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Here, we describe the generation of an induced pluripotent stem cell (iPSC) line, from a male patient diagnosed with Parkinson's disease (PD). The patient carries a heterozygous variation p.A53T in the SNCA gene. Skin fibroblasts were reprogrammed using the non-integrating Sendai virus technology to deliver OCT3/4, SOX2, c-MYC and KLF4 factors. The generated iPSC line (CSC-32) preserved the mutati
This study delves into the landscape of health applications within online markets. These applications, offering health-related functionalities, have become integral to the lives of European citizens. The transformation of healthcare delivery, accelerated by the pace of modern life and accentuated by the COVID-19 pandemic, has elevated health applications from conveniences to essential tools capabl
Background: Cortical contusions are common in moderate-severe traumatic brain injury (TBI). Cortical contusions often expand, potentially causing neuro-worsening several hours to days post-trauma. While contusion expansion (CE) may affect outcome, potential clinical and radiological markers that can predict CE have been insufficiently explored. In the present single-center retrospective observatio
Haematopoietic stem cell (HSC) self-renewal is a process that is essential for the development and homeostasis of the blood system. Self-renewal expansion divisions, which create two daughter HSCs from a single parent HSC, can be harnessed to create large numbers of HSCs for a wide range of cell and gene therapies, but the same process is also a driver of the abnormal expansion of HSCs in diseases
We investigated the role of cultural experience in the search advantage for happy faces. European British participants living in the UK, Asian Japanese participants living in Japan, and Asian Japanese participants living in the UK, were required to search for a happy or an angry face target against a background of neutral facial expressions, using Asian Japanese and European American faces. Result
Legal persons have traditionally been understood as entities with legal rights and/or duties. This traditional concept of legal personhood has been challenged during the last decades: In legal practice through the global development in law where previous legal non-persons such as different non-human natural entities, non-human animals, fetuses and artificial intelligences have been ascribed, or be
Structural Health Monitoring (SHM) provides real-time information about structural damage and its evolution over time, which supports decision-makers in managing structural integrity. However, traditional SHM systems, such as vibration-based systems with accelerometers, require laborious installation and maintenance of instrumentation, including sensors, cables, and acquisition systems directly in
Neutrophil gelatinase-associated lipocalin (NGAL) is a novel kidney injury and inflammation biomarker. We investigated whether NGAL could be used to predict continuous renal replacement therapy (CRRT) and mortality in critical coronavirus disease 2019 (COVID-19). This prospective multicenter cohort study included adult COVID-19 patients in six intensive care units (ICUs) in Sweden between May 11,
Hydropower is a renewable, reliable, and highly predictable source of energy. It has been used for centuries. The tariff of energy generation is divided into two parts: fixed charges and variable charges. Fixed charges are based on the availability of machinery (i.e., plant availability factor) and variable charges are based on the actual energy generation. The energy generation targets are decide
Children with generalized anxiety disorder (GAD) are often described by their parents or teachers as "little adults, " in part because of the seemingly adult-like themes that populate their child's worries; for example, the health of family members or family finances and concerns about performance. Younger children may experience more vague worries of "something" bad happening to themselves, famil
To study how mechanical factors influence the spread of cancer and the surrounding extracellular matrix (ECM), it is crucial that cancer cell populations be sorted without labels in relevant subpopulations with respect to mechanical properties. It is also important to confine subpopulations for long-term observation to track changes, in inherent properties of the subpopulations, and on the influen
We show acoustic separation of 7.8 µm from 5 µm fluorescent polystyrene particles at an unprecedented sample flowrate of almost 1000 µL/min.
For older people using long-term care services, the conditions of their life-space may be critical. The relationships between the physical housing environment and aspects of health were examined among older people in Japan (aged 65+ years, N = 1,928) by multivariable logistic regression analysis, adjusting for sociodemographic characteristics. Lack of safety, low access to emergency assistance, lo
Urbanization has resulted in a gigantism of urban complexes and in many environmental and social problems. The situation on the surface and the principles of sustainable development compel urban planners to utilize the urban underground space, which for centuries has been almost exclusively the application field of mining. More often than not spatial planning in urban areas allocates various land-
This article aims at describing a logistic approach for prolonged resuscitation efforts in the cath-lab using mechanical chest compressions (MCC) during simultaneous percutaneous coronary intervention (PCI).
Historical review of 100 years of relationship between Christians and Muslims in East Africa, with particular reference to challenges of the Christian theological education in relation to Islam.
We present a non-contact platelet functional analysis platform based on acoustic trapping of platelet clusters and activation monitoring using impedance spectroscopy. The system was characterized using polystyrene particles and human platelets. The system was also capable of transferring platelets from plasma into a controlled buffer. Trapped platelets were activated using 20 and 40 μM TRAP and th
Flera platser utmed den skånska kusten har idag problem med stranderosion som innebär att havet äter sig inåt land så att stränder och kustlandskap försvinner. När havet stiger förväntas stranderosionen att öka och även kust sträckor som idag inte har problem kan komma att drabbas. Då kustlinjen rör sig inåt land hotas bebyggelse, infra struktur och naturområden, samtidigt som översvämningsrisken Beach erosion is expected to increase as the sea level rises during the coming decades. A retreating coastline threat ens infrastructure, settlements, nature habitats, and at the same time increases the flood risk in low-lying areas. On the Swedish south coast, beach erosion is a problem at present likely to increase due to the sea level rise. For main taining the beaches and protecting the hinter
