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Purpose The (14;18) translocation constitutes both a genetic hallmark and critical early event in the natural history of follicular lymphoma (FL). However, t(14;18) is also detectable in the blood of otherwise healthy persons, and its relationship with progression to disease remains unclear. Here we sought to determine whether t(14;18)-positive cells in healthy individuals represent tumor precurso
Pools of frozen biopsies from patients with squamous cell carcinoma (SCC) (n=29) actinic keratosis (AK) (n=31), keratoacanthoma (n=91) and swab samples from 84 SCCs and 91 AKs were analysed with an extended HPV general primer PCR and high-throughput sequencing of amplimers. We found 273 different HPV isolates (87 known HPV types, 139 previously known HPV sequences (putative types) and 47 sequences
BACKGROUND: Genetic variants in KLK2 and KLK3 have been associated with increased serum concentrations of their encoded proteins, human kallikrein-related peptidase 2 (hK2) and prostate-specific antigen (PSA), and with prostate cancer in older men. Low PSA concentrations in seminal plasma (SP) have been associated with low sperm motility. To evaluate whether KLK2 and KLK3 genetic variants affect p
Prostate-specific antigen (PSA) testing provides significant benefits by reducing prostate cancer mortality, but also leads to important harms by detecting clinically insignificant cancers. Hence, there are urgent needs for complementary tools for middle-aged men with modest PSA elevations in blood. This review includes research on prostate cancer biomarkers in blood published from March 2013 thro
Biokinetic data are important when calculating the absorbed dose to the patients and can also be used to find the optimal time between injection and imaging. To the authors' knowledge, there are no published biokinetic data in humans for (18)F-choline, except some distribution data at single time points. Four patients with suspicion of metastases due to biochemical recurrence (measurable prostate-
Vitamin D, parathyroid hormone (PTH) and calcium in blood are correlated with each other. Previous studies have suggested vitamin D to have anti-proliferative effects on tumor cells, whereas PTH may have carcinogenic effects. A cancer disease may influence calcium levels in blood, but less is known about calcium and its potential effect on cancer risk and survival. The aim of this study was to exa
Galiellalactone (GL) is a metabolite produced by the fungus Galiella rufa that presents antitumor and immunomodulatory activities. GL interferes with the binding to DNA of signal transducer and activator of transcription (STAT)-3 and also inhibits other signal pathways such as NF-κB, but the mechanism of action in this pathway remains unknown. In this study we report that GL inhibits vesicular sto
Background:Prostate cancer (PCa) is characterized by high tumor heterogeneity. In 2005, the fusion between the androgen-regulated gene TMPRSS2 and members of the ETS family was discovered in prostate cancer. In particular, fusion of TMPRSS2 with ERG was found in approximately 50% of prostate cancers and considered as an early event in the onset of the disease. The prognostic value of this fusion i
The shelterin complex protects chromosomal ends by regulating how the telomerase complex interacts with telomeres. Following the recent finding in familial melanoma of inactivating germline mutations in POT1, encoding a member of the shelterin complex, we searched for mutations in the other five components of the shelterin complex in melanoma families.
