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Leukotriene A(4) hydrolase - Identification of a common carboxylate recognition site for the epoxide hydrolase and aminopeptidase substrates

Leukotriene ( LT) A(4) hydrolase is a bifunctional zinc metalloenzyme, which converts LTA(4) into the neutrophil chemoattractant LTB4 and also exhibits an anion-dependent aminopeptidase activity. In the x-ray crystal structure of LTA(4) hydrolase, Arg(563) and Lys(565) are found at the entrance of the active center. Here we report that replacement of Arg(563), but not Lys(565), leads to complete a

Comparing Scots pine tree-ring proxies and detrending methods among sites in Jamtland, west-central Scandinavia

Scots pine tree-ring width (TRW) data from Jamtland in the Central Scandinavian Mountains has been used to reconstruct summer temperatures back to 1630 BC. However, it was recently shown that this reconstruction was of limited spatial importance. In this paper, we aim to explain this limitation in the TRW data as a temperature proxy, as well as assess the temperature information from new maximum l

Accurate calculations of geometries and singlet-triplet energy differences for active-site models of [NiFe] hydrogenase

Modelling changes in forest soil chemistry at 16 Swedish coniferous forest sites following deposition reduction

Sites and the mental landscape : Stone Age in the Kullen district, North-western Scania, Sweden

Source apportionment of the summer time carbonaceous aerosol at Nordic rural background sites

Localization of CGRP Receptor Components, CGRP, and Receptor Binding Sites in Human and Rhesus Cerebellar Cortex.

The cerebellum is classically considered to be mainly involved in motor processing, but studies have suggested several other functions, including pain processing. Calcitonin-gene-related peptide (CGRP) is a neuropeptide involved in migraine pathology, where there is elevated release of CGRP during migraine attacks and CGRP receptor antagonists have antimigraine efficacy. In the present study, we e

Port-site metastases following robot-assisted laparoscopic surgery for gynecological malignancies.

Delayed colonisation of arable fields by spring breeding ground beetles (Coleoptera: Carabidae) in landscapes with a high availability of hibernation sites

Risk of hepatocellular carcinoma and cancers at other sites among patients diagnosed with chronic hepatitis B virus infection in Sweden.

Semiempirical modeling of abiotic and biotic factors controlling ecosystem respiration across eddy covariance sites

Surgical site infections in dermatologic surgery: etiology, pathogenesis, and current preventative measures.

Nocturnal body temperature in wintering blue tits is affected by roost-site temperature and body reserves.

Tumor Targeting Using Affibody Molecules: Interplay of Affinity, Target Expression Level, and Binding Site Composition.

Connectivity in Reed Warblers Acrocephalus scirpaceus between breeding grounds in Europe and autumn stopover sites in Iberia

Mechanistic Basis of Branch-Site Selection in Filamentous Bacteria

Suppression of HPV-16 late L1 5'-splice site SD3632 by binding of hnRNP D proteins and hnRNP A2/B1 to upstream AUAGUA RNA motifs.

Direct Site-Directed Photocoupling of Proteins onto Surfaces Coated with beta-Cyclodextrins

Quantitative assessment of the antiviral potencies of 21 shRNA vectors targeting conserved, including structured, hepatitis B virus sites

Multiproxy analysis of a new terrestrial and a marine Cretaceous-Paleogene (K-Pg) boundary site from New Zealand