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Protein MIG, from Streptococcus dysgalactiae, binds alpha2-macroglobulin and immunoglobulin G (IgG). MIG-derived fusion proteins with one to five IgG-binding repeats differed up to 72,000- fold in avidity for goat IgG, indicating a considerable cooperativity of the repeats. Significant sequence variation in the IgG-binding repeats was recognized. Protein MIG interacted with goat IgG1 via both the
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In the field of operations and supply chain management (OSCM), the customer order decoupling point (CODP) hasbeen recognized as an important strategic parameter for roughly 30 years. It is the point in the value chain whereforecast-driven material flows get separated from order-driven material flows. Despite its long history in the field,multiple calls for further consideration of the CODP in OSCM