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Background: European treatment guidelines recommend prasugrel over ticagrelor for treating patients with non–ST-elevation acute coronary syndrome (ACS), prompting several Swedish administrative regions to transition from ticagrelor to prasugrel as the preferred treatment for patients with ACS. We aim to systematically evaluate this transition to determine the relative efficacy of prasugrel versus
Multiple trade-offs likely occur between pesticide use, pollinators and yield (via crop flowers) in pollinator-dependent, mass-flowering crops (MFCs), causing potential conflict between conservation and agronomic goals. To date, no studies have looked at both outcomes within the same system, meaning win-win solutions for pollinators and yield can only be inferred. Here, we outline a new framework
The daily transition between day and night, known as the diel cycle, is characterised by significant shifts in environmental conditions and biological activity, both of which can affect crucial ecosystem functions like pollination. Despite over six decades of research into whether pollination varies between day and night, consensus remains elusive. We compiled the evidence of diel pollination from
Anthropogenic nitrogen (N) deposition and fertilization in boreal forests frequently reduces decomposition and soil respiration and enhances C storage in the topsoil. This enhancement of the C sink can be as strong as the aboveground biomass response to N additions and has implications for the global C cycle, but the mechanisms remain elusive. We hypothesized that this effect would be associated w
Aim: To provide a comprehensive description of the clinical features, biochemical characteristics, and outcomes of infants up to 90 days old with COVID-19. Moreover, to assess the severity of the disease and propose an effective management pathway. Methods: Retrospective single-center study spanning three years. Patient data includes age, sex, symptoms, comorbidities, blood and urine test results,
OBJECTIVE: To examine the prevalence and predictive factors for celiac disease (CD) after a diagnosis of type 1 diabetes (T1D) in children and adolescents, to improve the current screening guidelines.RESEARCH DESIGN AND METHODS: The association between sex, age at T1D diagnosis, HLA, and diabetes autoantibodies, and a diagnosis of CD was examined in 5,295 children with T1D from the Better Diabetes
Harp seals (Phoca groenlandicus), once present in the Baltic Sea, now stand extinct. During the Middle Neolithic period, they held significant dietary importance for the Pitted Ware Culture hunter-fisher-gatherers in Scandinavia. Because they are no longer available for ecological studies, little is known about their specific behavioural intricacies, such as diet, mobility, and reproductive strate
Conservation biological control in agricultural landscapes aims to promote natural enemy populations to mitigate short and long-term pest damage on crops. However, natural enemy populations in agricultural landscapes typically rely on crop pests and non-pest prey populations resulting in complex trait- dependent ecological interactions. Such communities, of pests, non-pest prey, and natural enemie
One of the most important challenges for modern society is how to feed the world in a sustainable manner. Agriculture is an essential part of food production, but at the same time it has many negative impacts on the environment, through for example pollution, nutrient leaching, and greenhouse gas emissions, and it is a big driver of biodiversity loss. Organic farming is a farming system that in ma
The interactions between dissolved organic matter (DOM) and mineral particles are critical for the stabilization of soil organic matter (SOM) in terrestrial ecosystems. The processing of DOM by ectomycorrhizal fungi contributes to the formation of mineral-stabilized SOM by two contrasting pathways: the extracellular transformation of DOM (ex vivo pathway) and the secretion of mineral-surface-react
Changes in farming practices over the past century have had negative influence on farmland biodiversity. Organic farming excludes most agrochemicals, such as inorganic fertilisers and synthetic pesticides, and can be an alternative to conventional farming. A recent meta-analysis indicates that there is on average 30% higher species richness on organically managed farmland compared to conventionall
Organic agriculture is a production system that aims at sustaining healthy soils, ecosystems and people by prohibiting the application of synthetic pesticides and fertilisers in crop production and by emphasising animal welfare in livestock breeding. This article shows that organic agriculture is characterised by higher soil quality and reduced nutrient or pesticide leaching compared to nonorganic
In this chapter three major concepts relating animal population dynamics to landscape change mediated by animal mobility are outlined: meta-population/community dynamics (affecting many habitat specialists), spillover (affecting e.g. ground-living predators), and landscape complementation (affecting e.g. central-place foragers). It is shown that all three concepts contribute to current understandi
This paper illustrates the potential use of the theory of planned behavior as a guiding framework for understanding intentions and behavior in geospatial data sharing in Tanzania. A structured questionnaire survey, was constructed and sent to local governments as well as academic and private organizations that are major producers and/or users of geodata. The questionnaire covered issues of how col
Many birds species connected to the agricultural landscape have for several decades fared poorly in Sweden, as well as in Europe as a whole. This is reflected in the decline of the Farmland Bird Index, an official EU indicator for farmland birds specifically, and biodiversity in general. The Swedish Board of Agriculture invited us to propose measures that will improve the conditions for farmland b
Climate change is increasingly posing a threat to biodiversity, both through its direct effects on organisms and through indirect effects resulting from changes in land use. Preserving biodiversity is an ethical obligation, but it is also increasingly being realised that biodiversity contributes to ecosystem services, i.e. ecosystem processes important for human needs and prosperity. In order to a
Next generation targeted sequencing of HLA-DRB1, -DRB3, -DRB4 and -DRB5 (abbreviated as DRB345) provides high resolution of functional variant positions to investigate their associations with type 1 diabetes risk and with autoantibodies against insulin (IAA), GAD65 (GADA), IA-2 (IA-2A) or ZnT8 (ZnT8A). To overcome exceptional DR sequence complexity due to high polymorphisms and extended linkage-di
