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Acute myeloid leukemia (AML) is characterized by a differentiation block leading to accumulation of immature cells. Chromosomal translocations in AML affect transcription factors that are involved in regulation of myeloid differentiation. Aberrant expression of these factors interferes with differentiation events and has a role in the pathogenesis of AML through superactivation or (dominant negati
Att arbeta hemifrån har de senaste åren blivit allt vanligare. Inför framtiden spås att den fysiska, ordinarie arbetsplatsen kommer att bli än mindre viktig och att fler kommer att vilja arbeta på distans helt eller delvis. Ett reviderat EU-direktiv ger dessutom småbarnsföräldrar och anhörigvårdare möjlighet att begära att få arbeta på distans av omsorgsskäl. Arbetsmarknadens parter har sedan längIn recent years working from home has become much more prevalent. It is predicted that the physical, regular workplace will become even less important in the future and that more people will want to work remotely in whole or in part. A revised EU directive gives parents of young children and carers the opportunity to request to work remotely for care reasons. Early on, Sweden’s labour market partn
Målet med projektet var att analysera problem med arbete i kyla i mjölkproduktionsanläggningar vad gäller förekomst, frekvens och skaderisk samt att föreslå åtgärder för förbättringar. Projektet bestod av två delar: Del 1. En fältstudie, som genomfördes dels i Uppsalatrakten, dels i Västerbottens län. Del 2. En enkätstudie, riktad till Lantbrukshälsans medlemmar i norra regionen. Fältstudierna omfThe aim of the project was to analyse problems with cold when working in dairyfarms with respect to prevalence, frequency and risk for injuries and to propose measures for improvements of thermal conditions. The project comprised two parts: a field study and a questionnaire survey. The field studies were performed at seven dairy-farms in the Uppsala region and six dairy-farms in the northern regio
The purpose with this report is twofold. 1) To examine the safety-work in Swedish communities and 2) how progressive changes can be integrated into the present work. The aim is to counsel community risk- and safety work through: - Describing different safety actors involved in the areas of responsibility and cooperation. - Give suggestions on present models to achieve safe communities. - Summari
Cell-free mitochondrial DNA (cf-mtDNA) is a marker of inflammatory disease and a predictor of mortality, but little is known about cf-mtDNA in relation to psychobiology. A systematic review of the literature reveals that blood cf-mtDNA varies in response to common real-world stressors including psychopathology, acute psychological stress, and exercise. Moreover, cf-mtDNA is inducible within minute
In a Swedish sample of persons eligible for disability services and aged 55 years or older in 2012, persons (n = 601) with autism spectrum disorder diagnoses registered in specialist care were identified. Register data concerning diagnoses of other psychiatric disorders, psychiatric care, and psychiatric medication were reviewed. More than 60% had been in contact with psychiatric care. The majorit
The Earth System Science Partnership, which unites all major global change research programmes, declared in 2001 an urgent need to develop "strategies for Earth System management". Yet what such strategies might be, how they could be developed, and how effective, efficient and equitable such strategies would be, remains unspecified. It is apparent that the institutions, organizations and mechanism
Insulin secretion is controlled by the beta cell's metabolic state, and the ability of the secretory granules to undergo exocytosis increases during glucose stimulation in a membrane potential-independent fashion. Here, we demonstrate that exocytosis of insulin-containing secretory granules depends on phosphatidylinositol 4-kinase (PI 4-kinase) activity and that inhibition of this enzyme suppresse
Popular Abstract in Swedish Under det senaste årtiondet har förekomsten av läkemedel i miljön rönt stor uppmärksamhet. Studier har visat att flera läkemedel hittats i sjöar och vattendrag och kan förorsaka negativa effekter hos vattenlevande organismer. Den i särklass största vägen via vilken läkemedel når miljön är avloppsreningsverk. Efter att vi ätit ett läkemedel kommer kroppen också att utsönThis thesis addresses the application of hollow fiber liquid phase microextraction as a simple, efficient and environmentally friendly tool to study the fate of four common anti-inflammatory drugs (ketoprofen, naproxen, diclofenac and ibuprofen) during wastewater treatment. Initial experiments verified that this technique is applicable on aqueous as well as suspensions of solid samples, thus great
Popular Abstract in Swedish Målet med kollektivtrafik är bl a att anordna transportförsörjning för alla samhällsgrupper på ett samhällsekonomiskt effektivt vis. En grupp medborgare är rullstolsburna resenärer, vars speciella förutsättningar ställer särskilda krav på transportsystemets utformning. För att utröna dessa speciella förutsättningar på ett ansvarsfullt sätt, är det viktigt att man anläggEliciting wheelchair-seated passengers’ perspective of safety and comfort is both useful and mandatory, particularly for researchers, clinicians, transit authorities, and for operators during purchase and use of vehicle technologies in existing and planned future transport systems. Therefore, the overarching objective of this thesis was to delineate the question of safety and comfort as perceived
A cluster of metabolic factors have been merged into an entity named the metabolic syndrome. Although the characteristics of this syndrome have varied over time the presently used definition was established in 2009. The presence of three abnormal findings out of five components qualifies a person for the metabolic syndrome: elevated waist circumference, elevated triglycerides, reduced high-density
BACKGROUND: An increasing number of women are evaluated for potential breast cancer and may experience mental distress during evaluation. We aim to assess the risks of psychiatric disorders and cardiovascular diseases during the diagnostic workup of potential breast cancer.METHODS: All women with a new diagnosis of unspecified lump in breast (N = 15,714), benign tumor or breast cancer in situ (N =
Aim: One of the causes for lower cure rates in acute childhood leukemia in low- and middle- income countries (LMIC) compared to high-income countries is abandonment from treatment. The International Society of Pediatric Oncology (SIOP) defines abandonment as failure to begin treatment or an absence of 4 weeks during treatment. The aim of this study was to evaluate the extent of abandonment among p
Autoimmune (type 1) diabetes mellitus is a chronic disease without a cure. It affects primarily young people but may be diagnosed at any age. Strong genetic susceptibility characterizes the most common form of autoimmune diabetes in children younger than 18 years of age. Autoimmune diabetes is generally assumed to be hereditary, although the majority of patients do not have a family history of aut
Background: To expand our clinical and scientific knowledge about holistic outcomes within palliative care, there is a need for agreed-upon patient-reported outcome measures. These patient-reported outcome measures then require translation and cultural adaptation, either from country-specific languages to English, or the other way around. The aim of this study was to translate and cross-culturally
OBJECTIVES: To illuminate patterns observed in International Cancer Benchmarking Programme studies by extending understanding of the various influences on presentation and referral with cancer symptoms.DESIGN: Cross-country comparison of Denmark, England and Sweden with qualitative analysis of in-depth interview accounts of the prediagnostic process in lung or bowel cancer.PARTICIPANTS: 155 women
Most products are developed while adapting to requirements from industrial production and logistics. To break that trend and design for people, we suggest focusing on those who put the strongest demands on the final solution. They cannot compensate for bad design solutions and are thereby, like sniffing dogs, guiding designers to meet peoples’ needs. We always use a combination of empathic modelli
