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Objective: To design an economic model describing the costs and outcomes for patients treated with tumour necrosis factor alpha ( TNF alpha) inhibitors for rheumatoid arthritis ( RA) in current clinical practice in Sweden, to be used as a tool to estimate cost- effectiveness of the next generation of treatments. Methods: The model was constructed as a discrete event simulation ( DES) model analyse
Neurofibromatosis is associated with mid-aortic dysplasia, renal artery aneurysms and renal artery ostial stenosis, or occlusions in about 1% of cases. We describe a novel approach to recanalize an occluded renal artery in a 10-year-old girl with neurofibromatosis and difficulty in pharmacologically controlling her hypertension. Normally, when reconstruction is required, an open operative techniqu
Ultrafast time-resolved fluorescence spectroscopy has been used to investigate the excited-state dynamics of the basic eumelanin building block 5,6-dihydroxyindole-2-carboxylic acid (DHICA), its acetylated, methylated, and carboxylic ester derivatives, and two oligomers, a dimer and a trimer in the O-acetylated forms. The results show that (1) excited-state decays are faster for the trimer relativ
Cyclic AMP potentiates glucose-stimulated insulin release and mediates the stimulatory effects of hormones such as glucagon-like peptide 1 (GLP-1) on pancreatic b-cells. By inhibition of cAMP-degrading phosphodiesterase (PDE) and, in particular, selective inhibition of PDE3 activity, stimulatory effects on insulin secretion have been observed. Molecular and functional information on b-cell PDE3 is
Inactivation of factor Va (FVa) by activated protein C (APC) is a key reaction in the down- regulation of thrombin formation. FVa inactivation by APC is correlated with a loss of FXa cofactor activity as a result of three proteolytic cleavages in the FVa heavy chain at Arg(306), Arg(506), and Arg(679). Recently, we have shown that heparin specifically inhibits the APC- mediated cleavage at Arg(506
Heparan sulfate 3-O-sulfotransferase transfers sulfate to the 3-OH position of a glucosamine residue of heparan sulfate (HS) to form 3-O-sulfated HS. The 3-O-sulfated glucosamine residue contributes to two important biological functions of HS: binding to antithrombin and thereby carrying anticoagulant activity, and binding to herpes simplex viral envelope glycoprotein D to serve as an entry recept
In this paper, which was prepared as part of IEA Bioenergy Task XV (“Greenhouse Gas Balances of Bioenergy Systems”), we outline a standard methodology for comparing the greenhouse gas balances of bioenergy systems with those of fossil energy systems. Emphasis is on a careful definition of system boundaries. The following issues are dealt with in detail: time interval analysed and changes of carbon
So far, the use of epostane, a relatively new inhibitor of 3 beta-hydroxysteroid dehydrogenase/delta 5-delta 4 isomerase enzyme system (3 beta-HSD), has been confined to short-term interference with luteal and placental function. This study explored whether epostane treatment from the beginning of the cycle for approximately 1 month would also inhibit ovarian follicular function. Twenty females wi
Many paleoceanographic reconstructions of the glacial North Atlantic include estimates of iceberg discharge, which are based on the variable abundance of ice-rafted detritus (IRD) in deep-sea sediments. IRD abundance is most often determined by the mechanical separation and painstaking counting of terrigenous particles larger than a specified threshold grain size, typically 150 mum. Here we presen
The Large Hadron Collider (LHC) will be ready for proton-proton collisions in the year 2005 and the ATLAS detector will be one of the two experiments at the LHC which will explore a new and higher energy range for particle physics. In this thesis, an analysis of the power of the ATLAS detector to detect a Standard Model Higgs boson has been performed. It is shown that it will be possible to discov
Popular Abstract in Swedish Bukspottkörteln (pankreas) består av en sekretorisk (exokrin) del, som producerar pankreassaft innehållande olika matspjälkningsenzymer vilka medverkar vid nedbrytningen av födan i tarmen, samt en hormoninsöndrande (endokrin) del, som producerar insulin och andra hormon vilka reglerar näringsomsättningen i kroppen. Vid en underproduktion av enzymer, exokrin pankreatisk Exocrine pancreatic insufficiency (EPI), resulting from disease (e.g. cystic fibrosis, chronic pancreatitis) or surgery (e.g. pancreectomy or pancreas duct ligation), leads to disorders in the digestive system, such as, maldigestion, malabsorption and finally malnutrition. Pancreatic duct-ligated (PDL) pigs have been used as a suitable large-animal model to study the conditions and treatment of EP
Popular Abstract in Swedish Tjugo patienter som deltog i psykiatrisk öppenvård baserad på arbetsterapi undersöktes beträffande behandlingsresultat, uppfattningen om vårdklimatet och upplevelsen av behandlingsrelationen med arbetsterapeuten. Psykiatriska symtom, global mental hälsa, livskvalitet och fungerandet i dagligt liv studerades vid inskrivning i behandlingen, vid utskrivning, samt vid en etThe outcomes of 20 patients participating in occupational group therapy at a psychiatric outpatient unit were explored and related to perceptions of the ward atmosphere and the treatment process. The outcome variables - psychiatric symptoms, global mental health, quality of life, and occupational functioning - were measured at admission, at discharge, and 1 year after discharge. The ward atmospher
We report on charged hadron production in deuteron-gold reactions at roots(NN) = 200 GeV. Our measurements in the deuteron direction cover 1.4
AIMS: To examine the relationships of two screening instruments recently developed for assessment of exhaustion disorder (ED) with some other well-known inventories intended to assess ED-related concepts and self-reports of job demands, job control, job support, private life stressors, and personality factors.METHODS: A cross-sectional population sample ( n = 1355) completed: the Karolinska Exhaus
Sustained international diplomatic efforts culminated in the signing of the Paris Climate Agreement by 196 countries in December 2015. This paper provides an overview of the key provisions of the agreement that are most relevant to the tourism sector: much strengthened and world-wide participation in greenhouse gas emission reduction ambitions, an enduring framework for increased ambitions over ti
Forests used for timber production provide essential ecosystem services to society, as well as potential breeding habitat for bird communities. In southern Sweden, 90% of productive forest land is used for timber production and stands dominated by Norway spruce (Picea abies) constitute approximately 40% of the forested area. Due to their homogeneous structure, these spruce production forests are o
Solar cells made from inorganic-organic perovskites have gradually approached market requirements as their efficiency and stability have improved tremendously in recent years. Planar low-temperature processed perovskite solar cells are advantageous for possible large-scale production but are more prone to exhibiting photocurrent hysteresis, especially in the regular n-i-p structure. Here, a system
Satellite remote sensing of plant phenology provides an important indicator of climate change. However, start of the growing season (SOS) estimates in Northern Hemisphere boreal forest areas are known to be challenged by the presence of seasonal snow cover and limited seasonality in the greenness signal for evergreen needleleaf forests, which can both bias and impede trend estimates of SOS. The ne
Linkage between behavioral states and neural activity is one of the most important challenges in neuroscience. The network activity patterns in the awake resting state and in the actively behaving state in rodents are not well understood, and a better tool for differentiating these states can provide insights on healthy brain functions and its alteration with disease. Therefore, we simultaneously
