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BACKGROUND: There is limited data regarding SARS-CoV-2 vaccine uptake in people with HIV (PWH) compared to people without HIV (PWoH).METHODS: Swedish nationwide study of individuals born 1930-2003, assessing SARS-CoV-2 vaccine uptake of 1-5 doses by HIV-status from first SARS-CoV-2 vaccination (2020-12-27) until 2023-02-23. PWH were categorized by prioritization: clinically vulnerable (CD4+ T-cell
Objectives: To examine the effects of thiopurine exposure during pregnancy on intrahepatic cholestasis of pregnancy (ICP) in systemic lupus erythematosus (SLE) and inflammatory bowel disease (IBD) pregnancies using nationwide data from Swedish healthcare registers. Methods: This register-based cohort study included all singleton pregnancies with prevalent SLE or IBD in Sweden, 2007-2022. Exposure
Background Obesity is increasing among patients with inflammatory bowel disease, but bariatric surgery has been rare in this group owing to concerns about worsening the inflammatory bowel disease. The aim of the study was to evaluate inflammatory bowel disease-related outcomes following bariatric surgery. Methods Nationwide cohort of all adult patients in Sweden between 2007 and 2020 with obesity
Att säkerställa tillräcklig bärighet för cykelvägar är nödvändigt för att undvika skador. Då de är tunna och smala konstruktioner är de väldigt känsliga för kantskador från passager av tunga fordon. Två viktiga faktorer som påverkar den här skadetypen är bristen på kantstöd och ett ökat fuktinnehåll i de obundna konstruktionslagren. Tre instrumenterade fullskaliga cykelvägskonstruktioner med olikaAssuring sufficient structural stability of cycle paths is important toavoid distress. Being thin and narrow structures, they are highly susceptibleto edge cracking by passings of heavy vehicles. Two importantfactors that affect distress are lack of lateral support at the edgeand increased moisture content in the unbound granular materials.Three full-scale instrumented cycle path structures with d
In early December 2024, South Korea faced a political shock: then-President Yoon Suk-yeol declared martial law late one night—only to lift it just six hours later, following mass protests and a parliamentary backlash. Within a week, he was impeached, and now he and his wife are in prison.
Background: India's agriculture and food sector is the backbone of the nation, sustaining a large portion of the population and contributing to global exports. Small and medium-sized enterprises (SMEs) generate the bulk of the world's food despite lacking adequate technological infrastructure and operational standards. This study identifies and evaluates the main blockchain challenges affecting fo
Samhället behöver utvecklas i en hållbar riktning. Ett sätt att bidra till det är att överflytta motoriserade transporter till hållbara färdmedel, som cykling. För att öka cyklingen spelar infrastrukturen en viktig roll och det behövs cykelvägar av bra kvalitet. Det saknas emellertid kunskap om cykelvägarnas nedbrytning. Den här artikeln ämnar undersöka vilken typ av skador som återfinns på svenskThere is a need to move society in a sustainable direction. One way to contribute to this move is to change to more sustainable transport modes, such as cycling. To increase cycling, the infrastructure is important, and good quality cycle paths are needed. However, little is known about the degradation of cycle paths. This paper aims to investigate what modes of pavement distress are found on muni
The reliability of a critical industrial component is decided by the durability of the weakest joint or spot. For applications involving high-temperature operational conditions especially coupled with corrosive environments like fuel cell interconnections, molten metal baths, etc., the joints are the most vulnerable regions for catastrophic failure due to localized material degradation by selectiv
Cyklisters åkkomfort, kopplat till cykelvägens textur och jämnhet, har hittills inte undersökts på ett uttömmande vis. Det beror delvis på att det saknas tillståndsbedömningsmetoder som är speciellt utvecklade för cykelvägarnas lägre hastighetsgränser och begränsade utrymme. Det behövs textur- och jämnhetsmått som passar cyklisters, och inte bilisters, upplevda åkkomfort. I den här artikeln presenCyclists’ riding comfort, related to pavement texture and unevenness, has not been thourougly investigated, partly due to the lack of condition assessment methods specifically adapted to the speed and space limits on cycle paths. Metrics that better describe the perceived comfort of cyclists, rather than that of car users, are needed. In this paper a novel method, the Bicycle Measurement Trailer (
