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Nucleic acids are well recognized targets for platinum-based anticancer drugs, with RNA and DNA being kinetically comparable. In the case of RNA, previous studies have shown that the reaction between small duplex RNAs (dsRNAs) and monoaquated cisplatin (cis-Pt(NH3)2Cl(OH2)(+), ) can be followed by the metal induced hyperchromicity occurring directly after addition of to e.g. microRNA mimics. In th

Popular Abstract in Swedish I stormaktstidens Sverige utgavs en fornsaga där den mytiske svenske kungen Vilkinus ligger med havsfrun. Under denna tid kunde vanliga människor som påstod sig ha sådana förbindelser dock råka illa ut. År 1630 förhördes pigan Anna Larsdotter, som misstänktes ha fött näckens monstruösa avkomma. ”Trollkarlen” Peder Jönsson avrättades tio år senare för könsumgänge och pakThis dissertation examines conceptions of erotic nature spirits and their association with demonic sexuality in 17th and 18th century Sweden. Its purpose is to reconstruct the various cultural and symbolic meanings which such notions had for the society of the day. Cultural history and the analytical concepts culture(s), liminality and figures of thought provide the general framework of the study.

This study focuses on the development of unstructured models, including both substrate and product inhibition, that predict the cultivation of Actinobacillus succinogenes and Basfia succiniciproducens on a mixture of C5 and C6 sugars, similar to the sugar composition contained in spent sulphite liquor, the liquid waste stream from the sulphite pulping process. The main sugar monomer contained in t

Background: Phonological disorders are common in 3-year-olds born with cleft palate compared to non-cleft peers. However, published results have been based on small samples. The purpose was to expand the knowledge on phonology of Swedish-speaking 3-year-olds with unilateral cleft lip and palate (UCLP), treated with primary palatal closure in one or two stages. Methods: The phonology of 26 children

The thesis is about the historical transformation of Mekeo society. lt is not about the Mekeo as cultural group but about Mekeo society as part of a larger Papuan world of social reproduction. The analysis is anchored in the study of the regional exhange systems which it traces, temporally, through the different historical circumstances influencing the Mekeo area First the pre-colonial regional s

Både i varumärkesrätten och marknadsföringsrätten förekommer situationer när en part i en tvist behöver bevisa att dess märke eller produkt uppfattas på ett visst vis på marknaden. Omständighetens uppfattning om ett föremål (en vara/tjänst eller ett märke) är bland annat av relevans för de markandsföringsrättsliga bestämmelserna för vilseledande efterbildning och renommésnyltning, men även för de Both in trademark law and marketing law there are situations when a party in a case needs to present evidence that supports that its trademark or product is perceived in a certain way by the relevant public. The relevant public’s perception of the object in question is relevant in marketing law including the provisions for passing off and misleading imitations and in trade mark law including the p

The study aimed at (a) investigated the ability of potential lactic acid bacteria (LAB) to ferment quinoa milk, and (b) formulating a method for producing fermented quinoa milk. To meet the objectives, Lactobacillus pentosus and Pediococcus pentosaceus two native bacterial strains were tested. Quinoa milk elaboration was optimized at laboratory scale by selecting an appropriate quinoa/water propor

This thesis aims at addressing the question of the representation of the Other within current dominant visual media. The Other, in the context of this thesis, refers to any minority community group identified as different from a certain dominant norm; depending on the context it could correspond to groups such as Women, Afro-Americans or Arabs. Here the group concerned will be the migrant, who hav

Antal fordon i trafiken börjar bli allt fler och fler. Detta leder till att vägar behöver underhållas emellanåt. För att åtgärda vägarna så krävs det vägarbetare på plats, 90% av dessa vägarbetare känner oro dagligen på sitt jobb. Anledningen till deras oro är att många trafikanter inte tar någon hänsyn till vägarbetare, de kör aggressivt, hänsynslöst och över hastighetsgränsen. Under åren 2003-20The number of vehicles in traffic is increasing. This means that roads need to be maintained regularly. To repair the roads, road workers are required on site. Ninety percent of these road workers feel anxious daily at their work. The reason for their concern is that many road users do not pay any attention to road workers, they drive aggressively, ruthlessly and over the speed limit. During the y

