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A numerical investigation of dimple effects on internal heat transfer enhancement of a double wall cooling structure with jet impingement

Purpose - The dimple is adopted into a double wall cooling structure which is widely used in hot gas components to increase the heat transfer effects with relatively low pressure drop penalty. The purpose of this paper is to study the effect of dimple depth and dimple diameter on the target surface heat transfer and the inlet to outlet friction factor. Design/methodology/approach - The study is ca

Metabolic engineering of Thermoanaerobacterium AK17 for increased ethanol production in seaweed hydrolysate

Sustainably produced renewable biomass has the potential to replace fossil-based feedstocks, for generation of biobased fuels and chemicals of industrial interest, in biorefineries. In this context, seaweeds contain a large fraction of carbohydrates that are a promising source for enzymatic and/or microbial biorefinery conversions. The thermoanaerobe Thermoanaerobacterium AK17 is a versatile ferme

Integration of Specialized Palliative Care with Oncological Treatment in Patients with Advanced Pancreatic Cancer

INTRODUCTION: The incidence of pancreatic cancer is around 5 in 100,000, and the 5-year survival is poor. Pancreatic cancer patients have a high disease-specific burden of symptoms, and palliative chemotherapy has varying side effects. The American Society of Clinical Oncology (ASCO) suggests integrating specialized palliative care (SPC) with standard oncological treatment for pancreatic cancer pa

Intratumoral T-cell and B-cell receptor architecture associates with distinct immune tumor microenvironment features and clinical outcomes of anti-PD-1/L1 immunotherapy

Background Effective cooperation between B-cells and T-cells within the tumor microenvironment may lead to the regression of established tumors. B-cells and T-cells can recognize tumor antigens with exquisite specificity via their receptor complexes. Nevertheless, whether a diverse intratumoral B-cells and T-cell receptor (BCR, TCR) repertoire affects the tumor immune microenvironment (TIME) and c

Randanteckningar om svensk mediepolitik 1920–1970 : Ur temamodellering av 11 000 riksdagsprotokoll

In an explorative manner, this article uses a data-driven digital history set-up to focus on how the Swedish Riksdag, its political parties and parliament members discussed media issues. By distant reading and topic modeling a dataset of more than 11,000 parliamentary minutes – approximately 400 million characters – the article gives a new perspective of Swedish media history in general and nation

Numerical investigations of endwall film cooling design of a turbine vane using four-holes pattern

Purpose: Endwall film cooling protects vane endwall by coolant coverage, especially at the leading edge (LE) region and vane-pressure side (PS) junction region. Strong flow impingement and complex vortexaa structures on the vane endwall cause difficulties for coolant flows to cover properly. This work aims at a full-scale arrangement of film cooling holes on the endwall which improves coolant effi

Blood-based mitochondrial respiratory chain function in major depression

Mitochondrial dysfunction has been implicated in major depressive disorder (MDD). A measure of mitochondrial respiratory chain (RC) enzymatic activity—the Mitochondrial Health Index (MHI)—has previously been found to correlate with stress and emotional states in caregivers. We here report mitochondrial RC activities, mitochondrial DNA copy number (mtDNAcn), and the composite MHI in unmedicated and

Geospatial data integration and visualisation using Linked Data

Geospatial data are increasingly available nowadays, and this leads to more analyses and visualisation of geospatial data from several sources. To enable this, we need homogenous data as well as proper integration methods. Geospatial data integration has been a longstanding research topic for decades, and this paper discusses the utilisation of Linked Data technology stack to alleviate the geospat

Prognostic significance of lymphocyte-activation gene-3 expression in chemoradiotherapy-naïve esophageal and gastric adenocarcinoma

Background: Neoadjuvant and/or adjuvant treatment has led to an improved survival in patients with resectable gastroesophageal adenocarcinoma (GEAC). Nevertheless, survival rates remain poor and, hence, there is a great need to identify novel treatment strategies and relevant complementary diagnostics. Immunotherapies targeting the PD‐1/PD‐L1 checkpoints have shown promising results, but simultane

Body Temperature and Activity Rhythms Under Different Photoperiods in High Arctic Svalbard ptarmigan (Lagopus muta hyperborea)

Organisms use circadian rhythms to anticipate and exploit daily environmental oscillations. While circadian rhythms are of clear importance for inhabitants of tropic and temperate latitudes, its role for permanent residents of the polar regions is less well understood. The high Arctic Svalbard ptarmigan shows behavioral rhythmicity in presence of light-dark cycles but is arrhythmic during the pola

Titmice turn on the central heating

Small birds are hot creatures with an average body temperature of 40° Centigrade, and so must burn energy at a formidable rate to stay warm. This becomes quite the challenge in winter when birds are 40-50 degrees warmer than outside for extended periods, even in comparatively mild regions such as Scotland. Thus, the little bird in winter must spend most of the day either feeding or searching for f

Numerical analysis of radiative heat transfer in an inhomogeneous and non-isothermal combustion system considering H2O/CO2/CO and soot

Purpose - H2O, CO2 and CO are three main species in combustion systems which have high volume fractions. In addition, soot has strong absorption in the infrared band. Thus, H2O, CO2, CO and soot may take important roles in radiative heat transfer. To provide calculations with high accuracy, all of the participating media should be considered non-gray media. Thus, the purpose of this paper is to st

Modelling over-hygroscopic wood sorption isotherms based on quantitative wood anatomy

A sorption isotherm expresses the relation between ambient relative humidity (RH) and equilibrium moisture content of a material for a specific temperature. The sorption isotherm can generally be divided into a hygroscopic part covering low, medium and high RH levels, and an over-hygroscopic part close to 100% RH. For wood, the hygroscopic part is dominated by water uptake in cell walls and the ov

System för rapporterande utvärdering av kurser vid Lunds tekniska högskola

I detta kapitel beskrivs hur man vid Lunds tekniska högskola organiserar kursvärderingar som en del i ett övergripande arbete med rapporterande utvärdering av kurser. Syftet är att bidra med förståelse för hur olika konkreta problem förknippade med genomförandet av ett system för kursvärdering och utvärdering angripits på Lunds tekniska högskola. kapitlet visar också på hur Lunds tekniska högskola

Exploring the Railway System from a Risk Governance Perspective

Popular Abstract in Swedish Olyckor i järnvägssektorn kan ge upphov till katastrofala konsekvenser. I första hand kan människors liv och hälsa drabbas, men allvarliga konsekvenser kan även uppstå för samhället i stort. Detta beror på att järnvägssystemet, liksom en rad andra infrastruktursystem är väsentliga för att vårt moderna samhälle ska fungera. Under de senaste decennierna har dessa system bIn recent decades, the Swedish railway system has faced substantial deregulations. As a result, management of risk is often carried out in settings involving multiple stakeholders having various roles, mandates, and viewpoints on risk, and where no single stakeholder has the superior authority. In order to manage risks in this type of multi-actor setting, the traditional elements of risk assessmen