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Den problemformulering som ligger till grund för denna uppsats kretsar kring den stereotypiska bild som ofta blir central när vi talar om personer med funktionshinder. Studiens problemformulering grundas även på den ledande roll som media har för individers uppfattning av verkligheten och etablering av normer. Syftet med studien har således varit att studera hur personer med funktionshinder framst

This thesis investigates the impact of U.S. sanctions imposed between 2010 and 2012 on Iran’s non-oil exports. Using the Synthetic Control Method (SCM) as the baseline strategy, complemented by an Event Study and a standard Difference-in-Differences (DiD) model, the analysis shows that sanctions led to a sharp and persistent decline in Iran’s export performance relative to a counterfactual scenari

This study presents an example of when the government introduced a regulation that did not coincide research, professional ethics, responsibility or commitments, and led to a conflict between professionals and rulers.In the Swedish statutes regulating opioid maintenance treatment (OMT), a unique definition of the term opiate-dependency, the opiate rule, was introduced in 2010—restricting the targe

Every year, there are more than 2500 new international students coming to Lund University and starting their higher education path. A higher number of foreign students increased the international competitiveness of Lund University, but at the same time the international students had to face many problems for instance, culture shock and language barriers. In this report we focused on issues in teac

Variation in transcription factor 7-like 2 (TCF7L2), the strongest genetic risk factor for type 2 diabetes (T2D), may play a role in prostate cancer (PCa) depending on lifestyle factors. The aims of this study were to determine if TCF7L2 rs7903146 is associated with risk of PCa and if the association is modified by lifestyle factors independently of T2D status.

Background:The microRNA-205 (miR-205) has been shown to be deregulated in prostate cancer (PCa). Here we continue to investigate the prognostic and therapeutic potential of this microRNA.Methods:The expression of miR-205 is measured by qRT-PCR and in situ hybridisation in a well-documented PCa cohort. An AGO2-based RIP-Chip assay is used to identify targets that are verified with western blots, lu

Self-renewal of hematopoietic stem cells (HSCs) and leukemia-initiating cells (LICs) has been proposed to be influenced by low oxygen tension (hypoxia). This signaling, related to the cellular localization inside the bone marrow niche and/or influenced by extrinsic factors, promotes the stabilization of hypoxia inducible factors (HIFs). Whether HIF-1α can be used as a therapeutic target in the tre

We studied leukemic stem cells (LSCs) in a Smad4(-/-) mouse model of acute myelogenous leukemia (AML) induced either by the HOXA9 gene or by the fusion oncogene NUP98-HOXA9. While HOXA9-SMAD4 complexes accumulate in the cytoplasm of normal hematopoietic stem- and progenitor cells (HSPCs) transduced with these oncogenes, there is no cytoplasmic accumulation of HOXA9 in Smad4(-/-) HSPCs and as a con

Altered DNA methylation is often seen in malignant cells, potentially contributing to carcinogenesis by suppressing gene expression. We hypothesized that heritable methylation potential might be a risk factor for breast cancer and evaluated possible association with breast cancer for single nucleotide polymorphisms (SNPs) either involving CpG sequences in extended 5'- regulatory regions of candida

Popular Abstract in Swedish Höftfraktur är en vanlig skada, som huvudsakligen drabbar äldre kvinnor, och oftast orsakas av ett ringa våld. Det är vanlig orsak till funktionsnedsättning, sjuklighet och dödlighet hos de äldre. Både incidensen (antal nya fall per antal innevånare och år) av höftfrakturer och det totala antalet har ökat de senaste årtiondena. Höftfrakturer medför stora kostnader för sHip fractures are a common cause of morbidity and mortality in elderly patients, with a high risk of functional impairment and institutionalization. The incidence and number of hip fractures have increased during the recent decades and hip fractures consume considerable health-care resources. The incidence of hip fractures in Malmö, Sweden, 1992–95, is described in Paper I. The annual incidence pe

