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Nucleotide metabolism and replication of nucleic acids are processes of fundamental importance. A crucial enzyme in nucleotide metabolism is dUTPase (E.C. 3.6.1.23), that catalyses the hydrolysis of dUTP to dUMP and pyrophosphate. The activity of the enzyme has influence on the outcome of DNA replication and complete loss of enzyme activity is lethal, while a decreased activity promotes increased
The molecular process under which message in DNA is relayed onto RNA is called transcription, and it accomplished through involvement of so-called transcription factors. Zinc finger proteins are one of the most abundant classes of regulatory proteins in eukaryotic cells where they play central roles in a variety of cellular activities. A classical zinc finger is a small protein motif with a simple
This thesis describes the design and characterisation of a vacuum ultraviolet scanning photoelectron microscope as well as results from studies of laterally inhomogeneous surfaces. The instrument utilises synchrotron radiation from an undulator at the 550 MeV storage ring at the MAX-laboratory. The beamline is comprised of a plane-grating monochromator with a Kirkpatrick-Baez objective and a graz
The setting for this study is Swedish film culture of the 1920s, which has been studied with a focus on representations of masculinity and gender relations according to four themes: 1) children and youth 2) fatherhood and love 3) sexuality and popularity 4) ethnicity and racial stereotyping. The rise of new consumer culture in the first decades of the 20th century created turmoil between traditi
Popular Abstract in Swedish Polymerer och tensider är molekyler vi stöter på i vårt vardagliga liv, när vi bär hem våra matvaror i plastkassar, tvättar håret, målar huset eller tar en värktablett. Klassificeringen polymer är väldigt bred och innefattar allt från naturliga polymerer som cellulosa, till syntetiska polymerer som polystyren. Polymerer består av små, repeterande enheter, kallade monomeComplexes formed between oppositely charged polyions and surfactant ions are known to have very rich phase behaviour in bulk solution. The work in this thesis investigates the possibilites of using such complexes as surface coatings. Stoichiometric polyion-surfactant ion complexes “complex salts” (CS) consisting of alkyltrimethylammonium surfactant ions and polyacrylates are typically insoluble i
Popular Abstract in Swedish De flesta cancerformer uppvisar förvärvade kromosomavvikelser. En del enklare avvikelser har visat sig förekomma enbart i en viss tumörform och kan därför användas som diagnostiska markörer. I de flesta fall föreligger emellertid ett komplext och ospecifikt avvikelsemönster, ibland med ett mycket kraftigt ökat antal kopior av vissa DNA-sekvenser, så kallad genamplifieriAcquired genetic abnormalities are found in all types of malignant tumours and may contribute to neoplastic processes by altering protein structure or dosage. Many bone and soft tissue tumours (BSTT) are characterised by complex patterns of chromosome changes, including extensive intratumour heterogeneity and amplification of DNA sequences. The results presented in this thesis demonstrate that the
Popular Abstract in Swedish Denna avhandling undersöker dagvatten som en resurs i svensk urban miljö. Fokus har varit öppna dagvattensystem för flödeskontroll och uppsamlingssystem för regnvatten. För att analysera realiserandet av öppna dagvattensystem, presenteras två fallstudier; Augustenborg i Malmö och Bäckaslöv våtmark i Växjö. De kvarhållande och fördröjande effekterna som uppnås med gröna This thesis investigates the beneficial use of stormwater in Swedish urban environments. The focus has been on open stormwater systems for source control, as well as rainwater collection systems. To analyse the implementation of open stormwater systems, two case studies are presented: Augustenborg in Malmö and Bäckaslöv wetland in Växjö. The retention and detention effects of green-roofs have been
Popular Abstract in Swedish Svenska Pommerns historia är en del av den svenska historien. Mellan 1648 och 1815 hörde den tyska Östersjöprovinsen till det svenska väldet. Denna avhandling skildrar människorna och deras syn på Sverige under de sista hundra åren av svensk tillhörighet mellan 1720 och 1815. Hur påverkades provinsens invånare av att å ena sidan räkna sig till den tyska kulturen och å aBetween 1648 and 1815, Swedish-Pomerania, at the Baltic shore, belonged to the crown of Sweden. It was both a part of the Holy Roman Empire of German Nation and the Swedish realm. The port town of Stralsund played a key roll in the Swedish economy at the Baltic Sea, whereas the university town of Greifswald was the intellectual centre. On a cultural level, this situation opened up for a double ins
