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The prognostic impact of t(12;21)(p13;q22) [ETV6/RUNX1 fusion] in paediatric acute lymphoblastic leukaemia (ALL) has been extensively debated, particularly with regard to the frequency of late relapses and appropriate treatment regimens. We have retrospectively collected 679 ALLs with known ETV6/RUNX1 status, as ascertained by fluorescence in situ hybridization or reverse-transcription polymerase

DNA copy number aberrations (CNAs) are a hallmark of cancer genomes. However, little is known about how such changes affect global gene expression. We develop a modeling framework, EPoC (Endogenous Perturbation analysis of Cancer), to (1) detect disease-driving CNAs and their effect on target mRNA expression, and to (2) stratify cancer patients into long-and short-term survivors. Our method constr

The Italian Sarcoma Group and the Scandinavian Sarcoma Group designed a joint study to improve the prognosis for patients with Ewing's family tumors and synchronous metastatic disease limited to the lungs, or the pleura, or a single bone. The study was opened in 1999 and closed to the enrollment in 2008. The program consisted of intensive five-drug combination chemotherapy, surgery and/or radiothe

27-hydroxycholesterol (27HC), synthesized from cholesterol by the enzyme CYP27A1, differentially impacts estrogen receptor positive (ER+) breast cancer (BC) cell growth depending on estrogen levels. This study examined the association between CYP27A1 expression and prognosis in a cohort of 193 premenopausal patients with lymph node-negative primary BC with limited exposure to adjuvant systemic can

In bottom-up mass spectrometry (MS)-based proteomics, peptide isotopic and chromatographic traces (features) are frequently used for label-free quantification in data-dependent acquisition MS but can also be used for the improved identification of chimeric spectra or sample complexity characterization. Feature detection is difficult because of the high complexity of MS proteomics data from biologi

Catalytic metal sites in enzymes frequently have second-sphere carboxylate groups that neutralize the charge of the site and share protons with first-sphere ligands. This gives rise to an ambiguity concerning the position of this proton, which has turned out to be hard to settle with experimental, as well as theoretical, methods. We study three such proton-transfer reactions in two proteins and sh

Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study Longitudinal Metabolome-Wide Signals Prior to the Appearance of a First Islet Autoantibody in Children Participating in the TEDDY Study Qian Li,1 Hemang Parikh,1 Martha D. Butterworth,1 Åke Lernmark,2 William Hagopian,3 Marian Rewers,4 Jin-Xiong She,5 Jorma Toppar

https://www.teddy.lu.se/sites/teddy.lu.se/files/117_mp224_li_et_al._metabolomics_diabetes.pdf - 2026-07-23

BACKGROUND: The administration of endocrine therapy for 5 years substantially reduces recurrence rates during and after treatment in women with early-stage, estrogen-receptor (ER)-positive breast cancer. Extending such therapy beyond 5 years offers further protection but has additional side effects. Obtaining data on the absolute risk of subsequent distant recurrence if therapy stops at 5 years co

Introduction. Perioperative chemotherapy is the standard treatment for patients with locally advanced resectable gastric cancer. The prognostic relevance of MSI status in patients undergoing neoadjuvant chemotherapy remains unclear. Aim. To study the prognostic significance of MSI in gastric cancer patients undergoing perioperative CT. Materials and methods. The study included 173 patients with lo

2024 VT_LP2 FMSF50 CEQ-kursutvärdering ver 9.0 (2021-01-23) LTH Arbetsrapport CEQ, FMSF50 Basfakta Kursnamn Matematisk statistik, allmän kurs Kurskod FMSF50 Högskolepoäng 7.5 hp Läsår 202324 Kursen slutade i läsperiod VT_LP2 Program samtliga Antal registrerade på kursen 169 Antal enkätsvar/svarsfrekvens 33 / 20 % Antal män som svarat 19 Antal kvinnor som svarat 13 Arbetstid enligt läro- och timpla

https://www.maths.lu.se/fileadmin/maths/utbildning_education/Kursutv_VT24/FMSF50_2024_VT_LP2_arbetsrapport.pdf - 2026-07-20

Vill du läsa juridik? Läs mer om våra utbildningsprogram och kurser Upptäck våra forskningsmiljöer Läs mer om forskningen vid fakulteten Jobba hos oss Här hittar du ledigförklarade anställningar och länk till rekryteringssystemet. Sommaröppettider Särskilda öppettider gäller juni-augusti. Författningskunskap Här hittar du information om kursen i författningskunskap som vi ger på uppdrag av Socials

https://www.jur.lu.se/start - 2026-07-21

Fredrik van Kesbeeck AnderssonFörsäkringsfuskTillvägagångssätt, straffansvar och försäkringsutredningDatum för disputation: fredagen den 16 december 2011Fakultetsopponent: professor Jussi Tapani, Åbo universitet, FinlandÄmne: straffrättAbstractAvhandlingen innehåller tre delar som var och en belyser en aspekt av företeelsen försäkringsfusk. De tre delarna kan ses som självständiga framställningar

https://www.jur.lu.se/forskning/disputationer/disputationer-2011 - 2026-07-21

https://www.thm.lu.se/redovisningar-och-examensproduktioner/hanna-westling - 2026-07-21

Ny Ansats för Jämlikhet i Scenkonsten (NAJS) var ett projekt för jämlik scenkonst som pågick från januari 2021 till juni 2022. Målet för projektet var att Teaterhögskolan skulle berikas med arbetssätt där en mångfald av perspektiv, bakgrunder, kroppar och berättelser får ta plats och bidra till att mer relevant scenkonst skapas på skolan och i framtiden.  Projektorganisationen bestod av projektled

https://www.thm.lu.se/om-oss/jamlikhetsnamnd/najs-diversity-works - 2026-07-21

https://www.covid19app.lu.se/kartor/kartor/stockholm/vecka-22/stockholm-0 - 2026-07-21