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Cellular redox state is an important metabolic variable, influencing many aspects of cell function like growth, apoptosis, and reductive biosynthesis. In this report, we identify NADPH as a candidate signaling molecule for exocytosis in neuroendocrine cells. In pancreatic beta-cells, glucose acutely raised the NADPH-to-NADP(+) ratio and stimulated insulin release in parallel. Furthermore, intracel

With an increasing number of Free Trade Agreements (FTAs) between the European Union (EU) and the Association of Southeast Asian Nations (ASEAN) countries as well as a greater EU focus on human rights in supply chains, analysis of recent and emerging agreements is a valuable gauge. This analysis is based on existing EU agreements with Singapore and Vietnam, as well as ongoing negotiations with Tha

Armlängdsprincipen kan betraktas som en av de mest centrala principerna inom den internationella beskattningsrätten. I OECD:s modellavtal, som ligger till grund för utformningen av bilaterala dubbelbeskattningsavtal, stadgas armlängdsprincipen i artikel 9, den regel som tillåter korrigering av ett företags vinst när interna transaktioner prissatts på ett sätt som inte är armlängdsmässigt. SamtidigThe ALP can be considered one of the most significant principles within international taxation law. It is regulated under article 9 of the OECD MTC, which acts as a model for developing new bilateral tax treaties. According to article 9, the profit of an enterprise may be adjusted if the enterprise has been involved in transactions with an associated enterprise on conditions that are not of an arm

The purpose of this study was to investigate breathing-motion induced interplay effects for stereotactic body radiotherapy (SBRT) of liver tumours treated with flattening-filter free (FFF) volumetric modulated arc therapy (VMAT). Ten patients previously treated with liver SBRT were included in this study. All patients had four-dimensional computed tomography (4DCT) scans acquired prior to treatmen

Even if much is known regarding the effects of internet-delivered cognitive behaviour therapy (ICBT) for depression there are several topics that have not been studied. In this factorial design trial with 197 participants we investigated if clients in ICBT could select treatment modules themselves based on a selection of 15 tailored treatment modules developed for use in ICBT for depression. We co

This paper examines the applicability of three licensing models, compulsory licensing, free licensing and FRAND licensing, to green technology patent pools. Given that green technologies are critical in addressing global environmental challenges and achieving the SDGs, they can be effective in balancing incentives for innovation with wider dissemination of technologies. This study evaluates ea

This thesis provides a comparative analysis on sustainability chapters in free trade agreements (FTA) from the EU and Australia. It then evaluates the implication this comparison has in light of EU-Australia FTA negotiations. In addition to this, the text utilises a funnel approach by examining broader concepts in order to help answer the research question. This includes the definition of free tra