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Structural determination of Streptococcus pyogenes M1 protein interactions with human immunoglobulin G using integrative structural biology

Streptococcus pyogenes (Group A streptococcus; GAS) is an important human pathogen responsible for mild to severe, life-threatening infections. GAS expresses a wide range of virulence factors, including the M family proteins. The M proteins allow the bacteria to evade parts of the human immune defenses by triggering the formation of a dense coat of plasma proteins surrounding the bacteria, includi

Efficacy of T-cell assays for the diagnosis of primary defects in cytotoxic lymphocyte exocytosis

Primary hemophagocytic lymphohistiocytosis (HLH) is a life-threatening disorder associated with autosomal recessive variants in genes required for perforin-mediated lymphocyte cytotoxicity. A rapid diagnosis is crucial for successful treatment. Although defective cytotoxic T lymphocyte (CTL) function causes pathogenesis, quantification of natural killer (NK)–cell exocytosis triggered by K562 targe

Group G streptococcal IgG binding molecules FOG and protein G have different impacts on opsonization by C1q

Recent epidemiological data on diseases caused by beta-hemolytic streptococci belonging to Lancefield group C and G ( GCS, GGS) underline that they are an emerging threat to human health. Among various virulence factors expressed by GCS and GGS isolates from human infections, M and M-like proteins are considered important because of their anti-phagocytic activity. In addition, protein G has been i

Streptococcus pyogenes secreted enzymes interacting with the human host

Streptococcus pyogenes is one of the most common bacteria infecting humans. One of the factors contributing to the disease-causing properties is the secreted streptococcal cysteine proteinase, SpeB, which degrades several host proteins in connective tissue and circulation. SpeB activity depends on the transformation from an inactive precursor, zymogen, into a mature proteinase. We show that

Development and validation of a novel Simoa assay for NPTX2 in Alzheimer's disease and Down syndrome

INTRODUCTION: Synaptic dysfunction and loss are pathological hallmarks of neurodegenerative diseases. Neuronal pentraxin 2 (NPTX2), a presynaptic protein involved in synaptic plasticity, has been linked to cognitive decline in Alzheimer's disease (AD) and other neurodegenerative disorders. METHODS: We developed and validated a novel single molecule array (Simoa) for NPTX2 in cerebrospinal fluid, w

Potentialities of manganese ore and iron-carbon particles for pharmaceuticals and personal care products removal in electroactive constructed wetland

This study explores the use of manganese ore, iron-carbon particles (Fe-C), and gravel as anode fillers in electroactive constructed wetlands (ECWs) to treat wastewater containing pharmaceuticals and personal care products (PPCPs) including ciprofloxacin (CIP), ofloxacin (OFL), and naproxen (NPX), while also assessing bioelectricity production. Although the presence of PPCPs reduced pollutant remo

Geop04 schema 2016-03-29

Schema för GEOP04 Miljögeologisk markundersökning, 15 hp VT2 2016 Kursansvariga: Håkan Rosqvist hakan.rosqvist@tyrens.se, Per Sandgren per.sandgren@geol.lu.se Lärare från geologiska institutionen: PS = Per Sandgren, professor BS = Britta Smångs, bibliotekarie, geobiblioteket CS = Charlotte Sparrenbom, universitetslektor DH = Dan Hammarlund, professor Externa lärare: SA = Stefan Andersson, miljöför

https://www.geologi.lu.se/sites/geologi.lu.se/files/geop04_schema_2016-03-29.pdf - 2026-05-30

TIDPLAN-20251113

Blad1 Senast datum Kl Datum t o m System Period Check Checklista inst/fak Information central hantering Länk 11/11/25 Raindance 10 ⃝ Registrera/komplettera intrastatuppgifter. Åtgärda alla poster som har status Ej komplett. Guide 11/25/25 Raindance 11 Bokföringsdag för Statsbudgetanslag – kommer med i saldolistor tidigare 11/25/25 Raindance 11 Bokföringsdag för Primulatransaktioner, kommer med i s

https://www.ekonomiwebben.lu.se/sites/ekonomiwebben.lu.se/files/2025-11/TIDPLAN-20251113.xlsx - 2026-05-30

Schema mv15 ht17 v.2

MILJÖVETENSKAP Preliminärt schema 170609 Kurs: MVEN015, Klimatförändringen, vetenskap och samhälle Kursansvarig: Niklas Vareman Lärare: Giuliana Zanchi, Maj-Lena Linderson, Johannes Stripple, Niklas Vareman, Johanna Alkan-Olsson, Dan Hammarlund, David Harnesk Lokaler: Retina (D227) i Biologihuset, Sölvegatan 35, se karta Se karta http://www.biologi.lu.se/sites/biologi.lu.se/files/biologiv2a4.pdf L

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mv15_ht17_v.2.pdf - 2026-05-30

Schema mv15 ht17 v.1

MILJÖVETENSKAP Preliminärt schema 170609 Kurs: MVEN015, Klimatförändringen, vetenskap och samhälle Kursansvarig: Niklas Vareman Lärare: Giuliana Zanchi, Maj-Lena Linderson, Johannes Stripple, Niklas Vareman, Johanna Alkan-Olsson, Dan Hammarlund, David Harnesk Lokaler: Retina (D227) i Biologihuset, Sölvegatan 35, se karta Se karta http://www.biologi.lu.se/sites/biologi.lu.se/files/biologiv2a4.pdf L

https://www.cec.lu.se/sv/sites/cec.lu.se.sv/files/schema_mv15_ht17_v.1.pdf - 2026-05-30

Monte Carlo simulations of a clay inspired model suspension: the role of rim charge

We present a theoretical investigation of a model clay dispersion in 1-1 salt solutions by varying the particle volume fraction and ionic strength as well as the charge distribution on the clay platelets. The platelets are modeled as discs with charged sites distributed on a hexagonal lattice. The edge sites can be positively charged while the remaining sites are negative giving rise to a strong c