarding other cardiovascular events remains limit

INES PhD student NEWSLETTER Issue 7 October | 2021 The INES PhD student Newsletter appears monthly and highlights news and events pertaining to INES PhD students. Please contact mayra.rulli@nateko.lu.se with any comments, suggestions or contributions. WEDNESDAY PHD FIKA AND SEMINAR SERIES Every Wednesday at 15:00 our INES PhD community meets (at INES kitchen from November) to chat, give updates, c

https://www.nateko.lu.se/sites/nateko.lu.se/files/2021-12/PhD_Newsletter_October2021.pdf - 2026-05-25

Human Rights Research and Analysis Archives - The Raoul Wallenberg Institute of Human Rights and Humanitarian Law Skip to content Search for: Search Button Home About Us Who We Are Our History About Raoul Wallenberg Our Theory of Change Staff Opportunities Annual Reports Whistleblower Our work What we do Multi-Disciplinary Research Higher Education Strategic Advice and Analysis Outreach Evaluation

https://rwi.lu.se/news-categories/human-rights-research-and-analysis/ - 2026-05-23