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Primär hyperparathyroidism, pHPT, är en relativt vanlig endokrinologisk sjukdom som karaktäriseras av förhöjd utsöndring av bisköldkörtelhormon, PTH, i förhållande till kalciumnivån i blodet. Sjukdomen är vanligast hos äldre och kvinnor, och orsakas oftast av en godartad tumör i en bisköldkörtel (80–85% av fallen) eller mer diffus förstoring av flera bisköldkörtlar. Bisköldkörtlarnas fysiologiska
Melanoma is an aggressive disease that arises from deregulated signaling events in melanocytes. The KIT receptor tyrosine kinase and the Microphthalmia-associated transcription factor (MITF) are two essential components that are required for the normal physiology of melanocyte development and function. Consequently, aberrant activities of these factors are involved in the development of melanoma.
The use of genetically modifi ed neural stem and progenitor cells could possibly be a future strategy for repairing a brain suffering from neurodegeneration. However, so far it has proven diffi cult to maintain sufficient levels of a transferred gene in suitable cell types, after transplantation. In the present thesis I studied the silencing of transgenes induced upon differentiation of neural pro
Popular Abstract in Swedish Som en blixt från klar himmel drabbas en ung, och till synes frisk person, av hjärnblödning. Denna stroke leder till demens och efterföljande nya blödningar leder slutligen till en för tidig död. Man har kunnat visa att denna sjukdom beror på att en variant av ett visst protein, cystatin C, tvinnar ihop sig till rep-liknande långa fibriller. Dessa fibriller ansamlas sedAmyloidosis is a group of diseases characterized by a change in protein conformation resulting in aggregation and tissue deposition of amyloid fibrils. One variant of cystatin C, L68Q cystatin C, is highly amyloidogenic and persons carrying the corresponding gene suffer from massive cerebral amyloidosis leading to brain hemorrhage and death. Amyloidogenic proteins like cystatin C and prion protein
Undersökning av näthinneceller odlade på ljuskänsliga nanotrådar Människans sinnen bombarderas ständigt med nya intryck. En stor del av dessa förmedlas via vår syn. Ljus kommer in i ögat och absorberas av ljuskänsliga fotopigment som finns i de yttre segmenten av näthinnans fotoreceptorer. Näthinnan är uppbyggd av flera olika skikt och av flera olika celltyper, både nervceller och stödjande gliacWorldwide, millions of people suffer from retinal degenerative diseases leading to cell death of light absorbing photoreceptors. This results in vision impairment and, in many cases, eventually blindness. A possible solution for patients gone legally blind due to retinal degeneration, is the use of retinal implants. The best performing retinal implants of today, regarding vision acuity, still give
Malaria är en sjukdom som orsakas av parasiter av plasmodium släktet och överförs mellan människor av myggor. Då myggan biter en malariasmittad människa och förtär dess blod så innehåller detta blod parasiter som i senare sprids ifrån myggans mage och vidare till dess salivkörtlar. När myggan vid ett senare tillfälle biter en frisk människa, överförs parasiten från salivkörtlarna till människans bMalaria is a massive global health crisis that is most prevalent in tropical regions of Africa, Asia, and Latin America. The World Health Organization (WHO) estimated in 2013 that 3.3 billion people were at risk of being infected by the disease, resulting in around 200 million cases with more than 500 000 of these cases leading to lethal outcome. Africa was by far the most affected by the disease
Generalist parasites experience selective pressures from the various host species they infect. However, it is unclear if parasite transmission among host species precludes the establishment of host-specific adaptations and population genetic structure. We assessed the population genetic structure of the vector-transmitted avian haemosporidian parasite Haemoproteus majoris (lineage WW2; n = 34 infe
Bakgrund: I bygg- och anläggningsbranschen skedde 1470 olyckor år 2018 där några även ledde till dödlig utgång (Arbetsmiljöverket, 2018). Utbildningen till maskinförare idag är både lång men grundlig och ger maskinföraren de förutsättningar som krävs för att framföra ett anläggningsfordon på ett säkert sätt på en byggarbetsplats. Genom regleringar från arbetsmiljöverket och förebyggande åtgärder aBackground: In the construction industry a total 1470 accidents occurred 2018 where some of them also led to fatal outcome (Arbetsmiljöverket, 2018). The qualification to be a construction machine operator are both long and thorough and will give the operator the prerequisites to convey the construction machine in a safe way on different construction sites. Through regulations from Arbetsmiljöverk
Hybrid is what we call meetings, seminars or lectures that have both physical and digital participants. It might be the case that a majority of students attend a lecture on site and a few students attend from home – or vice versa. Hybrid teaching has become a relatively common format at University but it comes with several challenges. Therefore, it’s important to think through a meeting in advance
https://www.campusonline.lu.se/en/studying-digitally/manners-and-etiquette-hybrid-teaching - 2026-05-29
In silico tools for splicing defect prediction have a key role to assess the impact of variants of uncertain significance. Our aim was to evaluate the performance of a set of commonly used splicing in silico tools comparing the predictions against RNA in vitro results. This was done for natural splice sites of clinically relevant genes in hereditary breast/ovarian cancer (HBOC) and Lynch syndrome.