Abstract Aid-tying is considered costly and ineffective to recipient countries and it is estimated that costs increases by as much as 30 per cent due to its practice. The Paris Declaration on enhanced aid effectiveness suggested an end to tied aid. The purpose of this paper is to give a review of the development of aid-tying in the European countries in the last thirty years. It will also look at

The main instrument to combat the abuse of a dominant position within the European Union is Article 82 ECT. It is not intended to prohibit dominance per se, but rather to offer a vehicle for the reaction to actual or potential abuses of undertakings. In order for the Article to come into play the prime requirement is that the undertaking undergoing scrutiny is indeed dominant. Dominance is a relat

The policy of the European Union concerning promotion of employment is among other things to support and complement the member states in matters relating to workers' right of participation. For this reason the EU has developed the open method of co-ordination (OMC), which entails a form of cooperation by comparing studies of national systems and exchange of experiences to reach the goals of th

Populärvetenskaplig sammanfattning: I Kakeled på Kinnekulles sydvästsluttning, Västergötland, finns en blottad lagerföljd från överkambrium. Överkambrium är en tidsperiod som sträckte sig från ca 525 till 500 miljoner år sedan. Avsättningen i det överkambriska havet var extremt långsam (1-10 mm/1000 år). Bottenförhållandena var mer eller mindre syrefria, varför nedbrytningen av det organiska materUpper Cambrian strata are well exposed in an old quarry at Kakeled on south-western Kinnekulle, south-central Sweden. The exposures consist of finely laminated alum shale with lenses and beds of dark grey limestone (stinkstone or orsten), and a few thin layers of sandstone. A 6.20 m thick section in the central part of the quarry has been measured and sampled in order to establish the succession o

Power quality is an important issue for the distribution network companies. They must guarantee the electricity supply fulfilling the requirements for the consumers. In this thesis we investigate specifically voltage requirements. We use transformers and tap changers to see how the voltage works in an electric system and we analyze the relationships with other aspects of the system’s performance,

Strandskyddslagstiftningen och allemansrätten är unika globalt sett. Strandskyddets syfte är att bevara den goda livsmiljön för växter och djur samt att trygga förutsättningarna för allmänhetens tillgång till kusterna. 1 juli 2009 trädde den förändrade strandskyddslagstiftningen i kraft. De huvudsakliga målen med förändringen var enligt propositionen att främja utvecklingen i landsbygden med god tShoreline protection law and the right of commons are unique from a global perspective. The purpose of the shoreline protection law is to promote and maintain a good habitat for plants and animals and to secure the basis for the public's access to the coastline. On the 1st of July 2009 the new and changed shoreline protection law took effect. The main purpose of the change was to promote rura

Imaging of stellar surfaces in visible wavelengths is one of the current frontiers in astronomy. With a few exceptions, stars can not be seen in visible light as anything but point objects with current technology. Being able to properly image stars would open up the door to a vast field of new discoveries, permitting direct studies of phenomena such as rotationally deformed stars, circumstellar di

The purpose of this study is to examine the optimal hedge ratio for the currency exposure of foreign investments. The optimal hedge ratio is determined after evaluating our portfolios from the three perspectives; ex-ante, ex-post and profit/loss. The ex-ante perspective is examined by the usage of historical simulation to calculate VaR on 11 portfolio pairs. Each pair consists of a portfolio with

The objective of this study is to reach a better understanding of accidents on Swedish roads involving tractors and to suggest ways of preventing them. In an earlier study we analyzed police-reported fatal accidents and accidents that led to physical injuries from 1992 to 2005. During each year of this period, tractors were involved in 128 traffic accidents on average, an average of 7 people were

With the advent of multimodality therapy, the overall five-year survival rate from childhood cancer has improved considerably now exceeding 80% in developed European countries. This growing cohort of survivors, with many years of life ahead of them, has raised the necessity for knowledge concerning the risks of adverse long-term sequelae of the life-saving treatments in order to provide optimal sc