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Concentrations of inorganic elements in 20 municipal waters in Sweden before and after treatment - links to human health

The water chemistry of 20 municipal water treatment plants in southern Sweden, representing various bedrock situations, and water qualities, were investigated. Four water samples, raw and treated. were collected from each plant and analyzed by predominantly ICP-OES and ICP-MS at four occasions from June to December, 2001. The concentrations of Ca, Mg. K.. Na, HCO3 and a number of micronutrients, v

Elevated Lp-PLA2 Levels Add Prognostic Information to The Metabolic Syndrome on Incidence of Cardiovascular Events Among Middle-Aged Nondiabetic Subjects.

Background-To explore potential interrelationships between lipoprotein-associated phosholipase A2 (Lp-PLA(2)), the metabolic syndrome (MetS), and incident cardiovascular disease (CVD). Methods and Results-MetS was defined by the National Cholesterol Education Program Adult treatment Panel III criteria in 4480 nondiabetic Malmo Diet and Cancer Study subjects without history of CVD. Incidence of fir

Radionuclide Production with PET Cyclotrons, Applications and Preclinical Experiments

Popular Abstract in Swedish Nuklearmedicin bygger på användning av radioaktiva spårämnen, enligt principen av George de Hevesy, för kartläggning av global och regional funktion hos organ eller patologisk vävnad. Nuklearmedicin inkluderar även användningen av ”Magic bullet”-konceptet enligt Ehrlich där en molekyl används som bärare av radionuklider för att få en radiobiologisk terepeutisk effekt påNuclear medicine is based on the radiotracer principle of George de Hevesy and the magic bullet concept by Ehrlich and focuses on the diagnosis, the treatment of diseases and the investigation of normal states within the human body using radiopharmaceuticals. A radiopharmaceutical is an atom or a chemical compound in which one or several atoms are replaced with a radionuclide. Several diagnostic a

Inhibition of WNT5A Signaling and Function in Malignant Melanoma

Popular Abstract in Swedish Hudcancerformen malignt melanom är en utav de cancerformer som är på starkast frammarsch idag, där runt 200,000 människor drabbas varje år runt om i världen. Sjukdomen uppkommer p.g.a. förändringar i arvsmassan (DNA) hos en speciell typ av celler som finns i huden, de så kallade melanocyterna. Under normala förhållanden har dessa celler till uppgift att producera det brThe life-threatening disease of malignant melanoma is one of the fastest growing forms of cancer, affecting an estimated number of 200,000 patients worldwide every year. Although highly curable if detected early, once the melanoma has metastasized there are few treatment options and a median survival rate of only 6-9 months. Consequently, there is an imperative need to identify the factors that dr

Consensus Pathways Implicated in Prognosis of Colorectal Cancer Identified Through Systematic Enrichment Analysis of Gene Expression Profiling Studies

Background: A large number of gene expression profiling (GEP) studies on prognosis of colorectal cancer (CRC) has been performed, but no reliable gene signature for prediction of CRC prognosis has been found. Bioinformatic enrichment tools are a powerful approach to identify biological processes in high-throughput data analysis. Principal Findings: We have for the first time collected the results

The CRIRES search for planets around the lowest-mass stars. I. High-precision near-infrared radial velocities with an ammonia gas cell

Radial velocities measured from near-infrared (NIR) spectra are a potentially powerful tool to search for planets around cool stars and sub-stellar objects. However, no technique currently exists that yields NIR radial velocity precision comparable to that routinely obtained in the visible. We are carrying out an NIR radial velocity planet search program targeting a sample of the lowest-mass M dwa

450K-array analysis of chronic lymphocytic leukemia cells reveals global DNA methylation to be relatively stable over time and similar in resting and proliferative compartments

In chronic lymphocytic leukemia (CLL), the microenvironment influences gene expression patterns; however, knowledge is limited regarding the extent to which methylation changes with time and exposure to specific microenvironments. Using high-resolution 450K arrays, we provide the most comprehensive DNA methylation study of CLL to date, analyzing paired diagnostic/follow-up samples from IGHV-mutate

Relationship between distal radius fracture malunion and arm-related disability: A prospective population-based cohort study with 1-year follow-up

Background: Distal radius fracture is a common injury and may result in substantial dysfunction and pain. The purpose was to investigate the relationship between distal radius fracture malunion and arm-related disability. Methods: The prospective population-based cohort study included 143 consecutive patients above 18 years with an acute distal radius fracture treated with closed reduction and eit

Gestational age at birth and risk of testicular cancer

Most testicular germ cell tumors originate from carcinoma in situ cells in fetal life, possibly related to sex hormone imbalances in early pregnancy. Previous studies of association between gestational age at birth and testicular cancer have yielded discrepant results and have not examined extreme preterm birth. Our objective was to determine whether low gestational age at birth is independently a

Survival benefit of lung transplantation in individuals with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema.