There are many projects in Mozambique for poverty reduction. One of these projects is funded by Millennium Challenge Account (MCA) and is aimed to install a total of 600 rural water points in the provinces of Nampula and Cabo Delgado. Each water point consists of a drilled well, a water pump and a communal washing basin. Vertical Electrical Sounding (VES) was used for assessing the uitability of
Fourteen tree-ring chronologies developed from 788 peatland Scots pines sampled at sites in Estonia, Belarus and Sweden were compared for common growth trends and possible links to regional climate dynamics. Several synchronous growth release events were detected, especially during the 1910s, 1930s, and around 1970 and 1990, indicating that hydrological shifts and associated tree growth responses
Endogenous programs that regulate annual cycles have been shown for many taxa, including protists, arthropods, fish, mammals and birds. In migration biology, these programs are best known in songbirds. The majority of songbirds rely on a genetic program inherited from their parents that will guide them during their first solo-migration. The phenotypic components of the program are crucial for thei
In this thesis, the GW approximation (GWA, Green's function G times screened interaction W) and the Hubbard I approximation (HIA) are combined in a non-self-consistent one-shot calculation to determine the electronic structure of a one-dimensional strongly-correlated model. The scheme was chosen to incorporate both screening effects through the GWA and strong on-site correlations through the a
With their highly sensitive visual systems, the arthropods have evolved a remarkable capacity to orient and navigate at night. Whereas some navigate under the open sky, and take full advantage of the celestial cues available there, others navigate in more difficult conditions, such as through the dense understory of a tropical rainforest. Four major classes of orientation are performed by arthropo
OrdförandeMargaretha Grind BundyMed dr. FRSM, FRCPM (distinction)Leg läkare. Specialistkompetens inom invärtes medicin disputerade 1978 med en av avhandling om ett vätskeutdrivande läkemedelsfarmakokinetik och farmkodynamik på Serafimerlasartettet, Karolinska Institutet. Mellan åren 1980 och 2009 arbetade hon inom Astra Zeneca-gruppen som medicinskt ansvarig för Fas 1- IV prövningar inom Astra Ze
https://www.medicin.lu.se/samverkan/stiftelser/bundy-academy/bundy-academys-styrelse - 2026-05-29
Samtliga studenthem som som slog upp portarna i Lund i slutet av 1800-talet var enbart avsedda för män. I början av 1900-talet startades dock ett första studenthem för kvinnor i mycket blygsam skala. Ekonomin satte käppar i hjulet för större satsningar, varpå det dröjde ända till 1937 innan Studentskegården kunde invigas. I Lund runt sekelskiftet 1900 rådde det egentligen ingen brist på studentrum
https://www.kvinnor150.lu.se/lang-vag-mot-varaktigt-hem-kvinnliga-studenter - 2026-05-29
TEMPLATE 3 – OTM-R Checklist Case number: 2019SE450153 Name Organisation under review: Lund University Organisation’s contact details: Gunilla Thylander, HR Department, Lund University (gunilla.thylander@hr.lu.se ), +46 46 222 1503 SUBMISSION DATE: JUNE 18TH 2020 DATE ENDORSEMENT CHARTER AND CODE: September 26th 2019 OTM-R Checklist A specific self-assessment checklist is provided for Open, Transp
https://www.lu.se/sites/www.lu.se/files/template_3-otm-r_checklist_lund_university.pdf - 2026-05-30
The study investigates how the Best Interests of the Child principle in the UN Children's Rights Convention (Article 3) has been adapted in custody disputes in Egypt, Sweden, and Uzbekistan. Although the Convention on the Rights of the Child offers a common normative benchmark, divergent legal cultures shape its domestic meaning: Egypt is governed by religious and state legal norms intersecting wi
Summary: The Fracture Liaison Service (FLS) Consensus Meeting endorsed by the International Osteoporosis Foundation (IOF), Asian Federation of Osteoporosis Societies (AFOS), and Asia Pacific Osteoporosis Foundation (APOF) was hosted by the Taiwanese Osteoporosis Association on October 14, 2017. International and domestic experts reviewed the 13 Best Practice Framework (BPF) standards and concluded