How to estimate the economic returns of public science is a longstanding but equally challenging topic in quantitative science studies. In this paper, we exploit the staggered foundation of the SENAI Innovation Institutes (ISI) in Brazil since 2012 to estimate their effects on GDP using a difference-in-differences (DiD) approach. Building on historical and institutional insights from interviews on
Ett vanligt problem på cykelvägar är kantsprickor, vilka påverkar trafiksäkerheten och framkomligheten för cyklister negativt och bidrar till ökade underhållskostnader. Cykelvägarna är extra känsliga för den här problematiken då de både är tunnare och smalare än bilvägar. Ett par passager av tunga fordon vid ogynnsamma tidpunkter kan räcka för att cykelvägens kant ska knäckas. Bärförmågan hos åttaA recurrent challenge on cycle paths are edge cracks, which affect the traffic safety and accessibility of cyclists and produce high maintenance costs. Being both structurally thinner and narrower structures than roads, the cycle paths are extra prone to this problem. A few passages of heavy vehicles in unfavourable conditions might be enough to break the edge. The load-bearing capacity of eight m
Introduction: Patients with severe haemophilia A (HA) with no family history of haemophilia will be diagnosed upon their first bleeding event. Methods: Herein, we studied the effects of lack of family history in HA and the subsequent delay of diagnosis on bleeding pattern and early treatment, as well as on the risk of inhibitor development. For this purpose, data on 1237 severe HA patients with kn
This paper reports on lessons learned during the design of the vessels, including the risk assessments; during the actual build/retrofit; and during the vessels’ operation. The focus is on the gained knowledge, to serve as proofs of concept and as a starting point for other methanol vessel conversions.
En förflyttning av bilresor till cykeltrafik har många fördelar, t.ex.förbättrad folkhälsa genom ökad fysisk aktivitet och minskadeföroreningar och trängsel. En slät yta med adekvat friktion är viktigt förcyklisternas trafiksäkerhet, komfort och framkomlighet. Sprickor ochojämnheter är vanligt förekommande underhållsrelaterade brister som ärkopplade till cykelvägens nedbrytning. Ett syfte med den A shift in modal share from car driving to cycling has many benefits, e.g.,health benefits from increased physical activity and less pollution andcongestion. A smooth cycle path surface with sufficient friction isimportant for cyclist traffic safety, comfort and level of service. Cracks andsurface unevenness are frequent maintenance-related deficienciesassociated with the degradation of the struct
Att ersätta bilresor med cykelresor har många fördelar, både ur ett individ- och samhällsperspektiv, t.ex. bättre hälsa genom ökad fysisk aktivitet, lägre nivåer av föroreningar och trängsel. Det finns dock vissa potentiella problem med en sådan förändring. Cyklister löper exempelvis högre risk för trafikolyckor per fordonskilometer än bilförare. Denna risk måste minimeras för en optimal övergång A shift in modal share from car driving to cycling has many benefits, bothfrom individual- and societal perspectives, e.g., better health from anincrease in physical activity, lower levels of pollution and congestion.However, there are also some potential problems with such a shift. Cyclistshave a higher risk of traffic incidents per travelled kilometre than cardrivers. This risk needs to be minim
The accumulation of heavy metals in soils, often resulting from socio-economic development, poses a significant environmental challenge. Metallic elements can be adsorbed by organic matter and minerals in the soil, eventually accumulating in river sediments. This study aims to assess the extent of metal contamination in the sediments of the El Maleh River and its estuary in the Mohammedia region o
Introduction: Carbon monoxide (CO) is a leading cause of environmental poisoning in the United States with substantial mortality and morbidity. The mechanism of CO poisoning is complex and includes hypoxia, inflammation, and mitochondrial dysfunction. Currently both biomarkers and therapies for CO poisoning are limited and require new approaches. Methods: Rats (~ 300 g) were divided into four grou
Försök att beskriva och rekonstruera omständigheterna kring Carl Johan Tornbergs (1807-1877) utnämning till och installation som professor i österländska språk 1850.
Background: Skin pain is a common symptom in patients with chronic hand eczema (CHE); however, its association with increased analgesic use has not been thoroughly investigated. Objectives: To examine analgesic use (paracetamol, nonsteroidal anti-inflammatory drugs [NSAIDs], opioids and gabapentin/pregabalin) among patients with CHE compared to a control group. Methods: Data were obtained from the