Enrichment of rare cells from peripheral blood has emerged as a means to enable noninvasive diagnostics and development of personalized drugs, commonly associated with a prerequisite to concentrate the enriched rare cell population prior to molecular analysis or culture. However, common concentration by centrifugation has important limitations when processing low cell numbers. Here, we report on a
Polymorphisms associated with prostate cancer include those in three genes encoding major secretory products of the prostate: KLK2 (encoding kallikrein-related peptidase 2; hK2), KLK3 (encoding prostate-specific antigen; PSA), and MSMB (encoding beta-microseminoprotein). PSA and hK2, members of the kallikrein family, are elevated in sera of men with prostate cancer. In a comprehensive analysis tha
Signal transducer and activator of transcription 3 (STAT3) is known to be involved in the progression of prostate cancer (PCa) and is a key factor in drug resistance and tumor immunoescape. As a result, it represents a promising target for PCa therapy. We studied the effects of the STAT3 inhibitor galiellalactone (GL) on tumor growth and metastatic spread in vitro and in vivo. The effect of GL on
Apelin, a ligand of the APJ receptor, is overexpressed in several human cancers and plays an important role in tumor angiogenesis and growth in various experimental systems. We investigated the role of apelin signaling in the malignant behavior of cutaneous melanoma. Murine B16 and human A375 melanoma cell lines were stably transfected with apelin encoding or control vectors. Apelin overexpression
Resonant photoelectron spectroscopy (RPES) has been used to probe electronic structure properties of the closed-shell [FeII(CN)6]4− and open-shell [FeIII(CN)6]3− prototype transition metal complexes in aqueous solution. Site-selective Fe 2p (L-edge) RPES mapsprovide new insight into spin-coupling processes at the core-excited metal centers, with autoionization of [FeIII(CN)6]3− showing a dramatic
LUCSUS Annual Report 2022 Annual Report 2023 LUND UNIVERSITY CENTRE FOR SUSTAINABILITY STUDIES (LUCSUS) 3LUCSUS ANNUAL REPORT 2023 Editors: Noomi Egan Cover illustration: Catrin Jakobsson Lund University Photo: page 5: UN Climate Change/Kiara Worth, page 6: Peter Kornacher, also photos by Cecilia von Arnold and Noomi Egan. Words from the director While new to my role as di- rector, I have had the
https://www.lucsus.lu.se/sites/lucsus.lu.se/files/2024-04/LUCSUS%20AR%202023_high.pdf - 2026-04-20
Modeling of real-world fuels and fuel mixtures in combustion engines, using computational fluid dynamics (CFD), calls for the development of compact and computationally efficient chemical kinetic mechanisms. To improve the modeling capabilities of multicomponent fuels it is necessary to transition from the single-component descriptions of fuels and move toward more complex, accurate multicomponent
Like other Western legal systems, the Swedish legal system constructs objectivity as an unemotional state of being. We argue that the enactment of objectivity in situ relies on objectivity work including emotion management and empathy. Building on qualitative interviews and observations in Swedish district courts, we analyse courtroom interaction through a dramaturgical lens, highlighting tacit siLike other Western legal systems, the Swedish legal system constructs objectivity as an unemotional state of being. We argue that the enactment of objectivity in situ relies on objectivity work including emotion management and empathy. Building on qualitative interviews and observations in Swedish district courts, we analyse courtroom interaction through a dramaturgical lens, highlighting tacit si
Nyhetsbrev 2018 till dig som deltar i ett världsunikt projekt Det är sjätte gången som Ingrid kommer till GÅS- projektets mottagning i Malmö, och hon har nu hunnit fylla 102 år. Hon har varit med sedan forsk- ningsprojektet började och tycker att det har varit in- tressant att få vara med och hjälpa till med forskning, särskilt eftersom hon själv har blivit äldre. Vissa delar av undersökningen tyc
https://www.geriatrik.lu.se/sites/geriatrik.lu.se/files/nyhetsbrev2018_fin.pdf - 2026-04-20
Här hittar du information om hur du ansöker om examen, vad som gäller och hur du får tillgång till ditt examensbevis. Du får också information om hur du delar och verifierar din examen digitalt. Ansök om examenNär du är klar med din utbildning vid Lunds universitet behöver du själv ansöka om examen. Det kostar inget att ansöka.Innan du ansöker: Kontrollera att alla kurser som ska ingå i din examen
https://www.lu.se/student/examen-och-karriar/examen - 2026-04-20
Microsoft Word - Management Response - Evaluation of Programme Work Methods 2017 (FINAL) 1 2018-03-20 Management Response Evaluation of Programme Work Methods of the Raoul Wallenberg Institute of Human Rights and Humanitarian Law Background In August 2017, the Swedish International Development Cooperation Agency (Sida) commissioned an external evaluation (originally referred to as “review”) of pro
https://rwi.lu.se/app/uploads/2019/02/RWI-Management-Response-Evaluation-of-Programme-Work-Methods.pdf - 2026-04-13
