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IgG glycan hydrolysis by EndoS diminishes the pro-inflammatory properties of immune complexes from patients with SLE - a possible new treatment?

OBJECTIVE.: Systemic lupus erythematosus (SLE) is an autoimmune disease with chronic or episodic inflammation in several organ systems, related to the presence of circulating and tissue-deposited immune complexes (ICs) which stimulate leukocytes through FcγRs with subsequent inflammation. Treatment with EndoS, an IgG glycan hydrolyzing bacterial enzyme from Streptococcus pyogenes, has shown benefi

Den pedagogiska praktikens janusansikte: om det kommunikativa handlandets didaktiska villkor och konsekvenser

Popular Abstract in Swedish Villkoren för utbildning och undervisning förändras i väsentliga avseenden i takt med samhällets tilltagande komplexitet. Det är många gånger svårt för både lärare och elever att veta hur man på bästa sätt ska orientera sitt pedagogiska handlande. Med utgångspunkt från tre pedagogiska kontexter - grundskolan, de särskilda ungdomshemmen och grundskollärarutbildningen - pPedagogical practice is, in several important considerations, contradictory in character. In this dissertation attenention is drawn towards the field of tension that prevails between pedagogical action, which can be descibed in terms of strategic processes and communicative pedagogical action. While the former places the preconditions for effective knowledge development of the individual at the ce

Parents experience a sense of guilt when their newborn is diagnosed small for gestational age, SGA. A grounded theory study in Sweden

Background: To become a parent of a child who is born small for gestational age can lead to challenges in addition to the newly acquired parenting role. There is currently a lack of knowledge regarding parents' experiences of having a child born small for gestational age. Purpose: The purpose of this study was to describe the experience of becoming a parent of a child small for gestational age Des

Effect of divider wall-to-end wall distance on the vortical structures and heat transfer characteristics of two-pass channel using topological analysis

Purpose: This study aims to explore the 3 D separated flow fields and heat transfer characteristics at the end wall of a serpentine channel with various turn clearances using topological analysis and critical points principles of three-dimensional vortex flow. Design/methodology/approach: This aims to explore the 3 D separated flow fields and heat transfer characteristics at the end wall of a serp

Ecoenzymatic stoichiometry can reflect microbial resource limitation, substrate quality, or both in forest soils

Many studies have used the relative activities of extracellular enzymes associated with microbial carbon (C), nitrogen (N) and phosphorus (P) acquisition to infer the relative C vs. nutrient limitation of the microbial community. However, recent experimental and theoretical evidence has shown that the use of ecoenzymatic ratio to infer limiting microbial resources may be invalid. We added the two

Elizabeth Bennet vs Katniss Everdeen

Analys av hjältinnan utifrån ett feministiskt perspektiv. En jämförelse mellan Jane Austens hjältinna Elizabeth Bennet i Pride and Prejudice och Suzanne Collins hjältinna Katniss Everdeen i The Hunger Games.Analysis of the heroine from a feminist perspective. A comparison between Jane Austen's heroine Eliabeth Bennet in Pride and Prejudice and Suzanne Collins' heroine Katniss Everdeen in The Hunger Games.

Från tyst kunskap till handling: En studie om våldsutsatthet hos kvinnor med funktionsnedsättning på LSS-boende

This study aims to examine the challenges and practices of staff working at accommodations regulated by the Swedish Act concerning support and service for persons with certain functional impairments (LSS) when working with women with disabilities who have suffered from violence. Previous research shows that women with disabilities are at a greater risk of being victims of violence. Despite this kn

Gage et al science 1983

Since the fusions are intraspecies, and in many cases involve highly aneuploid lines, it is not possible to perform de- tailed cytogenetic analyses. However, comparisons of total chromosome counts of hybrid clones with those of the parental cell lines indicate varying de- grees of chromosome loss in the hybrids. The median chromosome number in the hybrids from the GM 639 x T98G and GM 639 x GM 639

https://www.wnc.lu.se/sites/wnc.lu.se/files/gage_et_al_science_1983.pdf - 2026-05-19

Forskningen möter fältet : en kartläggning av branschtidskrifternas forskningsbevakning 1994-2002

Library and information science (LIS), is a research area marked by theoretical diversity and strong influence from both the developing library profession, as well as other social sciences. During the development of LIS several attempts have been made to define its scientific identity. The definition of what constitutes core, boundaries and the superior identity of LIS is still debated among resea

A comparison of the Basel III capital requirement models for financial institutions

The purpose of this report is to implement and compare the two Basel III standard methods on how to calculate the capital requirement for finan- cial institutions, related to counterparty credit risk. The models being the Standardized Approach for Counterparty Credit Risk (SA-CCR) and the Internal Model Method (IMM). The SA-CCR model is a simpler and more standardized model with prescribed methods

Between Self-Determination, Consistency and Rights Protection: Process-Based Review in Expulsion Cases under Article 8 of the European Convention on Human Rights

Den här uppsatsen undersöker Europadomstolens praxis gällande utvisningar av personer som har begått brott, som hävdar att deras utvisning strider mot Artikel 8 av Europakonventionen. Uppsatsen undersöker hur domstolen har använt sig av den nationella beslutsprocessens kvalitet som ett argument för att komma fram till sin slutsats i sådana fall. Uppsatsen utgår från premissen att utvisningar som bThis thesis examines the practice of the European Court of Human Rights to decide expulsion cases implicating migrants with criminal record under Article 8 of the European Convention on Human Rights by use of process-based review. It departs from the premise that such expulsions do not violate absolute rights but constitute interferences with a qualified right, which allows for infringements neces

Adverse pregnancy outcomes and long-term risk of stroke : a Swedish nationwide co-sibling study

The lifelong risk of stroke following adverse pregnancy outcomes, and potential causality, are unknown. This study examined five major adverse pregnancy outcomes and long-term risk of stroke in a large population-based cohort. Methods A national cohort study was conducted of all 2 201 393 women with a singleton delivery in Sweden during 1973–2015, followed up for stroke through 2018. Cox regressio

Mental health for primary care professionals : The role and leadership of management and health systems in mental health promotion in working settings

The mental health of the health workforce has been receiving more attention, especially since the pandemic. Levels of burnout, moral injury, and mental disorders, including suicide, among physicians are cause for concern. Healthcare leadership in workplaces plays a crucial role in addressing this important issue, which is also related to the ability to attract and retain physicians. This chapter p

Utveckling av kommunikativ och empatisk förmåga- en studentdriven modell i läkarutbildningen

Bakgrund: God kommunikativ och empatisk förmåga hos läkare skapar trygghet och upplevs som professionellt av patienter och närstående. Forskning visar att empati förbättrar patienters följsamhet, nöjdhet och relationen mellan läkare och patient, vilket i sin tur leder till högre vårdkvalitet, bättre behandlingsresultat och minskade vårdkostnader. Ett empatiskt förhållningssätt främjar både fysisk

Consensus on the management of traumatic brain injury in older adults : Results from a Delphi study

INTRODUCTION: As the world population is rapidly becoming older, the incidence of traumatic brain injury (TBI) is increasing among older adults with vast implications for brain health of older adults in Europe. Due to differences from younger patients, there are areas of uncertainty in the assessment, diagnosis and management of TBI in older adults.RESEARCH QUESTION: To reach a consensus among exp

Interdisciplinary risks–a delicate balance between trust and critical review

We argue that the subject matter and objectives of risk science establish it as an inherently interdisciplinary field, closely connected to both academic disciplines and practical applications. However, risk research faces a range of interdisciplinary challenges. These include the production of low-quality research—characterised by superficial and insufficiently grounded conclusions—a lack of mutu