The object of this thesis is to describe, analyze and understand the terms and meanings of the public information and the political communication for local democracy, in today´s media landscape, out of the interaction between the main parties of the local society in Sjöbo and Ystad and from the stand point of earlier research and theories. The study has analyzed the actions performed by citizens,
Popular Abstract in Swedish POPULÄRVETENSKAPLIG SAMMANFATTNING De två vanligaste orsakerna till operationer på blodkärlen är pulsåderförträngningar och pulsådervidgningar, så kallade aneurysm. Förträngningarna beror på åderförfettning eller förkalkning och orsakar en försämrad blodtillförsel bortom det förträngda partiet. Då hjärtats kranskärl är förträngda kan det resultera i kärlkramp, då benetsABSTRACT In humans, synthetic vascular grafts heal with a limited ingrowth of endothelium. This fact might be responsible for inferior performance of synthetic grafts compared with native artery.Endothelial cells can be autotransplanted (seeded) into the graft in an effort to improve graft function. The attachment of endothelial cells to different graft materials was investigated in vitro (I). In
Denna bok handlar om de franska S:t josefsystrarna och deras missionsverksamhet i Skandinavien från mitten av 1800-talet och fram till 1950-talet med fokus på deras skol- och sjukvårdsverksamhet samt den specifika kvinnokultur som de representerade. Female Counter-Culture and Catholic Mission. The St Joseph Sisters in Denmark and Sweden 1856-1936 In May 1856, four Catholic sisters arrived in Denmark and established a community in a small basement of a building close to the Catholic parish church in Copenhagen. These Catholic sisters belonged to a French religious congregation named "La Congregation des Sœurs de Saint-Joseph de Chambéry", whi
NOx pollution from diesel engines has been stated as causing over 10 000 pre-mature deaths annually and predictions are showing that this level will increase [1]. In order to decrease this growing global problem, exhaust after-treatment systems for diesel engines have to be improved, this is especially so for vehicles carrying freight as their use of diesel engines is expected to carry on into the
Comparative empirical studies of the link between economic growth, carbon emissions and ecological footprints (e.g. Fritz and Koch 2016) suggest that current Western production and consumption patterns and welfare standards are incompatible with environmental limits and IPCC climate targets. In the absence of evidence for absolute decoupling of economic growth, material resource input and carbon e
The use of public demand to spur innovation has recently seen a very significant in-crease in political support. Such a policy promises improvement of public services on all state levels, combined with a contribution to innovation dynamics. It has become clear that strong efforts are needed to mobilise procurement at all state levels for inno-vative markets. These efforts need to be based on a bet
Offentlig upphandling är ett ämne där många har synpunkter och ämnet har också debatteras frekvent i media och inom den juridiska diskursen. Inte minst handlar det om miljökrav där också fler och fler använda sig ut av dessa krav i sina upphandlingar. Ett samordnade och stödjande arbete med råd om hur man kan ställa miljökrav har bedrivits, inte minst inom ramen för Miljöstyrningsrådet (MSR). SamPublic procurement has been frequently debated in news-media but also in the legal discourse, during the last years. Especially regarding the possibility to set environmental goals and we can see these requirements being more frequently used. Coordinating and supporting functions has been developed with advice on how to set these types of requirements. For example has MSR (Miljöstyrningsrådet) bee
Popular Abstract in Swedish För att öka förståelsen för hur ljud sprider sig och strålar från byggnadskonstruktioner utförda i lättbyggnadsteknik så behövs teoretiska beräkningsmodeller. Sådana modeller presenteras i avhandlingen. Med lättbyggnadsteknik avses konstruktioner som inte är massiva, exempelvis väggar och bjälklag bestående av trä- eller stålreglar/bjälkar. Stegljudet, det vill säga det
The objective of this thesis is to analyze the development and diffusion of Photovoltaic Power Systems (PVPS’) in Denmark, identify drivers and barriers for further dissemination, and explore how the policy framework supports the diffusion of PVPS’’ and thus contribute to learning within this field. The focus is on grid-connected PVPS’, which are either used as an “add-on” device or integrated int
Introduction: The Emergency Department (ED) is a complex environment. Patients present with many different complaints with alternating severity. This setting makes time efficiency and diagnostic accuracy crucial. The use of checklists in medicine has been successful in several medical fields, such as in reducing surgical complications and in decreasing catheter-related bloodstream infections in th
