Search results

Dynamics of Aromatic Side Chains in the Active Site of FKBP12

The carboxin-binding site on Paracoccus denitrificans succinate:quinone reductase identified by mutation and structure comparison

Succinate:quinone reductase catalyzes electron transfer from succinate to quinone in aerobic respiration. Carboxin is a specific inhibitor of this enzyme from several different organisms. We have isolated mutant strains of the bacterium Paracoccus denitrificans that are resistant to carboxin due to mutations in the succinate:quinone reductase. The mutations identify two amino acid residues, His228

Site-selective ¹³C labeling of histidine and tryptophan using ribose

Ischemia-induced upregulation of excitatory amino acid transport sites

Return to Antikythera : Multi-Session SLAM based AUV mapping of a first century BC wreck site

This paper describes an expedition to map a first century B.C. ship wreck off the coast of the Greek island of Antikythera using an Autonomous Underwater Vehicle (AUV) equipped with a high-resolution stereo imaging system. The wreck, first discovered in 1900, has yielded a wealth of important historical artefacts from two previous interventions, including the renowned Antikythera mechanism. The de

The Solution Structures of Mutant Calbindin D_9k's, As Determined by NMR, Show That the Calcium-Binding Site Can Adopt Different Folds

Effect of exchange of the cysteine molybdenum ligand with selenocysteine on the structure and function of the active site in human sulfite oxidase

Identification of an endothelial cell binding site on kininogen domain D3

Shortcomings in current practices for decision-making process and contaminated sites remediation

Heterogeneity of benzodiazepine receptor interactions with γ-aminobutyric acid and barbiturate receptor sites

Perturbation of benzodiazepine receptor binding by pyrazolopyridines involves picrotoxinin/barbiturate receptor sites

Dihydropicrotoxinin binding sites in mammalian brain : Interaction with convulsant and depressant benzodiazepines

The specific binding of [3H]α-dihydropicrotoxinin to rat brain membranes was inhibited competitively and potently (IC50 ≅ 100 nM) by a convulsant benzodiazepine drug, RO5-3663. This compound did not inhibit high affinity flunitrazepam binding to the same tissue under similar conditions, and its reported pharmacological activity as an antagonist of GABAergic synaptic transmission, which resembles t

Barbiturate receptor sites are coupled to benzodiazepine receptors

Picrotoxin and convulsant binding sites in mammalian brain

A Human IgE Antibody Binding Site on Der p 2 for the Design of a Recombinant Allergen for Immunotherapy

Large-Scale Crystallographic Fragment Screening Expedites Compound Optimization and Identifies Putative Protein-Protein Interaction Sites

The identification of starting points for compound development is one of the key steps in early-stage drug discovery. Information-rich techniques such as crystallographic fragment screening can potentially increase the efficiency of this step by providing the structural information of the binding mode of the ligands in addition to the mere binding information. Here, we present the crystallographic

Introduction: Stuckness and Sites of Confinement

Multi-site interactions : Understanding the offsite impacts of land use change on the use and supply of ecosystem services

Cs₃Cu₄In₂Cl₁₃ Nanocrystals : A Perovskite-Related Structure with Inorganic Clusters at A Sites

An effort to synthesize the Cu(I) variant of a lead-free double perovskite isostructural with Cs2AgInCl6 resulted in the formation of Cs3Cu4In2Cl13 nanocrystals with an unusual structure, as revealed by single-nanocrystal three-dimensional electron diffraction. These nanocrystals adopt a A2BX6 structure (K2PtCl6 type, termed vacancy ordered perovskite) with tetrahedrally coordinated Cu(I) ions. In

Climate–ecosystem modelling made easy : The Land Sites Platform

Dynamic Global Vegetation Models (DGVMs) provide a state-of-the-art process-based approach to study the complex interplay between vegetation and its physical environment. For example, they help to predict how terrestrial plants interact with climate, soils, disturbance and competition for resources. We argue that there is untapped potential for the use of DGVMs in ecological and ecophysiological r