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Objectives: Panax ginseng (P. ginseng, C.A. Meyer) is suggested to improve blood glucose regulation, but evidence remains inconsistent. We examined whether consuming P. ginseng as a preload before a carbohydrate-rich meal modulates postprandial glucose and insulin responses. Methods: In a randomized, double-blind, crossover trial, 22 healthy middle-aged adults consumed P. ginseng tablets containin
BACKGROUND AND OBJECTIVE: Achieving adequate concentrations of beta-lactam antibiotics in patients with severe infections is challenging, and therefore therapeutic drug monitoring (TDM) would be optimal for guiding beta-lactam dosing, but is often limited by availability. UV/VIS spectrophotometry can quantify drug levels in saline, and if those levels truly reflect plasma concentrations, it could
BACKGROUND/AIM: Determining the causation of an injury in living individuals is a key task for forensic pathologists. However, little is known about sex-based differences in injury characteristics. The study aims to examine sex-based differences in single stab injuries to the trunk among assault survivors, to potentially identify injury patterns that could aid forensic assessment and help in the m
BACKGROUND: Early HIV diagnosis allows timely interventions to control HIV transmission. We have determined the proportion of recent infections among people living with HIV (PLHIV) enrolling to care in Ethiopia and identified factors associated with recent infection. METHODS: Participants (aged ≥ 15 years) newly enrolled in HIV care were recruited from urban clinics in central Ethiopia (2022-2024)
Lower urinary tract symptoms (LUTS) in men with benign prostatic hyperplasia (BPH) are associated with erectile dysfunction. Alpha-1-adrenoceptor antagonists are effective drugs for treating symptomatic BPH. Clinical data show improvements in LUTS by phosphodiesterase 5 inhibitors. This study aimed to evaluate effects of silodosin, a highly selective α1A-adrenoceptor antagonist, alone or in combin
OBJECTIVE: This analysis aimed to compare failure to rescue (FTR) after pancreatoduodenectomy across the Atlantic. SUMMARY BACKGROUND DATA: FTR, or mortality after development of a major complication, is a quality metric originally created to compare hospital results. FTR has been studied in North American and Northern European patients undergoing pancreatoduodenectomy (PD). However, a direct comp
BACKGROUND: ECG abnormalities are associated with adverse outcomes in the general population, but their prognostic significance in severe mental illness (SMI) remains unexplored. We investigated associations between no, minor, and major ECG abnormalities and fatal cardiovascular disease (CVD) among patients with SMI compared with controls without mental illness. METHODS AND RESULTS: We cross-linke
To assess (1) global longitudinal strain (GLS) by feature tracking cardiac magnetic resonance (CMR) in the sub-acute and chronic phases after ST-elevation infarction (STEMI) and compare to GLS in healthy controls, and (2) the evolution of GLS and regional longitudinal strain (RLS) over time, and their relationship to infarct location and size. Seventy-seven patients from the CHILL-MI-trial (NCT013
Objective. To compare the rate of severe infections after the onset of antineutrophil cytoplasmic antibody (ANCA)-associated vasculitis (AAV) with the rate in the background population, and to identify predictors of severe infections among patients with AAV. Methods. The study cohort was 186 patients with AAV diagnosed from 1998 to 2010, consisting of all known cases in a defined population in sou
Antenatal anxiety symptoms are not only a health problem for the expectant mother. Research has found that maternal anxiety may also have an impact on the developing baby. Therefore, it is important to estimate the prevalence of maternal anxiety and associated factors. The current study aims to estimate the prevalence of anxiety symptoms during the first trimester of pregnancy and to identify asso
The presence of diabetes mellitus is rarely addressed in acute lower limb ischaemia (ALLI). The aim of this study was to evaluate the outcome of local intra-arterial thrombolysis for ALLI in patients with diabetes mellitus (DM). Outcome of all thrombolytic events performed in an endovascular first-strategy centre during a 13-year period between 2001 and 2013 in patients with ALLI were followed to
Collagenase injection for Dupuytren's contracture is commonly administered without anesthesia. The authors studied the benefit of injecting local anesthesia before collagenase in reducing treatment-related pain. This prospective cohort study included 187 patients (mean age, 69 years; 80 percent men) at two orthopedic departments in Sweden. At one center, 161 consecutive patients scheduled for coll
The main monitoring method during labor is cardiotocography, CTG, which measures the fetal heartbeat, FHR, as well as the uterine contractions, TOCO. The CTG is a valuable tool in assessing the fetal status and it is evaluated intermittently by clinicians during the progress of the labor. However, abnormalities in the CTG are often non-specific which makes the interpretation difficult and inconsis
There is strong evidence that climate change has a direct impact on humans and extreme temperatures have been linked to negative health impacts and increasing mortality. The heat wave of 2018 caused up to 8.2% more deaths compared to the year before in Sweden, with higher impacts in other parts of the world. The fact that people spent almost 90% of their times indoors makes the indoor environment
This paper explores the impact of foreign aid on firm investment in physical capital using a dataset of 10 783 firms in 21 of the least developed countries. Using data from the World Bank Enterprise Surveys combined with sector allocated Official Development Assistance obtained from OECD CRS, no significant effect of aid was found. Fixed effects for country, sector and year did not change this res
The triple planetary crisis exerts high pressure on countries to transform their current economic system. The transition to a green economy is not only necessary to ensure sustainable development but also essential for countries to remain economically competitive. The neighbouring countries Panama and Costa Rica are both facing significant challenges under the green transition, despite their diffe
OBJECTIVE:: We aimed to test whether eight common recently identified single-nucleotide polymorphisms (SNPs), strongly associated with blood pressure (BP) in the population, also have impact on the degree of BP reduction by antihypertensive agents with different mechanisms. METHODS:: In 3863 Swedish hypertensive patients, we related number of unfavorable alleles of each SNP (i.e. alleles associa
Aim. To measure levels of anxiety among people accompanying consumers to the emergency department and to explore how anxiety influences satisfaction with care. Background. When people seek treatment in an emergency department they are often accompanied by a next-of-kin, family member or friend. While the accompanying person plays a vital role in providing psycho-social support to consumers, little
A number of bioactive natural products have by chromatographic techniques been isolated from extracts of various fungi, and their structures have been determined by spectroscopic and chemical methods. In the screening of fungal extracts for the inhibition of the binding of various ligands to CNS receptors in rat striatal membrane preparations in vitro, bioassay-guided fractionation of extracts of
The present study is centered on mechanisms of ischemic brain damage in hyperglycemic animals, and in those in which exaggerated intraischemic acidosis was induced by superimposed hypercapnia in normoglycemic animals. The initial experiments were focussed on the pathophysiology of postischemic seizures. Since hyperglycemic animals developed delayed postischemic hyperthermia, the question arose whe