Adhesion is a key component of hematopoietic stem cell regulation mediating homing and retention to the niche in the bone marrow. Here, using an RNA interference screen, we identify cytohesin 1 (CYTH1) as a critical mediator of adhesive properties in primary human cord blood-derived hematopoietic stem and progenitor cells (HSPCs). Knockdown of CYTH1 disrupted adhesion of HSPCs to primary human mes

Genome-wide association studies (GWAS) identified the chromosome 15q25.1 locus as a leading susceptibility region for lung cancer. However, the pathogenic pathways, through which susceptibility SNPs within chromosome 15q25.1 affects lung cancer risk, have not been explored. We analyzed three cohorts with GWAS data consisting 42,901 individuals and lung expression quantitative trait loci (eQTL) dat

Background: Residual tumor volume (RTV) and extent of resection (EOR) have previously been shown to affect survival in glioblastoma (GB) patients. Quantitative radiological assessment (QRA) of these factors could potentially affect clinical decision-making in the postoperative period. Purpose: The first aim was to evaluate the reproducibility of different volume estimation methods of RTV and EOR b

The pathogenesis of prostate cancer is unclear, although experimental evidence implicates androgens as playing an important role. Infertile men frequently suffer from some degree of hypogonadism and may hence be hypothesized to be at lower risk of developing prostate cancer than fertile men. To test this hypothesis, we conducted a case-control study nested within "the Malmö Diet and Cancer Study"

Trots ett flertal överväganden om införande av en samtyckesreglering, har debatten kring en sådan reglering och våldtäktsbestämmelsen aldrig avstannat. Detta är ett ämne som väcker starka känslor, samt engagerar allmänheten och media i debatten. Flera sexualbrottsutredningar har tillsatts för att på uppdrag av regeringen utreda om en samtyckesreglering borde införas i den svenska lagstiftningen fDespite numerous deliberations of introducing a consent-based legislation, the debate has never ceased. This is a subject that evokes strong emotions among the public and media, which engages them in the debate. Several Sexual Offences Commissions have been assigned by the Government to investigate whether a consent-based regulation should be passed as law to reinforce the right to sexual self-de

Senaste årens forskning visar intressanta likheter mellan diagnosgrupperna ADHD och schizofreni gällande kognitiva nedsättningar, framförallt i form av brister i arbetsminnet. Trots att missbruk är vanligt i dessa diagnosgrupper saknas forskning på huruvida dessa samband är giltiga även vid en komorbid missbruksdiagnos. Syftet med studien var därför att undersöka hur arbetsminnesförmågan ser ut fö

Ett regelverk i förändring. De särskilt inrättade reglerna för beskattning av delägare i fåmansföretag för kapitalvinst eller utdelning är unika på många sätt. De första tjugofem åren ändrades reglerna tjugotre gånger, nästan en gång per år. Främst beroende på bakomliggande svängningar i politiken. I fåmansföretagen finns det som huvudregel inget reellt tvåpartsförhållande då delägaren styr bolageThe specially made rules for taxation of partners in close companies regarding dividend are unique in many ways. During the first twenty-five years these rules changed twenty-three times, almost once a year. This occurrence was mainly due to underlining political balance between purposes. In these close companies there’s often no real two-party relationship as the partner oversees the company. Thi

Swedish camera surveillance legislation has since 1977 contained requirements for permits, a consideration of the involved interests, and a duty to inform the surveilled. This applies to both authorities and citizens alike. The exceptions to these obligations have been few and restrictive. Over the years, surveillance legislation has been modernized to keep up with technological developments and p

Allt färre ungdomar läser på sin fritid och man har under de åtta senaste åren sett en minskning i antal biblioteksbesök bland ungdomar. Hur mycket man väljer att läsa påverkar resultaten i skolan. Detta påverkar i sin tur hela det svenska samhället. I uppsatsen ”Från biblioteket till unga: om bibliotekariens tankar kring kommunikation, organisation och marknadsföring till unga” undersöker vi