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Liquid biopsy allows assessment of multiple analytes, providing temporal information with potential for improving understanding of cancer evolution and clinical management of patients. Although liquid biopsies are intensely investigated for prediction and response monitoring, preanalytic variables are of primary concern for clinical implementation, including categories of collection method and sam
PURPOSE: To analyze the incidence, risk factors, and outcomes of cataract surgery complicated by a dropped nucleus. SETTING: Patients who have received cataract surgery in 18 European countries. DESIGN: Retrospective cross-sectional register-based study. METHODS: Data from the European Registry of Quality Outcomes for Cataract and Refractive Surgery (EUREQUO) were analyzed. The EUREQUO contains pr
The history of Christianity is marked by frequent debates over doctrinal truth. From an early stage, Christian authors began to use the terms "orthodoxy" and "heresy" to deal with diversity of faith. While the orthodox faith was seen as the one that had been preserved from the time of the apostles, heresies were seen as later innovations. This idea was expressed in the Ecclesiastical History by Eu
We consider the pebble game on DAGs with bounded fan-in introduced in [Paterson and Hewitt '70] and the reversible version of this game in [Bennett '89], and study the question of how hard it is to decide exactly or approximately the number of pebbles needed for a given DAG in these games. We prove that the problem of deciding whether s pebbles suffice to reversibly pebble a DAG G is PSPACE-comple
One of the key challenges for nuclear physics today is to understand from first principles the effective interaction between hadrons with different quark content. First successes have been achieved using techniques that solve the dynamics of quarks and gluons on discrete space-time lattices1,2. Experimentally, the dynamics of the strong interaction have been studied by scattering hadrons off each
The genus Eois Hübner (Geometridae: Larentiinae) comprises 254 valid species. Being a hyperdiverse genus, Eois potentially includes many undescribed cryptic species and embodies a problematic taxonomic scenario. The actual diversity of Eois is greatly underestimated and the Neotropical fauna needs to be well known since it figures as one of the most threatened terrestrial ecosystem. In the present
Aim: To assess experience of care, well-being of parents and children's development in a cohort of extremely premature infants born <24 weeks of gestation in Sweden from 2007 to 2018. Methods: A survey based on multiple questionnaires answered by 124/349 (35.5%) parents. Results: The median age of parents and children was 43 and 9 years, respectively; 74.2% were mothers. Parents expressed high hea
Background: Even though children after tonsil surgery experience pain and other limitations in their daily lives, nursing care is transferred to parents after tonsil surgery, and they might need some kind of support. The aim of the study was to test the design of a randomized controlled trial intended to evaluate a nurse-led telephone follow-up after tonsil surgery on postoperative symptoms and qu
Observational studies have revealed that ischemic heart disease (IHD) has a unique manifestation on electrocardiographic (ECG). However, the genetic relationships between IHD and ECG remain unclear. We took 12-lead ECG as phenotypes to conduct genome-wide association studies (GWAS) for 41,960 samples from UK-Biobank (UKB). By leveraging large-scale GWAS summary of ECG and IHD (downloaded from Finn
This work investigates the effects of atmospheric-pressure nanosecond (ns) pulsed plasma discharges on NH3/air flames using optical emission spectroscopy (OES). Firstly, spatially-resolved OES in the 200–800 nm range of NH3/air flames with and without discharges are presented to identify the plasma-induced excited species (such as N2* and H*). Then, time-resolved OES with ns timescale resolution a
Delayed cerebral ischemia (DCI) occurs in up to one third of patients suffering from aneurysmal subarachnoid hemorrhage (aSAH). Untreated, it leads to secondary cerebral infarctions and is frequently associated with death or severe disability. After aneurysm rupture, erythrocytes in the subarachnoid space lyse and liberate free hemoglobin (Hb), a key driver for the development of DCI. Hemoglobin i
Purpose: Currently, foresight studies have been adapted to incorporate new techniques based on big data and machine learning (BDML), which has led to new approaches and conceptual changes regarding uncertainty and how to prospect future. The purpose of this study is to explore the effects of BDML on foresight practice and on conceptual changes in uncertainty.Design/methodology/approach: The method
The study provides a new assessment of the water balance components of the catchment (evapotranspiration, surface and lateral flow etc., and its spatial distribution and temporal variability) for the transboundary catchment of Western Dvina river within the poorly gaged Russian part of the catchment. The study focuses on modeling the inland flow generation processes using open source data and the
Objectives To compile a battery of test including various aspects of physical fitness that could be used on the field and to assess whether any of these tests are associated with future traumatic knee injuries in youth female team sports athletes. Design Prospective cohort. Setting Sport setting. Participants Female athletes (n = 117, age 15–19 years), from Swedish sport high schools, active in so
The benefits of medical devices are often multifaceted and may have an important impact on patients’ and relatives’ physical, mental and/or social well-being. Diabetes is a metabolic disorder and a continuous subcutaneous glucose monitoring sensor can suggest increasing treatment satisfaction. The purpose of this study was to describe parents’ experiences during their daily lives and support needs
Coherent X-ray imaging techniques, such as in-line holography, exploit the high brilliance provided by diffraction-limited storage rings to perform imaging sensitive to the electron density through contrast due to the phase shift, rather than conventional attenuation contrast. Thus, coherent X-ray imaging techniques enable high-sensitivity and low-dose imaging, especially for low-atomic-number (Z)
Background: Laryngoscopy is a difficult skill to acquire and maintain and even more so by less frequent users. Numerous studies have compared limitations of direct laryngoscopic (DL) and video-assisted laryngoscopic (VL) techniques for endotracheal intubation in different scenarios, but individual retention over time of intubation skills with either technique has, to our knowledge, never been repo
The COVID-19 pandemic and its impact on society has been suspected to affect gambling behaviors. Potentially, the pandemic crisis may result in increased problem gambling, for example, due to COVID-19-related psychological distress, unemployment, and financial difficulties. In ad-dition, the cancellation of sports in early parts of the crisis has been suspected to alter gambling behaviors. Policy
