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Prostate-specific antigen (PSA) is a glycoprotein produced by the prostate gland. It occurs in several molecular forms in the blood and assays have been developed to measure free PSA and PSA in complex with alpha-1-antichymotrypsin (PSA-ACT). Higher proportions of free PSA (PSA-F/T) in blood are found in subjects with benign prostatic hyperplasia (BPH) as compared to cancer patients. Utilizing imm
SynopsisLinear free energy relationships based on equilibrium and kinetics measurements, including variable-temperature and high-pressure data, for complex formation reactions and aquations of square-planar palladium(II) complexes are derived and discussed. In particular, data for an extensive series of carboxylic acids of widely different basicities and steric properties, acting as nucleophiles t
Denna rapport redogör över utvecklingsprocessen för ett silikonfritt, läckagetätt lock för matlådan IKEA 365+, för att undvika användandet av en silikonpackning som produkten gör idag. Drivkraften bakom projektet är att silikon är ett mycket energikrävande material att producera, samt är inte i stor skala återvinningsbart idag. Rapporten använder sig av en traditionell produktutvecklingsprocess saThis report elaborates on the development process of a silicone free, leakproof seal for the lid of the IKEA 365+ food storage platform, to alleviate the need for a silicone gasket that is used for the product today. Silicone is undesirable due to the energy intensive production and because it is not recyclable at large scale. The report uses a traditional product development process along with si
Background: Ocrelizumab is a humanized anti-CD20 antibody with increased antibody-dependent cellular cytotoxicity compared with rituximab. This phase I/II study evaluated its safety and efficacy in patients with relapsed/refractory follicular lymphoma (FL) after prior rituximab therapy. Design and methods: Forty-seven patients were treated in three dose cohorts and received eight infusions every 3
A new method to determine the concentration of the free protein S in plasma is described. It is an enzyme-linked ligandsorbent assay (ELSA) which utilises the protein S binding capacity of the natural ligand C4b-binding protein (C4BP) to capture the free protein S from plasma samples. The use of C4BP as ligand in the assay is possible due to the high affinity (Kd = 0.1 nM) of the interaction betwe
The social, environmental, and economic impact of cars in urban areas are a rising concern of the public and policy makers since motorized vehicles have several negative impacts on individual health and climate change. Car free developments have induced positive changes in all three dimensions of sustainability. The development of car free cities, however, often encounters stakeholder adversity. T
Objectives The systemic vasculitides are multiorgan diseases where early diagnosis and treatment can significantly improve outcomes. Robust nomenclature reduces diagnostic delay. However, key aspects of current nomenclature are widely perceived to be out of date, these include disease definitions, classification and diagnostic criteria. Therefore, the aim of the present work was to identify defici
We previously reported that soluble decay-accelerating factor (DAF) and coxsackievirus-adenovirus receptor (CAR) blocked coxsackievirus 133 (CVB3) myocarditis in mice, but only soluble CAR blocked CVB3-mediated pancreatitis. Here, we report that the in vitro mechanisms of viral inhibition by these soluble receptors also differ. Soluble DAF inhibited virus infection through the formation of reversi
The purpose of dynamic asset allocation (DAA) is to overcome the challenge that changing market conditions present to traditional strategic asset allocation by adjusting portfolio weights to take advantage of favorable conditions and reduce potential drawdowns. This article proposes a new approach to DAA that is based on detection of change points without fitting a model with a fixed number of reg
To confirm findings from a previous pilot study in a larger normal cohort and to study first trimester maternal serum levels of cell-free fetal hemoglobin (HbF) and the heme-scavenger α1-microglobulin (A1M) in patients who subsequently developed preeclampsia (PE), furthermore to evaluate these proteins as predictive biochemical markers of PE.
Enzymatic hydrolysis using immobilized lipases for the production of free fatty acids and glycerol is a promising alternative to the current industrial standard. This study investigates a set of hydrolysis reactions catalysed by four different immobilization techniques to increase the knowledge on two-phase systems. The evaluation of how water purity, buffer salts, and water amount affect the reac
An immunological capacitive biosensor for calpastatin was developed, optimized and applied for the analysis of meat extract samples. Anti-calpastatin antibody was immobilized on a gold electrode modified with a self-assembled monolayer of mercaptoundecanoic acid and Protein A from Staphylococcus aureus, and the obtained immunosensor was inserted as the working electrode in an electrochemical cell
In laryngectomized patients a tracheo-esophageal artificial fistula can be used to achieve air flow from the trachea to the esophagus during speech. A one-way plastic valve is often used for the fistula. A free jejunal graft between the trachea and the esophagus can also be used. To avoid aspiration the transplant is attached to the submental area giving the graft a siphon-like shape. We performed
Lägg till titel FÖRSÄTTSSIDA STYRDOKUMENT Kvalitetspolicy för Lunds universitet Typ av styrdokument: Policy Definition av typen av styrdokument: En policy uttrycker ledningens övergripande viljeriktning eller värden som ska beaktas inom det område policyn omfattar och sätter ramarna för ett visst handlande och utgör en stark rekommendation om ett visst handlingssätt. Beslutsfattare: Universitetsst
