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Various proteases in the brain contribute to ischemic brain injury. We investigated the involvement of the asparaginyl endopeptidase legumain after experimental stroke. On the basis of gene array studies and in situ hybridizations, we observed an increase of legumain expression in the peri-infarct area of rats after transient occlusion of the middle cerebral artery (MCAO) for 120 mins with a maxim
REPORT TITLE Abbreviations, and Acronym Executive Summary Introduction 1. Research Method ........................................................................................................... 11 2. Data Analysis Method ................................................................................................... 12 Part One: Introduction to the Book “Islamic Emirate and its System” A Gl
https://rwi.lu.se/wp-content/uploads/2024/04/M.A.A-Ramizpoor-RWI-Afghanistan-2023.pdf - 2026-07-05
The compositions of alternative jet fuels can vary radically, and the consequences of these differences are a subject of ongoing investigation. Numerical combustion simulations are vital to this research and require chemical reaction mechanisms that efficiently and accurately capture the chemical pathways of combustion. Here, we present the recently developed Z79 collection of small pathway-centri
Carbon-14 (14C) is an important contributor to the collective effective dose to the public due to releases from nuclear power plants (NPPs). In Sweden, only airborne emissions of 14C from NPPs are currently routinely monitored, and the existing data on waterborne 14C discharges are limited. A recent study of 14C in brown algae (Fucus spp.) in Swedish coastal waters showed higher F14C values collec
Ribbed channel flows play a crucial role in various engineering systems where turbulence enhancement and improved heat transfer are required, such as in turbine blade cooling and combustor wall applications. Numerical simulations have emerged as an essential tool for analyzing the intricate turbulence dynamics and flow separation phenomena, which are fundamental for optimizing the channel performa
OBJECTIVES: To evaluate the long-term benefits of progressive resistance training in chronic stroke. DESIGN: A 4-year follow-up of a randomized controlled trial of progressive resistance training. SUBJECTS: Eighteen women and men (mean age 66 (standard deviation 4) from the original group of 24 post-stroke participants. METHODS: The training group (n = 11) had participated in supervised progres
Permafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permafPermafrost warming has the potential to amplify global climate change, because when frozen sediments thaw it unlocks soil organic carbon. Yet to date, no globally consistent assessment of permafrost temperature change has been compiled. Here we use a global data set of permafrost temperature time series from the Global Terrestrial Network for Permafrost to evaluate temperature change across permaf
Teatern och skådespelaren har i olika sammanhang och under olika historiska epoker betraktats med misstroende och fientlighet. Man kan rent av tala om en historisk tradition av antipatier där teaterscenen och skådespelarens förvandlingskonst har misstänkliggjorts i egenskap av moraliska instanser. I denna tradition möts filosofer och religiösa moralister, men också teaterpraktiker med olika agendo
Significance Our results demonstrate the existence of early cellular pathways and network alterations in oligodendrocytes in the alpha-synucleinopathies Parkinson's disease and multiple system atrophy. They further reveal the involvement of an immune component triggered by alpha-synuclein protein, as well as a connection between (epi)genetic changes and immune reactivity in multiple system atrophy
This study assesses the potential benefit of Blue-Green Solutions (BGS), green rooftops, rain gardens, permeable pavements, and bioswales, in Lisbon, Portugal. These proposed mitigation measures are applied using TFM-DYN (Nilsson et al., 2021) to simulate potential fluvial flooding distributions from a 10- and 50-year rain event.Water depth of over 30 centimeters can cause damage to infrastructure
Agricultural intensification at field and landscape scales, including increased use of agrochemicals and loss of semi-natural habitats, is a major driver of insect declines and other community changes. Efforts to understand and mitigate these effects have traditionally focused on ecological responses. At the same time, adaptations to pesticide use and habitat fragmentation in both insects and flow
The TFM-DYN model represents a significant advancement from static flow accumulation estimations into dynamic hydrological modeling (Nilsson et al., 2021). It incorporates variable precipitation in time and space as input together with high-resolution topography and includes functions for friction and infiltration to produce results such as water depths, flow velocity, inundated areas, flow pathwa
Lean, premixed, swirl-stabilized flames are widely used in modern Dry Low Emissions gas turbine combustors; however, the turbulent combustion process under those conditions is known to be extremely sensitive and prone to instabilities. Numerical simulations can be a valuable tool in predicting the effects of alternative fuels; however, the sensitivity of the results to different models ought to be
BACKGROUND: Autoantibodies are common in glomerulonephritis, but the clinical benefit of rapid elimination is not determined, even in anti-glomerular basement membrane (GBM) disease. Even less is known about the importance of autoantibody characteristics, including epitope specificity and IgG subclass distribution. By utilizing samples from the GOOD-IDES-01 trial, where imlifidase, cleaving all Ig
During epileptic seizures, neuronal network activity is hyper synchronized whereby GABAergic parvalbumin-interneurons may have a key role. Previous studies have mostly utilized 4-aminopyridine to induce epileptiform discharges in brain slices from healthy animals. However, it is not clear if the seizure-triggering ability of parvalbumin-interneurons also holds true without the use of external conv
Drought-induced canopy browning and recovery dynamics threaten ecosystem stability worldwide, with Australia serving as a representative case. This study examined the 2019–2020 drought and subsequent recovery in Eucalyptus forests across two bioregions of the Australian state of New South Wales (NSW): the North Coast and South Eastern Highlands. Canopy browning and recovery were quantified using a
Miljömålsberedningens (MMB) betänkande kommer vid en viktig tid, när tiden blir alltmer knapp för att sträva efter beslutade nationella och internationella mål om klimat och biologisk mångfald. De närmaste åren är på många sätt kritiska för att dels begränsa klimatpåverkan, dels värna om natur och biologisk mångfald i linje med vetenskapen och beslutade ambitionsnivåer. Det är mycket viktigt med å
