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Two flow cytometric parameters are generally used to quantify platelet activation as measured by P-selectin (CD62) expression: percentage and mean channel fluorescence of CD62-positive platelets (%+ and MCF+, respectively). We describe a method for calculation of indices of platelet activation for positive (IPA+) and total (IPA(Σ)) platelets, which reflect integrated amounts of CD62 expressed in t

BACKGROUND: The cornerstones in the assessment of emergency department (ED) patients with suspected acute coronary syndrome (ACS) are patient history and physical examination, electrocardiogram, and cardiac troponins. Although there are several prior studies on this subject, they have in some cases produced inconsistent results.OBJECTIVE: The aim of this study was to evaluate the diagnostic and pr

Initial second language acquisition proceeds surprisingly quickly. Foreign words can sometimes be used within minutes after the first exposure. Yet, it is unclear whether such rapid learning also takes place for more complex, multi-layered properties like words with complex morphosyntax and/or tonal features, and whether it is influenced by transfer from the learners’ native language. To address t

BACKGROUND: We investigated the potential associations between cerebro-spinal fluid (CSF) levels of phosphorylated tau (P-tau) and total tau (T-tau) with short-term response to cholinesterase inhibitor (ChEI) treatment, longitudinal outcome and progression rates in Alzheimer's disease (AD). METHODS: This prospective, observational study included 129 participants clinically diagnosed with mild-to-m

A key challenge in the treatment of colorectal cancer is identification of the sentinel draining lymph node. Magnetomotive ultrasound, MMUS, has identified lymph nodes in rat models: superparamagnetic iron oxide nanoparticles (SPIONs) accumulated in the lymph are forced to oscillate by an external magnetic field; the resulting axial displacement is recovered allowing structure delineation with pot

Background: Providing continuous follow-up care to patients with congenital heart disease (CHD) remains a challenge in many settings. Previous studies highlight that patients with CHD experience discontinuation of follow-up care, but mainly describe a single-centre perspective, neglecting inter-institutional variations. Hospital-related factors above and beyond patient-related factors are believed

Background: There is a great variability in licit prescription drug use in the population and among patients. Factors other than purely medical ones have proven to be of importance for the prescribing of licit drugs. For example, individuals with a high age, female gender and low socioeconomic status are more likely to use licit prescription drugs. However, these results have not been adjusted for

Background: Alzheimer’s disease (AD) is a neurodegenerative disorder characterized by tau and amyloid brain pathology. With the gradual degeneration of neurons, cognitive symptoms will arise and the affected individual will eventually develop AD dementia. The neuropathologic hallmarks of AD have been observed also in cognitively healthy individuals, which has led to the assumption that the disorde

The purpose of this study was to determine whether delayed gadolinium-enhanced magnetic resonance imaging of cartilage (dGEMRIC) and T2 mapping are accurate techniques for measuring cartilage thickness in the metacarpus3/metatarsus3 (Mc3/Mt3) of Thoroughbred racehorses. Twenty-four Mc3/Mt3 cadaver specimens were acquired from six healthy racehorses. Cartilage thickness was measured from postintra-

The purpose of this study was to assess the reliability and construct validity of the Spanish version of the 6-item carpal tunnel syndrome (CTS) symptoms scale (CTS-6).

Prostate specific antigen (PSA) is an important biomarker for diagnosis and prognosis of prostate cancer. Herein, microcontact PSA-imprinted surface plasmon resonance (SPR) sensor chip was developed for sensitive, real-time detection of PSA. The imprinted chip was prepared in the presence of methacrylic acid (MAA) as functional monomer and ethylene glycol dimethacrylate (EGDMA) as cross-linker via

Hydroelectric power is a controversial renewable energy. Adding more renewables to the energy mix is becoming more critical with the onslaught of climate change, while river health and water quality remain a highly pertinent environmental issue. Balancing the need for local renewable energy and environmental concerns is the topic of many cases. This thesis analyzes a case of conflict surrounding t

Global dependence on fossil fuels encourages the depletion of non-renewable resources, produces greenhouse gas emissions, and ultimately contributes to anthropogenic climate change. Current efforts do not reduce depletion rates of these non-renewable resources despite collective action to improve long-term sustainability of Norwegian energy governance in the Barents Sea. This study focuses on the

I detta examensarbete analyseras och diskuteras de omfattande förändringar inom rättsområdet grundläggande rättigheter som följt efter att Lissabonfördraget trädde i kraft den 1 december 2009. Arbetet är avgränsat till att beskriva de förändringar som art. 6.1 och art. 6.2 i Fördraget om Europeiska Unionen (FEU) inneburit. Enligt art. 6.1 ska den Europeiska Unionens Stadga om de Grundläggande RättThis thesis analyses and discusses some of the substantial changes brought about for the field of fundamental rights by virtue of the entry into force of the Lisbon Treaty 1 December 2009; Art. 6(1) to the Treaty on European Union (TEU), according to which the Charter of Fundamental Rights of the European Union (CFREU) “shall have the same legal value as the Treaties” and Art. 6(2) TEU according t

Popular science Dissolve organic carbon degradation in the estuarine environment Dissolve Organic Carbon (DOC) is transported to the estuarine systems via river runoff where it is largely degraded by microbial communities. The availability of DOC effects aquatic ecosystems by causing changes in the bioavailability of toxic compounds, and by increasing the acidity of water . DOC degradation causes Terrestrially-derived dissolved organic carbon (DOC) is transported to estuarine systems via river runoff, where it is largely degraded by microbial communities. I studied the combined influence of salinity (NaCl), microbial community (marine vs. freshwater) and inorganic nitrogen (N) and phosphorus (P) availability on DOC degradation rates in 10 major rivers in Sweden sampled during summer. The D

This article examines whether the current UK judicial approach is an adequacy of the judicial approach Rule of law and GAAR and studies the historical experience of Canada with its statutory solutions. Based on the comparative study background, the article considers to a large extent, a statutory general anti-avoidance principle might assist with the problems of statutory interpretation in the Uni