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The immune processes associated with atherogenesis have received considerable attention during recent years. IgG FcRs (FcgammaR) are involved in activating the immune system and in maintaining peripheral tolerance. However, the role of the inhibitory IgG receptor FcgammaRIIB in atherosclerosis has not been defined. Bone marrow cells from FcgammaRIIB-deficient mice and C57BL/6 control mice were tra

Measurements are presented of inclusive charm and beauty cross sections in e(+)p collisions at HERA for values of photon virtuality 12 <= Q(2) = 60 GeV2 and of the Bjorken scaling variable 0.0002 <= x <= 0.005. The fractions of events containing charm and beauty quarks are determined using a method based on the impact parameter, in the transverse plane, of tracks to the primary vertex, as measured

Protein kinase C (PKC) plays a prominent role in immune signaling, and the paradigms for isoform selective signaling are beginning to be elucidated. Real-time microscopy was combined with molecular and biochemical approaches to demonstrate a role for PKC-epsilon in Fcgamma receptor (FcgammaR)-dependent phagocytosis. RAW 264.7 macrophages were transfected with GFP-conjugated PKC isoforms, and GFP m

OBJECTIVE: To investigate the possible role of FCGR2A 519A>G and FCGR3A 559A>C functional polymorphisms in the genetic predisposition to susceptibility to systemic sclerosis (SSc) or clinical phenotype. METHODS: A total of 1566 patients with SSc and 2271 geographically matched controls were included in our study. We analyzed the genotype and allele frequencies of the FCGR2A 519A>G and FCGR3A 559A>

Immunoglobulin G (IgG) glycosylation modulates antibody activity and represents a major source of heterogeneity within antibody preparations. Depending on their glycosylation pattern, individual IgG glycovariants present in recombinant antibody preparations may trigger effects ranging from enhanced pro-inflammatory activity to increased anti-inflammatory activity. In contrast, reduction of IgG gly

In a previous study we presented data indicating that the expanded population of CD4(-)CD8(-) (DN) alphabeta T cells in TCRalpha-chain-transgenic mice was partially if not entirely derived from gammadelta T cell lineage cells. The development of both gammadelta T cells and DN alphabeta T cells is poorly understood; therefore, we thought it would be important to identify the immediate precursors of

Current hemophilia B treatment guidelines recommend routine prophylaxis with factor IX (FIX) replacement products, tailored to maintain plasma activity at levels that will prevent bleeds. However, plasma FIX activity may not be the primary determinant or best indicator of hemostatic efficacy due to its extravascular distribution. FIX replacement therapy has evolved to include extended half-life (E

The course explores and explains the historical processes of rapid industrialisation and socio-economic modernisation in Pacific Asia. First, fundamental factors and forces behind the rise of Asia’s first industrial nation, Japan, are analysed. Japan is also contrasted against the early failures of modernisation in Imperial China. Secondly, explanations are provided for the emergence of Taiwan,

Kursens behandlar: Funktioner av flera variabler: grundläggande topologi i R3, kontinuitet Differentialkalkyl för funktioner av flera variabler: partiella derivator,differentierbarhet, kedjeregeln, gradient och riktningsderivata, extremvärden,tillämpningar av differentialkalkyl Integralkalkyl för funktioner av flera variabler: multipelintegraler,variabelsubstitution, tillämpningar OrdinäThe course treats: Functions of several variables: basic topology in R3, continuity, Differential calculus of functions of several variables: partial derivatives,differentiability, the chain rule, gradient and directional derivatives, extreme values, applications of differential calculus, Integral calculus of functions of several variables: multiple integrals, variable substitution, applic

This course deals with current issues relating to aging societies. An increasing share of elderly has for a long time characterized Sweden and other developed countries. The course deals with questions like: If this did not constitute a challenge before, why is it the case today? Is the welfare state, as we today know it compatible with an aging society? How can we finance the welfare of

Kursen fokuserar på att öka medvetandet om olika metoder och förhållningssätt kopplat till framförandet av musik där musikern ges stort utrymme att fylla ut musiken med hjälp av egna musikaliska idéer och initiativ. Vidare syftar kursen till att ge kursdeltagarna praktisk erfarenhet genom användandet av dessa metoder och förhållningssätt i samspel med andra. Undervisning sker i grupp. Prelim

Grunderna för maskininlärning samt de matematiska och beräkningsmässiga förkunskaperna för deep learning. Feed-forward artificiella neuronnät, convolutional artificiella neuronnät och de återkommande kopplingarna till feed-forward artificiella neuronnät. En kort historik över artificiell intelligens och artificiella neuronnät, samt genomgång av intressanta olösta forskningsproblem inom deep The fundamentals of machine learning, and the mathematical and computational prerequisites for deep learning Feed-forward neural networks, convolutional neural networks, and the recurrent connections to a feed-forward neural network A brief history of artificial intelligence and neural networks, and reviews interesting open research problems in deep learning and connectionism. The course

Vill du följa upp dina studier inom skandinavisk och europisk film och television med ett avslutande fördjupningsprojekt? I denna delkurs får du möjlighet att fördjupa dig i ett eget projekt som integrerar teman från de tidigare delkurserna om skandinavisk och europeisk film och tv. Kursen fokuserar på det egna arbetet i anslutning till ett eget tema och frågeställning samt en eller flera filmer Would you like to follow up your studies in Scandinavian and European film and television with a final in-depth project? In this module, you will have the opportunity to immerse yourself in a project of your own that integrates themes from the previous modules on Scandinavian and European film and television. The course focuses on your own work in connection with your own theme and question,