BACKGROUND: The objective of lung transplantation (LTx) is to prolong life, but the survival benefit for patients with severe α(1)-anti-trypsin deficiency (PiZZ) and emphysema is still unclear. The aim of this study was to assess whether PiZZ patients who have undergone lung transplantation (the lung transplant group, TxG) do better than patients who have continued on the usual medical therapy (th

Current activities in the ICRP concerning estimation of radiation doses to patients from radiopharmaceuticals for diagnostic use

A Task Group within the ICRP Committees 2 and 3 is continuously working to improve absorbed dose estimates to patients investigated with radiopharmaceuticals. The work deals with reviews of the literature, initiation of new or complementary studies of the biokinetics of a compound and dose estimates. Absorbed dose calculations for organs and tissues have up to now been carried out using the MIRD f

Adverse Effects of Smoking on Peak Bone Mass May Be Attenuated by Higher Body Mass Index in Young Female Smokers.

Smoking is associated with postmenopausal bone loss and fracture, but the effect of smoking on bone in younger women is unclear. Peak bone mass is an important determinant for fracture risk; therefore, our aim was to evaluate the association between smoking and bone mass in 25-year-old women, specifically the influence of daily cigarette consumption and total exposure, duration, age at starting sm

Experimental Validation Of Finite Element Model For Proximal Composite Femur Using Optical Measurements

Patient-specific finite element models have been used to predict femur strength and fracture risk in individuals. Validation of the adopted finite element modelling procedure against mechanical testing data is a crucial step when aiming for clinical applications. The majority of the works available in literature used data from strain gages to validate the model, thus having up to 15 experimental

Prophylactic treatment with proton pump inhibitors in children operated on for oesophageal atresia.

Introduction Oesophageal stricture is a frequent complication following repair of oesophageal atresia (EA). The aim of this study was to conduct a pre- and postintervention study and analyze the incidence of stricture formation and need for balloon dilatation after introducing prophylactic proton pump inhibitor (PPI) treatment.Children and Design All children operated for EA during 2001 to 2009 (n

Intensive therapy for multiple myeloma in patients younger than 60 years. Long-term results focusing on the effect of the degree of response on survival and relapse pattern after transplantation

Background and Objectives. From 1994 to 1997 we conducted a population-based, prospective study on intensive therapy in newly diagnosed symptomatic myeloma patients younger than 60 years, comparing their survival to that of a conventionally treated historic population. Long-term results are presented, including the impact of the degree of response on survival and relapse pattern after transplantat

Vortex-wake interactions of a flapping foil that models animal swimming and flight.

The fluid dynamics of many swimming and flying animals involves the generation and shedding of vortices into the wake. Here we studied the dynamics of similar vortices shed by a simple two-dimensional flapping foil in a soap-film tunnel. The flapping foil models an animal wing, fin or tail in forward locomotion. The vortical flow induced by the foil is correlated to (the resulting) thickness varia

Evaluation of oxalate/oxalic acid for extracting plant available phosphorus in unfertilized acid soils

The extractability of phosphorus (P) was studied in an acid, unfertilized soil at an abandoned farm and in 40 different soils from former agricultural fields and pastures. Oxalate/Oxalic acid extraction was compared with a number of other methods in order to evaluate the suitability of oxalate/oxalic acid as a method for extracting P from soil. The extracting efficiency and a rough estimate of the

Optimal Decisions with Limited Information

Popular Abstract in Swedish Denna avhandling behandlar statiska och dynamiska lagbeslutsproblem i både stokastiska och deterministiska ramverk. Lagproblemet är ett kooperativt spel, där ett antal spelare utgör ett lag som försöker optimera en given kostnad inducerad av omvärldens osäkerhet. Osäkerheten kan modelleras antingen som stokastisk, vilket ger upphov till det stokastiska lag problemet, el

Flow cytometry DNA analysis and prediction of loco-regional recurrences after mastectomy in breast cancer

The study concerns whether DNA flow cytometry and estrogen receptor analysis might help predict which breast cancer patients, particularly node-positive ones, were at the greatest risk of developing loco-regional recurrence (LRR). Such patients would best benefit from postoperative radiotherapy following modified radical mastectomy and axillary lymph node dissection. After this type of surgery, 50

Fungal diversity in set-aide agricultural soil investigated using terminal-restriction fragment length polymorphism

As part of the restoration of biodiversity on former agricultural land there has been focused on methods to enhance the rate of transition from agricultural land towards natural grasslands or forest ecosystems. Management practices such as sowing seed mixtures and inoculating soil of later successional stages have been used. The aim of this study was to determine the effects of a managed plant com