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Agricultural soils are the most important anthropogenic source of nitrous oxide (N2O) emissions. This occurs via two main pathways: (1) from microbial-mediated oxidation of ammonium to nitrite and nitrate; and (2) denitrification. Most agro-ecological models explicitly deal with these two pathways albeit with different degrees of process understanding and empiricism. Models that integrate the impa
Introduction: The emergence of durable and potentially curative cell and gene therapies (also known as advanced therapy medicinal products) with high price tags is challenging conventional health care payment systems. Among these are gene therapies in various phases of development for haemophilia A and B. The emergence of these therapies comes with clinical and economic uncertainties for payers, p
Biological nitrogen fixation (BNF) from grain legumes is of significant importance in global agricultural ecosystems. Crops with BNF capability are expected to support the need to increase food production while reducing nitrogen (N) fertilizer input for agricultural sustainability, but quantification of N fixing rates and BNF crop yields remains inadequate on a global scale. Here we incorporate tw
Enhanced warming in the Arctic (Arctic amplification, AA) in the last decades has been linked to several factors including sea ice and the Atlantic Multidecadal Oscillation (AMO). However, how these factors contributed to AA variations in a long-term perspective remains unclear. By reconstructing a millennial AA index combining climate model simulations with recently available proxy data, this wor
Improved agricultural management plays a vital role in protecting soils from degradation in eastern Africa. Changing practices such as reducing tillage, fertilizer use, or cover crops are expected to enhance soil organic carbon (SOC) storage, with climate change mitigation co-benefits, while increasing crop production. However, the quantification of cropland management effects on agricultural ecos
If you really want to know how much Australia contributes to the amount of carbon dioxide (CO₂) in the atmosphere, you have to study all the “sources” and “sinks”.Sources release CO₂ into the atmosphere, while sinks take it out. There are sources from human activities, such as burning fossil fuels, and there are natural sinks such as plants absorbing CO₂. You can tally it all up on a balance sheet
Introduction Youth placed in out-of-home care is a large and highly vulnerable group at high risk of negative developmental outcomes. Given the size and extent of negative developmental outcomes for youth placed in out-of-home care, interventions to help this vulnerable group navigate successfully towards independent living and promote wellbeing across a spectrum of outcome areas are needed. To da
Pollen-based quantitative vegetation reconstructions using multiple sedimentary basins from the same area, along with their quantified relevant pollen source areas, are a powerful means to study how long-term human impact has affected vegetation and shaped the currently protected heritage landscapes at different spatial scales. Our study presents the outcome of a palynological investigation in Kar
Australia, characterized by extensive and heterogeneous terrestrial ecosystems, plays a critical role in the global carbon cycle and in efforts to mitigate climate change. Prior research has quantified vegetation productivity and carbon balance within the Australian context over preceding decades. Nonetheless, the responses of vegetation and carbon dynamics to the evolving phenomena of climate cha
In medical and biomedical education, traditional teaching methods often struggle to engage students and promote critical thinking. The use of AI language models has the potential to transform teaching and learning practices by offering an innovative, active learning approach that promotes intellectual curiosity and deeper understanding. To effectively integrate AI language models into biomedical e
Novel biomarkers are key to addressing the ongoing pandemic of type 2 diabetes mellitus. While new technologies have improved the potential of identifying such biomarkers, at the same time there is an increasing need for informed prioritization to ensure efficient downstream verification. We have built BALDR, an automated pipeline for biomarker comparison and prioritization in the context of diabe
Data standards for quality registries should be evidence-based and follow guideline recommendations. To optimally monitor quality of care, not only patient-level variables, but also centre-level variables need to be included. Here we describe the development of variables to audit the structure and processes in cardiac rehabilitation for patients after myocardial infarction, and the resulting data
Forests are invaluable terrestrial ecosystems with considerable economic, ecological, and environmental benefits. Bark beetles have been recognized as one of the major causes of forest disturbance, and climate change can exacerbate their impact, leading to more tree mortality. Early detection of bark beetle attacks is vital to reduce forest loss and devastating consequences. This study examines th
Uncertainty in our calculations of a system reveals the limits of our knowledge. This limitation makes model representations of the Earth system challenging and our predictions less reliable. However, despite appearing chaotic and non-linear, a system always follows a deterministic trajectory, which can often be expressed probabilistically. Building on this concept, this thesis applies data assimi
There are many explanations for the so-called rigor-relevance gap in academic research on strategic management. This Element reviews the existing literature on the matter and argues that it must go beyond the typical explanations of knowledge and language differences and look at more fundamental, societal, and cultural explanations. The empirical focus of this Element is the history and possible p
The terrestrial carbon cycle is an important component of the global carbon budget due to its large gross exchangefluxes with the atmosphere and their sensitivity to climate change. Terrestrial biosphere models showlarge uncertainties in simulating carbon fluxes, which impact global carbon budget assessments. The land surfacecarbon cycle is tightly controlled by soil moisture through plant physiol
Atmospheric inversions have been used for the past two decades to derive large-scale constraints on the sources and sinks of CO2 into the atmosphere. The development of dense in situ surface observation networks, such as ICOS in Europe, enables in theory inversions at a resolution close to the country scale in Europe. This has led to the development of many regional inversion systems capable of as
