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RATIONALE AND OBJECTIVES: We wanted to improve determination of the glomerular filtration rate (GFR) with plasma clearance techniques because the alternative-renal clearance techniques-may involve inaccurate urine sampling or risk of urinary tract infection when bladder catheterization becomes necessary. Therefore, we compared the renal and plasma clearances of iohexol and chromium-51-ethylenediam
A general mathematical model for the characterization of the dynamic (kinetically labile) association of supramolecular assemblies in solution is presented. It is an extension of the equal K (EK) model by the stringent use of linear algebra to allow for the simultaneous presence of an unlimited number of different units in the resulting assemblies. It allows for the analysis of highly complex dyna
Introduction Trastuzumab is part of the standard treatment for HER2-positive breast cancer. The aim of this study was to estimate the societal value of trastuzumab administered through subcutaneous (SC) injection compared to intravenous (IV) infusion. Methods Female patients with HER2-positive breast cancer receiving SC or IV trastuzumab were consecutively enrolled from five Swedish oncology clini
Background: Long-term exposure to air pollution has been hypothesized to elevate arterial blood pressure (BP). The existing evidence is scarce and country specific. Objectives: We investigated the cross-sectional association of long-term traffic-related air pollution with BP and prevalent hypertension in European populations. Methods: We analyzed 15 population-based cohorts, participating in the E
Background: Ambient air pollution is suspected to cause lung cancer. We aimed to assess the association between long-term exposure to ambient air pollution and lung cancer incidence in European populations. Methods: This prospective analysis of data obtained by the European Study of Cohorts for Air Pollution Effects used data from 17 cohort studies based in nine European countries. Baseline addres
Background The contribution of modifiable risk factors to the increasing global and regional burden of stroke is unclear, but knowledge about this contribution is crucial for informing stroke prevention strategies. We used data from the Global Burden of Disease Study 2013 (GBD 2013) to estimate the population-attributable fraction (PAF) of stroke-related disability-adjusted life-years (DALYs) asso
Background. Patients use self-care to relieve symptoms of common colds, yet little is known about the prevalence and patterns across Europe. Methods/Design. In a cross-sectional study 27 primary care practices from 14 countries distributed 120 questionnaires to consecutive patients (≥18 years, any reason for consultation). A 27-item questionnaire asked for patients' self-care for their last common
The LHCb experiment, presently under construction at CERN (European Center for Nuclear Research) Large Hadron Collider (LHC), aims at the study of CP violation in the B meson sector. Its key elements will be a Muon detector which allows triggering and muon identification from inclusive b decays. The electronic system of the whole detector is very complex and its Muon detector Experiment Control Sy
A search is presented for a narrow resonance decaying to a pair of Z bosons using data corresponding to 1.02 fb(-1) of integrated luminosity collected by the ATLAS experiment from pp collisions at root s= 7 TeV. Events containing either four charged leptons (llll) or two charged leptons and two jets (lljj) are analyzed and found to be consistent with the Standard Model background expectation. Lowe
Background: ABO genotyping is complicated by the remarkable diversity at the ABO locus. Recombination or gene conversion between common alleles may lead to hybrids resulting in unexpected ABO phenotypes. Furthermore, numerous mutations associated with weak subgroups and nondeletional null alleles should be considered. All known ABO genotyping methods, however, risk incorrect phenotype predictions
Aim: To investigate the effect of general anaesthesia on the TCI-dosage, the depth of anaesthesia and the need for hemodynamic treatment. A comparison between general anaesthesia (GA) alone and general anaesthesia combined with epidural anaesthesia (GA+EDA). Background: There are some uncertainties in the literature whether epidural anaesthesia has any effect on general anaesthesia governed by Ta
The thesis studies the situation within Lund University in relation to the implementation of the European Standards and Guidelines (ESG) developed by The European Association for Quality Assurance in Higher Education (ENQA). The aim of the study is to answer the following research question “How have Lund University implemented the European Standards and Guidelines developed by The European Associa
Nuvarande reglering av säkerhet i lös egendom i Sverige bygger, med undantag för några lagstiftningsåtgärder, på rättspraxis och juridisk doktrin. Även om pantsättning är huvudmetoden för att ställa säkerhet, används i praktiken flera olika typer av säkerhetsrätter då lagstiftaren infört separata registersystem (t.ex. företagshypotek) och då äganderätt i praktiken ofta används som säkerhet (t.ex. Present Swedish law concerning security over movable assets is largely based on case law and legal literature, with some statutory intervention. Although the principal form of security is the possessory pledge, various security devices are used in practice, pursuant to legislative introductions of separate registration systems (e.g. floating charges) and the commercial use of ownership for securit
To stay within our planet’s limits and reach the United Nation’s Sustainable Development Goals, there is an urgent need to rethink our current and dominant systems. This thesis focuses on the food system, in particular, and explores how an overarching turnaround in the way we produce and consume food has the potential to trigger and steer a greater transition towards sustainability. However, this
Swedish camera surveillance legislation has since 1977 contained requirements for permits, a consideration of the involved interests, and a duty to inform the surveilled. This applies to both authorities and citizens alike. The exceptions to these obligations have been few and restrictive. Over the years, surveillance legislation has been modernized to keep up with technological developments and p
Background: Globalization is a phenomenon which has been around since the mid- 19th century, influencing companies to either expand existing markets or entering new markets, to seek new profits. For companies with a global supply chain, the total supply chain cost is a vital factor. It is of high importance to reduce the costs in the supply chain, as lower costs will increase the profit. The case
This paper aims to examine the arguments proposed by the Obama administration regarding a U.S. military intervention in Syria due to the use of chemical weapons by the Syrian regime in 2013. During his presidency, Obama stated that the He draws a ‘red line’ at the use of chemical weapons against civilians, but the threat proved to be empty a year later when thousands of people were killed in a che
The consumption of plastic bags is a global problem that leads to increased concentration of plastic in the world oceans. In 2014, annual consumption of plastic carrier bags amounted to around 100 billion in the EU, which corresponds to an average of about 200 bags per person per year, of which many plastic bags are used only once and/or end up as waste in nature. This thesis is a comparative case
